Method and device for controlling drug pharmacokinetics
First Claim
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1. A method for delivering a therapeutic substance to a subject comprising delivering the substance within or beneath the skin at least into the intradermal space to access at least two compartments, which compartments afford the substance different pharmacokinetics, which enhance the effectiveness of the substance in terms of a resultant composite pharmacokinetics compared to delivery to a single compartment.
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Abstract
Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling.
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27 Claims
- 1. A method for delivering a therapeutic substance to a subject comprising delivering the substance within or beneath the skin at least into the intradermal space to access at least two compartments, which compartments afford the substance different pharmacokinetics, which enhance the effectiveness of the substance in terms of a resultant composite pharmacokinetics compared to delivery to a single compartment.
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