Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS

• US 20040023972A1
• Filed: 04/11/2003
• Published: 02/05/2004
• Est. Priority Date: 10/13/2000
• Status: Abandoned Application

• Current Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Original Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Inventors: Sundermann, Bernd, Hennies, Hagen-Heinrich, Maul, Corinna, Schneider, Johannes
• Application Number:
  US10/411,402
• Publication Number:
  US 20040023972A1
• Time in Patent Office: Days
• US Class Current: 514/249
• CPC Class Codes: A61K 31/4427 containing further heterocyclic ring systems
• CPC Class Codes: A61K 31/4985 Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A pharmaceutical composition for the treatment of pain, migraine, multiple sclerosis, Parkinson'"'"'s disease, Alzheimer'"'"'s disease, Huntington'"'"'s disease, cerebral ischaemia, diabetes, meningitis, or arteriosclerosis, or a method for healing wounds, the method comprising administering to a patient in need thereof an effective amount of a pharmaceutical composition comprising a compound of formula I

Also disclosed are methods of preparing the compounds of formula I, and treatment methods using the pharmaceutical compositions.

Claims

1. A pharmaceutical composition for treating inflammatory pain or migraine, comprising an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient,

2. A phamarceutical according to claim 1, wherein in formula I

R¹ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, n-hexyl, n-octyl, 1,1,3,3-tetramethylbutyl;

CH₂-aryl, which is unsubstituted or mono- or poly-substituted;

CH₂CO₂—

C_1-6-alkyl, wherein the alkyl is straight-chained or branched;

CH₂PO(O—

C_1-6-alkyl)₂, wherein the alkyl is straight-chained or branched;

CH₂SiR²R¹³R¹⁴, CH₂CH₂-morpholin-4-yl;

(CH₂)_n—

NC, wherein n=2, 3, 4, 5 or 6;

C_3-8-cycloalkyl, wherein the cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, wherein the phenyl is unsubstituted or mono- or poly-substituted,

R² represents H or C(═

O)—

C_1-4-alkyl,

R³ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, cyclopropyl, cyclopentyl or cyclohexyl, which are unsubstituted or mono- or poly-substituted;

phenyl, which is unsubstituted or mono- or poly-substituted;

1-naphthyl or 2-naphthyl, wherein the naphthyl is unsubstituted or mono- or poly-substituted;

9-phenanthrenyl, pyrrol-2-yl, pyrrol-3-yl, pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, wherein the pyrrolyl or pyridinyl are unsubstituted or mono- or poly-substituted;

furan-2-yl or furan-3-yl, wherein the furanyl is unsubstituted or mono- or poly-substituted;

thien-2-yl or thien-3-yl, wherein the thienyl is unsubstituted or mono- or poly-substituted;

imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, wherein the imidazolyl is unsubstituted or mono- or poly-substituted;

thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, wherein the thiazolyl is unsubstituted or mono- or poly-substituted;

oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, wherein the oxazolyl is unsubstituted or mono- or poly-substituted;

isooxazol-3-yl, isooxazol-4-yl, isooxazol-5-yl, wherein the isooxazolyl is unsubstituted or mono- or poly-substituted;

indol-2-yl, benzofuran-2-yl or benzofuran-3-yl,

R⁴, R⁵, R⁶ and R⁷ each independently of the others represents H, methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, CF₃, F, Cl, Br, I, CO₂H, CO₂-methyl, CO₂-ethyl, C(═

O)CH₃ or NO₂, or R⁶ and R⁷ form the hydrocarbon bridge —

CH═

CH—

CH═

CH—

,

R⁸ represents C(═

O)CH₃ and

R¹², R¹³ and R¹⁴ each independently of the others represents C_1-6-alkyl, which is straight-chained or branched and is unsubstituted or mono- or poly-substituted;

C_3-8-cycloalkyl or CH₂—

C_3-8-cycloalkyl, wherein cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, wherein phenyl is unsubstituted or mono- or poly-substituted.

3. A pharmaceutical composition according to claim 2, wherein in formula I

R¹ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, n-hexyl, n-octyl, 1,1,3,3-tetramethylbutyl;

CH₂-aryl, wherein the aryl is unsubstituted or mono- or poly-substituted;

CH₂CO₂—

C_1-6-alkyl, wherein the alkyl is straight-chained or branched;

CH₂PO(O—

C_1-6-alkyl)₂, wherein the alkyl is straight-chained or branched, CH₂SiR²R¹³R⁴, CH₂CH₂-morpholin-4-yl;

(CH₂)_n—

NC, wherein n=2, 3, 4, 5 or 6;

C_3-8-cycloalkyl, wherein the cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, which is unsubstituted or mono- or poly-substituted,

R² represents H or C(═

O)—

C_1-4-alkyl,

R³ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, cyclopropyl, cyclopentyl or cyclohexyl, which, independently of one another, are unsubstituted or mono- or poly-substituted;

phenyl, which is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy and dimethylamino;

1-naphthyl or 2-naphthyl, wherein the naphthyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy and dimethylamino;

9-phenanthrenyl, pyrrol-2-yl;

pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, wherein the pyridinyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy, dimethylamino, carboxy, carboxymethyl, carboxyethyl, hydroxymethyl, chlorophenyl, nitrophenyl, [1,3]-dioxolan and methylsulfanyl;

furan-2-yl or furan-3-yl, wherein the furanyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy, dimethylamino, carboxy, carboxymethyl, carboxyethyl, hydroxymethyl, chlorophenyl, nitrophenyl, [1,3]-dioxolan and methylsulfanyl;

thien-2-yl or thien-3-yl, wherein the thienyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy, dimethylamino, carboxy, carboxymethyl, carboxyethyl, hydroxymethyl, chlorophenyl, nitrophenyl, [1,3]-dioxolan and methylsulfanyl;

indol-2-yl, benzofuran-2-yl or benzofuran-3-yl,

R⁴, R⁵, R⁶ and R⁷ each independently of the others represents H, methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, CF₃, F, Cl, Br, I, CO₂H, CO₂-methyl, CO₂-ethyl, C(═

O)CH₃ or NO₂, or

R⁶ and R⁷ form the hydrocarbon bridge —

CH═

CH—

CH═

CH—

,

R⁸ represents C(═

O)CH₃ and

R¹², R¹³ and R¹⁴ each independently of the others represents C_1-6-alkyl, which is straight-chained or branched, and unsubstituted or mono- or poly-substituted;

C_3-8-cycloalkyl or CH₂—

C_3-8-cycloalkyl, wherein the cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, wherein the phenyl is unsubstituted or mono- or poly-substituted.

4. A pharmaceutical composition according to claim 3, wherein in formula I

R¹ represents methyl, n-butyl, 1,1,3,3-tetramethylbutyl, benzyl, 2-chlorobenzyl, 2-methoxybenzyl, CH₂CO₂CH₃, (CH₂)₆—

NC, cyclopentyl, cyclohexyl, phenyl, 2,6-dimethylphenyl, 3-chlorophenyl or 3-chloro-4-fluorophenyl,

R² represents H or C(═

O)CH₃,

R³ represents methyl, tert-butyl, cyclohexyl, phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-hydroxyphenyl, 2-methoxyphenyl, 3-hydroxyphenyl, 3-methoxyphenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-bromophenyl, 3-bromophenyl, 4-bromophenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl, 3-(4-chlorophenoxy)-phenyl, 2,4-dimethylphenyl, 2,3-dimethoxyphenyl, 3,4-dimethoxyphenyl, 3-methoxy-4-acetoxyphenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2-chloro-4-fluorophenyl, 2-chloro-6-fluorophenyl, 4-bromo-2-fluorophenyl, 3,4,5-trimethoxyphenyl, 1-naphthyl, 2-ethoxy-naphth-1-yl, 4-dimethylamino-napth-1-yl, 9-phenanthrenyl, pyrrol-2-yl, N-methylpyrrol-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, furan-2-yl, furan-3-yl, 5-methyl-furan-2-yl, 4,5-dimethyl-furan-2-yl, 5-hydroxymethyl-furan-2-yl, 5-acetoxymethyl-furan-2-yl, 5-carboxy-furan-2-yl, 5-[1,3]-dioxolan-furan-2-yl, 3-bromo-furan-2-yl, 5-bromo-furan-2-yl, 5-nitro-furan-2-yl, 5-(2-nitrophenyl)-furan-2-yl, 5-(2-chlorophenyl)-furan-2-yl, 5-(3-chlorophenyl)-furan-2-yl, 5-(3-chlorophenyl)-furan-3-yl, 5-(4-chlorophenyl)-furan-2-yl, benzo[b]furan-2-yl, thien-2-yl, thien-3-yl, 5-methyl-thien-2-yl, 5-carboxy-thien-2-yl, 3-bromo-thien-2-yl, 5-chloro-thien-2-yl or 5-methylsulfanyl-thien-2-yl,

R⁴ represents H, CH₃, Cl, Br or CO₂H,

R⁵ represents H, CH₃, C₂H₅ or Cl,

R⁶ represents H, CH₃, Cl, Br or NO₂,

R⁷ represents H, CH₃ or n-C₃H₇ and

R⁸ represents C(═

O)CH₃.

5. A pharmaceutical composition according to claim 4, wherein in formula I R⁴ and R⁶ represent H, R⁵ represents H, CH₃ or C₂H₅ and R⁷ represents H or CH₃.

6. A pharmaceutical composition according to claim 5, wherein the compound is selected from the group consisting of:

tert-butyl-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

{6-[5,7-dimethyl-2-(1H-pyrrol-2-yl)-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

tert-butyl-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-amine,

[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1, 1,3,3-tetramethyl-butyl)-amine,

cyclohexyl-(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

(1,1,3,3-tetramethyl-butyl)-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(7-methyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

cyclohexyl-[7-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine,

tert-butyl-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

cyclohexyl-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

(2,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-acetic acid methyl ester,

methylidyne-[6-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

3-(3-tert-butylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

cyclohexyl-[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

tert-butyl-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

3-(3-tert-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

tert-butyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

butyl-(2-cyclohexyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

3-[5,7-dimethyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-phenol,

(2,6-dimethyl-phenyl)-(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-amine,

tert-butyl-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

cyclohexyl-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

[5,7-dimethyl-2-(1H-pyrrol-2-yl)-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

butyl-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

[2-(2,3-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(3-bromo-thiophen-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

[6-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(2,3-dichloro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethylphenyl)-amine,

[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

butyl-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-amine,

methylidyne-[6-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

tert-butyl-[5,7-dimethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

acetic acid 5-(3-cyclohexylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-yl methyl ester,

[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

3-(3-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(2,6-dimethylphenyl)-amine,

acetic acid 5-(3-cyclohexylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-yl methyl ester,

[6-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

butyl-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

{6-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

{5-[5,7-dimethyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl}-methanol,

(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[5-(3-tert-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-yl]-methanol,

tert-butyl-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

5-(3-tert-butylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-carboxylic acid,

tert-butyl-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2,3-dichlorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

3-(3-butylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

butyl-[2-(2,3-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

{6-[5,7-dimethyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

tert-butyl-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2,3-dichlorophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

{2-[5-(2-chlorophenyl)-furan-2-yl]-7-methyl-imidazo[1,2-a]pyridin-3-yl}-(1,1,3,3-tetramethyl-butyl)-amine,

5-[7-methyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-furan-2-carboxylic acid,

cyclohexyl-[2-(2-methoxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

3-[7-methyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-phenol,

[2-(2,3-dichlorophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(2,4-dichlorophenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(5-bromofuran-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

5-(3-cyclohexylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-carboxylic acid,

[6-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

[2-(2,4-dichlorophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(2,6-dimethylphenyl)-amine,

5-(3-cyclohexylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-carboxylic acid,

{6-[2-(2-bromophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

tert-butyl-(2-cyclohexyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

tert-butyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

[2-(2,3-dichlorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethylphenyl)-amine,

methylidyne-[6-(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

{2-[5-(3-chlorophenyl)-furan-2-yl]-7-methyl-imidazo[1,2-a]pyridin-3-yl}-(1,1,3,3-tetramethyl-butyl)-amine,

cyclohexyl-[7-methyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

[2-(2-bromophenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-cyclohexyl-amine,

[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

{5-[7-methyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl}-methanol,

(6-{2-[5-(2-chlorophenyl)-furan-2-yl]-5-methyl-imidazo[1,2-a]pyridin-3-ylamino}-hexyl)-methylidyne-ammonium,

cyclohexyl-[5,7-dimethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

cyclohexyl-[2-(4,5-dimethyl-furan-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

[6-(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

methylidyne-[6-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

{6-[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

5-(3-tert-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-thiophene-2-carboxylic acid,

cyclohexyl-(8-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2,3-dichloro-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

5-(3-butylamino-imidazo[1,2-a]pyrazin-2-yl)-thiophene-2-carboxylic acid,

cyclohexyl-(5,7-dimethyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-benzofuran-2-yl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

{6-[2-(2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

[2-(2,3-dimethoxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

methylidyne-[6-(7-methyl-2-phenanthren-9-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

5-(3-tert-butylamino-imidazo[1,2-a]pyrazin-2-yl)-thiophene-2-carboxylic acid,

tert-butyl-(8-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-furan-2-yl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

methylidyne-[6-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

tert-butyl-(2-cyclohexyl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(6-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

tert-butyl-(6-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyrimidin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

5-(3-tert-butylamino-6-methyl-imidazo[1,2-a]pyridin-2-yl)-thiophene-2-carboxylic acid,

[6-(5,7-dimethyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

3-[3-(2,6-dimethyl-phenylamino)-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl]-phenol,

(2,6-dimethyl-phenyl)-(8-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-amine,

{6-[2-(3-hydroxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

{5-[3-(2,6-dimethyl-phenylamino)-7-methyl-imidazo[1,2-a]pyrimidin-2-yl]-furan-2-yl}-methanol,

(8-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(2,4-dichlorophenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethylphenyl)-amine,

butyl-[2-(2,4-dichloro-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

butyl-[2-(4-dimethylamino-naphthalen-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-amine,

{6-[2-(2-bromo-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

butyl-[2-(2-methoxy-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

(2-cyclohexyl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

cyclohexyl-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-acetic acid methyl ester,

N-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-tert-butyl-N-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

N-(1,1,3,3-tetramethyl-butyl)-N-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-(7-methyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

5-[3-(acetyl-tert-butyl-amino)-imidazo[1,2-a]pyrazin-2-yl]-thiophene-2-carboxylic acid,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-5,7-dimethyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

N-[2-(5-hydroxymethyl-furan-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(3-bromo-thiophen-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-tert-butyl-N-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

acetic acid 5-[3-(acetyl-cyclohexyl-amino)-5,7-dimethyl-imidazo[1,2-a]-pyridin-2-yl]-furan-2-yl methyl ester,

{6-[acetyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-[2-(2,3-dichloro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-[2-(3-bromo-thiophen-2-yl)-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

N-(5,7-dimethyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-[7-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-(6,8-dibromo-2-furan-2-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl).—

N-(1,1,3,3-tetramethyl-butyl)-acetamide,

acetic acid 5-[3-(acetyl-cyclohexyl-amino)-7-methyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl methyl ester,

N-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(2,3-dichloro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-cyclohexyl-N-[5,7-dimethyl-2-(5-methyl-furan-2-yl)-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-butyl-N-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-[5,7-dimethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

[acetyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amino]-acetic acid methyl ester,

N-cyclohexyl-N-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-imidazo[1,2-a]pyridin-2-yl}-thiophene-2-carboxylic acid,

N-[2-(2,4-dichloro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-[7-methyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-(2-tert-butyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethylphenyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(3-hydroxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

5-[3-(acetyl-tert-butyl-amino)-5-methyl-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

N-(2,6-dimethyl-phenyl)-N-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-7-methyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

N-cyclohexyl-N-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethyl-phenyl)-acetamide,

N-tert-butyl-N-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-[2-(2,3-dichloro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-{2-[3-(4-chloro-phenoxy)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-N-(2,6-dimethyl-phenyl)-acetamide,

N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

5-[3-(acetyl-cyclohexyl-amino)-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-carboxylic acid,

N-tert-butyl-N-[7-methyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(5-methyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

5-[3-(acetyl-tert-butyl-amino)-7-methyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-carboxylic acid,

N-[2-(4,5-dimethyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-imidazo[1,2-a]pyrazin-2-yl}-thiophene-2-carboxylic acid,

N-butyl-N-(2-o-tolyl-imidazo[1,2-a]pyrimidin-3-yl)acetamide,

N-[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-tert-butyl-N-(7-methyl-2-phenanthren-9-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-[2-(2-methoxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(3-hydroxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-(2-tert-butyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethylphenyl)-acetamide,

acetic acid 4-{3-[acetyl-(2,6-dimethyl-phenyl)-amino]-6-bromo-8-methyl-imidazo[1,2-a]pyridin-2-yl}-2-methoxy-phenyl ester,

N-tert-butyl-N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

[6-(acetyl-{7-methyl-2-[5-(2-nitro-phenyl)-furan-2-yl]-imidazo[1,2-a]pyridin-3-yl}-amino)-hexyl]-methylidyne-ammonium,

N-(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

5-[3-(acetyl-tert-butyl-amino)-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

N-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-tert-butyl-N-[2-(5-methyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-tert-butyl-N-[2-(5-methylsulfanyl-thiophen-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-[2-(4,5-dimethyl-furan-2-yl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-butyl-N-[2-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-[2-(3-bromo-thiophen-2-yl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

5-{3-[acetyl-(2,6-dimethyl-phenyl)-amino]-6-methyl-imidazo[1,2-a]pyridin-2-yl}-thiophene-2-carboxylic acid,

N-butyl-N-[2-(2,3-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-tert-butyl-N-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-(2-furan-2-yl-5-propyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

5-[3-(acetyl-cyclohexyl-amino)-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-8-methyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

3-(acetyl-butyl-amino)-2-pyridin-2-yl-imidazo[1,2-a]pyridine-8-carboxylic acid,

{6-[acetyl-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-tert-butyl-N-[2-(5-methylsulfanyl-thiophen-2-yl)-imidazo[1,2-a]pyrazin-3-yl]-acetamide,

5-[3-(acetyl-cyclohexyl-amino)-5-methyl-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

N-[2-(5-methylsulfanyl-thiophen-2-yl)-imidazo[1,2-a]pyrazin-3-y]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(2,3-dichloro-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-butyl-N-[2-(2-methoxy-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

(6-{acetyl-[2-(2-methoxy-phenyl)-6-nitro-imidazo[1,2-a]pyridin-3-yl]-amino}-hexyl)-methylidyne-ammonium,

N-(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethylphenyl)-acetamide,

(6-{acetyl-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-amino}-hexyl)-methylidyne-ammonium,

{6-[acetyl-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

acetic acid 5-{3-[acetyl-(2,6-dimethyl-phenyl)-amino]-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl}-furan-2-yl methyl ester,

{acetyl-[2-(3-hydroxy-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-amino}-acetic acid methyl ester,

N-tert-butyl-N-[2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-butyl-N-[2-(2-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethylphenyl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-7-methyl-imidazo[1,2-a]-pyrimidin-2-yl}-furan-2-carboxylic acid,

acetic acid 5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-imidazo[1,2-a]-pyrimidin-2-yl}-furan-2-yl methyl ester,

N-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

acetic acid 4-[3-(acetyl-cyclohexyl-amino)-5-amino-7-chloro-imidazo[1,2-a]-pyrimidin-2-yl]-2-methoxy-phenyl ester,

acetic acid 4-[3-(acetyl-cyclohexyl-amino)-5,7-dimethyl-imidazo[1,2-a]-pyrimidin-2-yl]-2-methoxy-phenyl ester,

N-[6-bromo-2-(2-chloro-6-fluoro-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

N-[2-(2-chloro-6-fluoro-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

N-butyl-N-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-[2-(5-chloro-thiophen-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

[acetyl-(2-cyclohexyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amino]-acetic acid methyl ester,

N-tert-butyl-N-[2-(2-chloro-6-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-(5,7-dimethyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

acetic acid 5-[3-(acetyl-cyclohexyl-amino)-5-methyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl methyl ester,

N-(2,6-dimethyl-phenyl)-N-[6-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-tert-butyl-N-(5-propyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-[2-(5-methyl-thiophen-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-2-furan-2-yl-imidazo[1,2-a]-pyridine-8-carboxylic acid,

N-tert-butyl-N-[2-(4,5-dimethyl-furan-2-yl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-{2-[3-(4-chloro-phenoxy)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-N-cyclohexyl-acetamide,

acetic acid 4-[3-(acetyl-cyclohexyl-amino)-imidazo[1,2-a]pyrimidin-2-yl]-2-methoxy-phenyl ester,

N-[2-(5-bromo-furan-2-yl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(3-hydroxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-cyclohexyl-N-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-[2-(2,4-dichloro-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-[2-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

[acetyl-(2-o-tolyl-imidazo[1,2-a]pyrazin-3-yl)-amino]-acetic acid methyl ester,

N-tert-butyl-N-(6,8-dichloro-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(5-propyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

{6-[acetyl-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-butyl-N-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

(6-{acetyl-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amino}-hexyl)-methylidyne-ammonium,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-6-methyl-imidazo[1,2-a]pyridin-2-yl}-furan-2-carboxylic acid,

N-butyl-N-[2-(3,4,5-trimethoxy-phenyl)-imidazo[1,2-a]pyrazin-3-yl]acetamide,

N-butyl-N-[2-(3-hydroxy-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

[acetyl-(2-o-tolyl-imidazo[1,2-a]pyrimidin-3-yl)-amino]-acetic acid methyl ester,

N-(2-benzofuran-2-yl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-butyl-N-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyrimidin-3-yl)-acetamide,

N-tert-butyl-N-(6,8-dibromo-2-methyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

{6-[acetyl-(5,7-dimethyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-tert-butyl-N-[2-(2-ethoxy-naphthalen-1-yl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-tert-butyl-N-[2-(2-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

cyclohexyl-[7-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine hydrochloride,

tert-butyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

tert-butyl-(7-methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

cyclohexyl-(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

tert-butyl-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

[2-(2-fluorophenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine hydrochloride,

cyclohexyl-(7-methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyrimidin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

tert-butyl-[2-(4-nitro-phenyl)-imidazo[1,2-a]pyrazin-3-yl]-amine hydrochloride,

N-{2-[3-(4-chlorophenoxy)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-N-cyclohexyl-acetamide hydrochloride,

N-cyclohexyl-N-(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide hydrochloride,

N-(2,6-dimethyl-phenyl)-N-[2-(2,4-dimethyl-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide hydrochloride,

1-acetyl-3-(acetyl-cyclohexyl-amino)-7-methyl-2-o-tolyl-imidazo[1,2-a]-pyridin-1-ium) chloride hydrochloride,

cyclohexyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

cyclopentyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

[2-(4-bromo-2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]cyclopentyl-amine hydrochloride,

cyclopentyl-{5,7-dimethyl-2-[5-(2-nitro-phenyl)-furan-2-yl]-imidazo[1,2-a]-pyridin-3-yl}-amine hydrochloride,

{2-[5-(4-chlorophenyl)-furan-2-yl]-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl}-cyclopentyl-amine hydrochloride,

cyclopentyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

benzyl-(7-methyl-2-thiophen-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

cyclohexyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-3-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

(5,7-dimethyl-2-thiophen-3-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine hydrochloride,

[7-ethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-(2-methoxybenzyl)-amine,

(2-chlorobenzyl)-[7-ethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

[7-ethyl-2-(5-methyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-(2-methoxybenzyl)-amine,

(2-chlorobenzyl)-(7-ethyl-2-furan-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(3-chloro-4-fluorophenyl)-[7-ethyl-2-(5-methyl-furan-2-yl)-imidazo[1,2-a]-pyridin-3-yl]-amine,

(2-benzofuran-2-yl-7-ethyl-imidazo[1,2-a]pyridin-3-yl)-(3-chloro-4-fluorophenyl)-amine,

(2-benzofuran-2-yl-7-ethyl-imidazo[1,2-a]pyridin-3-yl)-(3-chlorophenyl)-amine,

(3-chloro-4-fluorophenyl)-{2-[5-(3-chloro-phenyl)-furan-2-yl]-7-ethyl-imidazo[1,2-a]pyridin-3-yl}-amine,

(3-chloro-4-fluorophenyl)-{2-[5-(2-chlorophenyl)-furan-2-yl]-7-ethyl-imidazo[1,2-a]pyridin-3-yl}-amine,

(3-chloro-4-fluorophenyl)-[2-(4,5-dimethyl-furan-2-yl)-7-ethyl-imidazo[1,2-a]pyridin-3-yl]-amine.

13. A method for treating inflammatory pain, or migraine, or both, comprising administering an effective amount of a pharmaceutical composition according to claim 1 to a patient in need thereof.

14. A method according to claim 13, wherein the patient is human.

15. A method for treating inflammatory pain, or migraine, or both, comprising administering an effective amount of a pharmaceutical composition according to claim 6 to a patient in need thereof.

17. A method according to claim 15, wherein the patient is human.

7. A pharmaceutical composition for treating one or more diseases selected from the group consisting of multiple sclerosis, Parkinson'"'"'s disease, Alzheimer'"'"'s disease, Huntington'"'"'s disease, cerebral ischaemia, diabetes, meningitis, and arteriosclerosis, or for healing wounds, the pharmaceutical composition comprising an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient,

8. A phamarceutical according to claim 7, wherein in formula I

R¹ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, n-hexyl, n-octyl, 1, 1,3,3-tetramethylbutyl;

CH₂-aryl, which is unsubstituted or mono- or poly-substituted;

CH₂CO₂—

C_1-6-alkyl, wherein the alkyl is straight-chained or branched;

CH₂PO(O—

C_1-6-alkyl)₂, wherein the alkyl is straight-chained or branched;

CH₂SiR²R¹³R¹⁴, CH₂CH₂-morpholin-4-yl;

(CH₂)_n—

NC, wherein n=2, 3, 4, 5 or 6;

C_3-8-cycloalkyl, wherein the cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, wherein the phenyl is unsubstituted or mono- or poly-substituted,

R² represents H or C(═

O)—

C_1-4-alkyl,

R³ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, cyclopropyl, cyclopentyl or cyclohexyl, which are unsubstituted or mono- or poly-substituted;

phenyl, which is unsubstituted or mono- or poly-substituted;

1-naphthyl or 2-naphthyl, wherein the naphthyl is unsubstituted or mono- or poly-substituted;

9-phenanthrenyl, pyrrol-2-yl, pyrrol-3-yl, pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, wherein the pyrrolyl or pyridinyl are unsubstituted or mono- or poly-substituted;

furan-2-yl or furan-3-yl, wherein the furanyl is unsubstituted or mono- or poly-substituted;

thien-2-yl or thien-3-yl, wherein the thienyl is unsubstituted or mono- or poly-substituted;

imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, wherein the imidazolyl is unsubstituted or mono- or poly-substituted;

thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, wherein the thiazolyl is unsubstituted or mono- or poly-substituted;

oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, wherein the oxazolyl is unsubstituted or mono- or poly-substituted;

isooxazol-3-yl, isooxazol-4-yl, isooxazol-5-yl, wherein the isooxazolyl is unsubstituted or mono- or poly-substituted;

indol-2-yl, benzofuran-2-yl or benzofuran-3-yl,

R⁴, R⁵, R⁶ and R⁷ each independently of the others represents H, methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, CF₃, F, Cl, Br, I, CO₂H, CO₂-methyl, CO₂-ethyl, C(═

O)CH₃ or NO₂, or R⁶ and R⁷ form the hydrocarbon bridge —

CH═

CH—

CH═

CH—

,

R⁸ represents C(═

O)CH₃ and

R¹², R¹³ and R¹⁴ each independently of the others represents C_1-6-alkyl, which is straight-chained or branched and is unsubstituted or mono- or poly-substituted;

C_3-8-cycloalkyl or CH₂—

C_3-8-cycloalkyl, wherein cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, wherein phenyl is unsubstituted or mono- or poly-substituted.

9. A pharmaceutical composition according to claim 8, wherein in formula I

R¹ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, n-hexyl, n-octyl, 1,1,3,3-tetramethylbutyl;

CH₂-aryl, wherein the aryl is unsubstituted or mono- or poly-substituted;

CH₂CO₂—

C_1-6-alkyl, wherein the alkyl is straight-chained or branched;

CH₂PO(O—

C_1-6-alkyl)₂, wherein the alkyl is straight-chained or branched, CH₂SiR¹²R³R¹⁴, CH₂CH₂-morpholin-4-yl;

(CH₂)_n—

NC, wherein n=2, 3, 4, 5 or 6;

C_3-8-cycloalkyl, wherein the cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, which is unsubstituted or mono- or poly-substituted,

R² represents H or C(═

O)—

C_1-4-alkyl,

R³ represents methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, cyclopropyl, cyclopentyl or cyclohexyl, which, independently of one another, are unsubstituted or mono- or poly-substituted;

phenyl, which is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy and dimethylamino;

1-naphthyl or 2-naphthyl, wherein the naphthyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy and dimethylamino;

9-phenanthrenyl, pyrrol-2-yl;

pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, wherein the pyridinyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy, dimethylamino, carboxy, carboxymethyl, carboxyethyl, hydroxymethyl, chlorophenyl, nitrophenyl, [1,3]-dioxolan and methylsulfanyl;

furan-2-yl or furan-3-yl, wherein the furanyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy, dimethylamino, carboxy, carboxymethyl, carboxyethyl, hydroxymethyl, chlorophenyl, nitrophenyl, [1,3]-dioxolan and methylsulfanyl;

thien-2-yl or thien-3-yl, wherein the thienyl is unsubstituted or monosubstituted or poly-substituted by identical or different substituents selected from the group consisting of methyl, ethyl, n-propyl, prop-2-yl, n-butyl, sec-butyl, tert-butyl, isobutyl, CF₃, OH, O-methyl, O-ethyl, F, Cl, Br, I, CN, NO₂, 4-chlorophenoxy, acetoxy, dimethylamino, carboxy, carboxymethyl, carboxyethyl, hydroxymethyl, chlorophenyl, nitrophenyl, [1,3]-dioxolan and methylsulfanyl;

indol-2-yl, benzofuran-2-yl or benzofuran-3-yl,

R⁴, R⁵, R⁶ and R⁷ each independently of the others represents H, methyl, ethyl, n-propyl, 2-propyl, n-butyl, tert-butyl, CF₃, F, Cl, Br, I, CO₂H, CO₂-methyl, CO₂-ethyl, C(═

O)CH₃ or NO₂, or

R⁶ and R⁷ form the hydrocarbon bridge —

CH═

CH—

CH═

CH—

,

R⁸ represents C(═

O)CH₃ and

R¹², R¹³ and R¹⁴ each independently of the others represents C_1-6-alkyl, which is straight-chained or branched, and unsubstituted or mono- or poly-substituted;

C_3-8-cycloalkyl or CH₂—

C_3-8-cycloalkyl, wherein the cycloalkyl is unsubstituted or mono- or poly-substituted;

or phenyl, wherein the phenyl is unsubstituted or mono- or poly-substituted.

10. A pharmaceutical composition according to claim 9, wherein in formula I

R¹ represents methyl, n-butyl, 1,1,3,3-tetramethylbutyl, benzyl, 2-chlorobenzyl, 2-methoxybenzyl, CH₂CO₂CH₃, (CH₂)₆—

NC, cyclopentyl, cyclohexyl, phenyl, 2,6-dimethylphenyl, 3-chlorophenyl or 3-chloro-4-fluorophenyl,

R² represents H or C(═

O)CH₃,

R³ represents methyl, tert-butyl, cyclohexyl, phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-hydroxyphenyl, 2-methoxyphenyl, 3-hydroxyphenyl, 3-methoxyphenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-bromophenyl, 3-bromophenyl, 4-bromophenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl, 3-(4-chlorophenoxy)-phenyl, 2,4-dimethylphenyl, 2,3-dimethoxyphenyl, 3,4-dimethoxyphenyl, 3-methoxy-4-acetoxyphenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 2-chloro-4-fluorophenyl, 2-chloro-6-fluorophenyl, 4-bromo-2-fluorophenyl, 3,4,5-trimethoxyphenyl, 1-naphthyl, 2-ethoxy-naphth-1-yl, 4-dimethylamino-napth-1-yl, 9-phenanthrenyl, pyrrol-2-yl, N-methylpyrrol-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, furan-2-yl, furan-3-yl, 5-methyl-furan-2-yl, 4,5-dimethyl-furan-2-yl, 5-hydroxymethyl-furan-2-yl, 5-acetoxymethyl-furan-2-yl, 5-carboxy-furan-2-yl, 5-[1,3]-dioxolan-furan-2-yl, 3-bromo-furan-2-yl, 5-bromo-furan-2-yl, 5-nitro-furan-2-yl, 5-(2-nitrophenyl)-furan-2-yl, 5-(2-chlorophenyl)-furan-2-yl, 5-(3-chlorophenyl)-furan-2-yl, 5-(3-chlorophenyl)-furan-3-yl, 5-(4-chlorophenyl)-furan-2-yl, benzo[b]furan-2-yl, thien-2-yl, thien-3-yl, 5-methyl-thien-2-yl, 5-carboxy-thien-2-yl, 3-bromo-thien-2-yl, 5-chloro-thien-2-yl or 5-methylsulfanyl-thien-2-yl,

R⁴ represents H, CH₃, Cl, Br or CO₂H,

R⁵ represents H, CH₃, C₂H₅ or Cl,

R⁶ represents H, CH₃, Cl, Br or NO₂,

R⁷ represents H, CH₃ or n-C₃H₇ and

R⁸ represents C(═

O)CH₃.

11. A pharmaceutical composition according to claim 10, wherein in formula I R⁴ and R⁶ represent H, R⁵ represents H, CH₃ or C₂H₅ and R⁷ represents H or CH₃.

12. A pharmaceutical composition according to claim 11, wherein the compound is selected from the group consisting of:

tert-butyl-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

{6-[5,7-dimethyl-2-(1H-pyrrol-2-yl)-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

tert-butyl-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-amine,

[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

cyclohexyl-(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

(1,1,3,3-tetramethyl-butyl)-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(7-methyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

cyclohexyl-[7-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine,

tert-butyl-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

cyclohexyl-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

(2,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-acetic acid methyl ester,

methylidyne-[6-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

3-(3-tert-butylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

cyclohexyl-[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

tert-butyl-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

3-(3-tert-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

tert-butyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

butyl-(2-cyclohexyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

3-[5,7-dimethyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-phenol,

(2,6-dimethyl-phenyl)-(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-amine,

tert-butyl-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

cyclohexyl-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

[5,7-dimethyl-2-(1H-pyrrol-2-yl)-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

butyl-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

[2-(2,3-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(3-bromo-thiophen-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

[6-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(2,3-dichloro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethylphenyl)-amine,

[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

butyl-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-amine,

methylidyne-[6-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

tert-butyl-[5,7-dimethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

acetic acid 5-(3-cyclohexylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-yl methyl ester,

[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

3-(3-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(2,6-dimethylphenyl)-amine,

acetic acid 5-(3-cyclohexylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-yl methyl ester,

[6-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

butyl-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

{6-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

{5-[5,7-dimethyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl}-methanol,

(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[5-(3-tert-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-yl]-methanol,

tert-butyl-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

5-(3-tert-butylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-carboxylic acid,

tert-butyl-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2,3-dichlorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

3-(3-butylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-phenol,

butyl-[2-(2,3-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

{6-[5,7-dimethyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

tert-butyl-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2,3-dichlorophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethyl-phenyl)-amine,

(2,6-dimethyl-phenyl)-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]-pyridin-3-yl]-amine,

{2-[5-(2-chlorophenyl)-furan-2-yl]-7-methyl-imidazo[1,2-a]pyridin-3-yl}-(1,1,3,3-tetramethyl-butyl)-amine,

5-[7-methyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-furan-2-carboxylic acid,

cyclohexyl-[2-(2-methoxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

3-[7-methyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-phenol,

[2-(2,3-dichlorophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(2,4-dichlorophenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(5-bromofuran-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

5-(3-cyclohexylamino-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-carboxylic acid,

[6-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

[2-(2,4-dichlorophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(2,6-dimethylphenyl)-amine,

5-(3-cyclohexylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-furan-2-carboxylic acid,

{6-[2-(2-bromophenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

tert-butyl-(2-cyclohexyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

tert-butyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(5,7-dimethyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

[2-(2,3-dichlorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethylphenyl)-amine,

methylidyne-[6-(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

{2-[5-(3-chlorophenyl)-furan-2-yl]-7-methyl-imidazo[1,2-a]pyridin-3-yl}-(1,1,3,3-tetramethyl-butyl)-amine,

cyclohexyl-[7-methyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

[2-(2-bromophenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-cyclohexyl-amine,

[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

{5-[7-methyl-3-(1,1,3,3-tetramethyl-butylamino)-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl}-methanol,

(6-{2-[5-(2-chlorophenyl)-furan-2-yl]-5-methyl-imidazo[1,2-a]pyridin-3-ylamino}-hexyl)-methylidyne-ammonium,

cyclohexyl-[5,7-dimethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

cyclohexyl-[2-(4,5-dimethyl-furan-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

[6-(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

methylidyne-[6-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

{6-[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

5-(3-tert-butylamino-7-methyl-imidazo[1,2-a]pyridin-2-yl)-thiophene-2-carboxylic acid,

cyclohexyl-(8-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

[2-(2,3-dichloro-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

5-(3-butylamino-imidazo[1,2-a]pyrazin-2-yl)-thiophene-2-carboxylic acid,

cyclohexyl-(5,7-dimethyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-benzofuran-2-yl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

{6-[2-(2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

[2-(2,3-dimethoxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine,

methylidyne-[6-(7-methyl-2-phenanthren-9-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

5-(3-tert-butylamino-imidazo[1,2-a]pyrazin-2-yl)-thiophene-2-carboxylic acid,

tert-butyl-(8-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-furan-2-yl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

methylidyne-[6-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-ammonium,

tert-butyl-(2-cyclohexyl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(6-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

tert-butyl-(6-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyrimidin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

5-(3-tert-butylamino-6-methyl-imidazo[1,2-a]pyridin-2-yl)-thiophene-2-carboxylic acid,

[6-(5,7-dimethyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-ylamino)-hexyl]-methylidyne-ammonium,

3-[3-(2,6-dimethyl-phenylamino)-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl]-phenol,

(2,6-dimethyl-phenyl)-(8-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-amine,

{6-[2-(3-hydroxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

{5-[3-(2,6-dimethyl-phenylamino)-7-methyl-imidazo[1,2-a]pyrimidin-2-yl]-furan-2-yl}-methanol,

(8-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine,

[2-(2,4-dichlorophenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-(2,6-dimethylphenyl)-amine,

butyl-[2-(2,4-dichloro-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

butyl-[2-(4-dimethylamino-naphthalen-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-amine,

{6-[2-(2-bromo-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-ylamino]-hexyl}-methylidyne-ammonium,

butyl-[2-(2-methoxy-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-amine,

(2-cyclohexyl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine,

cyclohexyl-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

cyclohexyl-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine,

(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-ylamino)-acetic acid methyl ester,

N-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-tert-butyl-N-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-(5,7-dimethyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

N-(1,1,3,3-tetramethyl-butyl)-N-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-(7-methyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

5-[3-(acetyl-tert-butyl-amino)-imidazo[1,2-a]pyrazin-2-yl]-thiophene-2-carboxylic acid,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-5,7-dimethyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

N-[2-(5-hydroxymethyl-furan-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(3-bromo-thiophen-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-tert-butyl-N-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

acetic acid 5-[3-(acetyl-cyclohexyl-amino)-5,7-dimethyl-imidazo[1,2-a]-pyridin-2-yl]-furan-2-yl methyl ester,

{6-[acetyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-[2-(2,3-dichloro-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-[2-(3-bromo-thiophen-2-yl)-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

N-(5,7-dimethyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)acetamide,

N-cyclohexyl-N-[7-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-(6,8-dibromo-2-furan-2-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(7-methyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

acetic acid 5-[3-(acetyl-cyclohexyl-amino)-7-methyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl methyl ester,

N-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(2,3-dichloro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-cyclohexyl-N-[5,7-dimethyl-2-(5-methyl-furan-2-yl)-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-butyl-N-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-[5,7-dimethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

[acetyl-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amino]-acetic acid methyl ester,

N-cyclohexyl-N-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-imidazo[1,2-a]pyridin-2-yl}-thiophene-2-carboxylic acid,

N-[2-(2,4-dichloro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-[7-methyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-(2-tert-butyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethylphenyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(3-hydroxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

5-[3-(acetyl-tert-butyl-amino)-5-methyl-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

N-(2,6-dimethyl-phenyl)-N-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-7-methyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

N-cyclohexyl-N-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethyl-phenyl)-acetamide,

N-tert-butyl-N-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-[2-(2,3-dichloro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(2,3-dimethoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-{2-[3-(4-chloro-phenoxy)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-N-(2,6-dimethyl-phenyl)-acetamide,

N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

5-[3-(acetyl-cyclohexyl-amino)-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-carboxylic acid,

N-tert-butyl-N-[7-methyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(5-methyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

5-[3-(acetyl-tert-butyl-amino)-7-methyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-carboxylic acid,

N-[2-(4,5-dimethyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-cyclohexyl-N-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(7-methyl-2-naphthalen-1-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-imidazo[1,2-a]pyrazin-2-yl}-thiophene-2-carboxylic acid,

N-butyl-N-(2-o-tolyl-imidazo[1,2-a]pyrimidin-3-yl)acetamide,

N-[2-(3,4-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-tert-butyl-N-(7-methyl-2-phenanthren-9-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(2-fluoro-phenyl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-[2-(2-methoxy-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(3-hydroxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-(2-tert-butyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethylphenyl)-acetamide,

acetic acid 4-{3-[acetyl-(2,6-dimethyl-phenyl)-amino]-6-bromo-8-methyl-imidazo[1,2-a]pyridin-2-yl}-2-methoxy-phenyl ester,

N-tert-butyl-N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

[6-(acetyl-{7-methyl-2-[5-(2-nitro-phenyl)-furan-2-yl]-imidazo[1,2-a]pyridin-3-yl }-amino)-hexyl]-methylidyne-ammonium,

N-(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2-benzofuran-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

5-[3-(acetyl-tert-butyl-amino)-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

N-(2-cyclohexyl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-tert-butyl-N-[2-(5-methyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-tert-butyl-N-[2-(5-methylsulfanyl-thiophen-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-[2-(4,5-dimethyl-furan-2-yl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-butyl-N-[2-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-[2-(3-bromo-thiophen-2-yl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

5-{3-[acetyl-(2,6-dimethyl-phenyl)-amino]-6-methyl-imidazo[1,2-a]pyridin-2-yl}-thiophene-2-carboxylic acid,

N-butyl-N-[2-(2,3-dimethoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-tert-butyl-N-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-(2-furan-2-yl-5-propyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

5-[3-(acetyl-cyclohexyl-amino)-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-8-methyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

3-(acetyl-butyl-amino)-2-pyridin-2-yl-imidazo[1,2-a]pyridine-8-carboxylic acid,

{6-[acetyl-(5,7-dimethyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-tert-butyl-N-[2-(5-methylsulfanyl-thiophen-2-yl)-imidazo[1,2-a]pyrazin-3-yl]-acetamide,

5-[3-(acetyl-cyclohexyl-amino)-5-methyl-imidazo[1,2-a]pyridin-2-yl]-thiophene-2-carboxylic acid,

N-[2-(5-methylsulfanyl-thiophen-2-yl)-imidazo[1,2-a]pyrazin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-[2-(2,3-dichloro-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethyl-phenyl)-acetamide,

N-butyl-N-[2-(2-methoxy-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

(6-{acetyl-[2-(2-methoxy-phenyl)-6-nitro-imidazo[1,2-a]pyridin-3-yl]-amino}-hexyl)-methylidyne-ammonium,

N-(2-benzofuran-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(2,6-dimethylphenyl)-acetamide,

(6-{acetyl-[2-(2-methoxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-amino}-hexyl)-methylidyne-ammonium,

{6-[acetyl-(7-methyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethylbutyl)-acetamide,

acetic acid 5-{3-[acetyl-(2,6-dimethyl-phenyl)-amino]-5,7-dimethyl-imidazo[1,2-a]pyridin-2-yl}-furan-2-yl methyl ester,

{acetyl-[2-(3-hydroxy-phenyl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-amino}-acetic acid methyl ester,

N-tert-butyl-N-[2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-butyl-N-[2-(2-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-[2-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-N-(2,6-dimethylphenyl)-acetamide,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-7-methyl-imidazo[1,2-a]-pyrimidin-2-yl}-furan-2-carboxylic acid,

acetic acid 5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-imidazo[1,2-a]-pyrimidin-2-yl}-furan-2-yl methyl ester,

N-(2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

acetic acid 4-[3-(acetyl-cyclohexyl-amino)-5-amino-7-chloro-imidazo[1,2-a]-pyrimidin-2-yl]-2-methoxy-phenyl ester,

acetic acid 4-[3-(acetyl-cyclohexyl-amino)-5,7-dimethyl-imidazo[1,2-a]-pyrimidin-2-yl]-2-methoxy-phenyl ester,

N-[6-bromo-2-(2-chloro-6-fluoro-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

N-[2-(2-chloro-6-fluoro-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-N-cyclohexyl-acetamide,

N-butyl-N-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-[2-(5-chloro-thiophen-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

[acetyl-(2-cyclohexyl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-amino]-acetic acid methyl ester,

N-tert-butyl-N-[2-(2-chloro-6-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-(5,7-dimethyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

acetic acid 5-[3-(acetyl-cyclohexyl-amino)-5-methyl-imidazo[1,2-a]pyridin-2-yl]-furan-2-yl methyl ester,

N-(2,6-dimethyl-phenyl)-N-[6-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-(7-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-cyclohexyl-N-[2-(5-[1,3]dioxolan-2-yl-furan-2-yl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-tert-butyl-N-(5-propyl-2-pyridin-3-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-[2-(5-methyl-thiophen-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-2-furan-2-yl-imidazo[1,2-a]-pyridine-8-carboxylic acid,

N-tert-butyl-N-[2-(4,5-dimethyl-furan-2-yl)-6-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-{2-[3-(4-chloro-phenoxy)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-N-cyclohexyl-acetamide,

acetic acid 4-[3-(acetyl-cyclohexyl-amino)-imidazo[1,2-a]pyrimidin-2-yl]-2-methoxy-phenyl ester,

N-[2-(5-bromo-furan-2-yl)-8-methyl-imidazo[1,2-a]pyridin-3-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-(2,6-dimethyl-phenyl)-N-[2-(3-hydroxy-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

N-cyclohexyl-N-[2-(2,3-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-[2-(2,4-dichloro-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide,

N-cyclohexyl-N-[2-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

[acetyl-(2-o-tolyl-imidazo[1,2-a]pyrazin-3-yl)-amino]-acetic acid methyl ester,

N-tert-butyl-N-(6,8-dichloro-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

N-tert-butyl-N-(5-propyl-2-thiophen-2-yl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

{6-[acetyl-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-butyl-N-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

(6-{acetyl-[2-(2-methoxy-phenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-amino}-hexyl)-methylidyne-ammonium,

5-{3-[acetyl-(1,1,3,3-tetramethyl-butyl)-amino]-6-methyl-imidazo[1,2-a]-pyridin-2-yl}-furan-2-carboxylic acid,

N-butyl-N-[2-(3,4,5-trimethoxy-phenyl)-imidazo[1,2-a]pyrazin-3-yl]-acetamide,

N-butyl-N-[2-(3-hydroxy-phenyl)-imidazo[1,2-a]pyrimidin-3-yl]-acetamide,

[acetyl-(2-o-tolyl-imidazo[1,2-a]pyrimidin-3-yl)-amino]-acetic acid methyl ester,

N-(2-benzofuran-2-yl-8-methyl-imidazo[1,2-a]pyridin-3-yl)-N-(1,1,3,3-tetramethyl-butyl)-acetamide,

N-butyl-N-(7-methyl-2-p-tolyl-imidazo[1,2-a]pyrimidin-3-yl)-acetamide,

N-tert-butyl-N-(6,8-dibromo-2-methyl-imidazo[1,2-a]pyridin-3-yl)-acetamide,

{6-[acetyl-(5,7-dimethyl-2-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-amino]-hexyl}-methylidyne-ammonium,

N-tert-butyl-N-[2-(2-ethoxy-naphthalen-1-yl)-7-methyl-imidazo[1,2-a]-pyridin-3-yl]-acetamide,

N-tert-butyl-N-[2-(2-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide,

cyclohexyl-[7-methyl-2-(2-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine hydrochloride,

tert-butyl-(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

tert-butyl-(7-methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

cyclohexyl-(5,7-dimethyl-2-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-2-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

tert-butyl-(2,5,7-trimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

[2-(2-fluorophenyl)-7-methyl-imidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethyl-butyl)-amine hydrochloride,

cyclohexyl-(7-methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-2-yl-7-methyl-imidazo[1,2-a]pyrimidin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

tert-butyl-[2-(4-nitro-phenyl)-imidazo[1,2-a]pyrazin-3-yl]-amine hydrochloride,

N-{2-[3-(4-chlorophenoxy)-phenyl]-imidazo[1,2-a]pyridin-3-yl}-N-cyclohexyl-acetamide hydrochloride,

N-cyclohexyl-N-(7-methyl-2-o-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide hydrochloride,

N-(2,6-dimethyl-phenyl)-N-[2-(2,4-dimethyl-phenyl)-5-methyl-imidazo[1,2-a]pyridin-3-yl]-acetamide hydrochloride,

1-acetyl-3-(acetyl-cyclohexyl-amino)-7-methyl-2-o-tolyl-imidazo[1,2-a]-pyridin-1-ium) chloride hydrochloride,

cyclohexyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

cyclopentyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

[2-(4-bromo-2-fluoro-phenyl)-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl]-cyclopentyl-amine hydrochloride,

cyclopentyl-{5,7-dimethyl-2-[5-(2-nitro-phenyl)-furan-2-yl]-imidazo[1,2-a]-pyridin-3-yl}-amine hydrochloride,

{2-[5-(4-chlorophenyl)-furan-2-yl]-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl}-cyclopentyl-amine hydrochloride,

cyclopentyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-(11,1,3,3-tetramethylbutyl)-amine hydrochloride,

benzyl-(7-methyl-2-thiophen-3-yl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

cyclohexyl-(2-furan-3-yl-5,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)-amine hydrochloride,

(2-furan-3-yl-7-methyl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethylbutyl)-amine hydrochloride,

(5,7-dimethyl-2-thiophen-3-yl-imidazo[1,2-a]pyridin-3-yl)-(1,1,3,3-tetramethyl-butyl)-amine hydrochloride,

[7-ethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-(2-methoxybenzyl)-amine,

(2-chlorobenzyl)-[7-ethyl-2-(5-nitro-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-amine,

[7-ethyl-2-(5-methyl-furan-2-yl)-imidazo[1,2-a]pyridin-3-yl]-(2-methoxybenzyl)-amine,

(2-chlorobenzyl)-(7-ethyl-2-furan-2-yl-imidazo[1,2-a]pyridin-3-yl)-amine,

(3-chloro-4-fluorophenyl)-[7-ethyl-2-(5-methyl-furan-2-yl)-imidazo[1,2-a]-pyridin-3-yl]-amine,

(2-benzofuran-2-yl-7-ethyl-imidazo[1,2-a]pyridin-3-yl)-(3-chloro-4-fluorophenyl)-amine,

(2-benzofuran-2-yl-7-ethyl-imidazo[1,2-a]pyridin-3-yl)-(3-chlorophenyl)-amine,

(3-chloro-4-fluorophenyl)-{2-[5-(3-chloro-phenyl)-furan-2-yl]-7-ethyl-imidazo[1,2-a]pyridin-3-yl}-amine,

(3-chloro-4-fluorophenyl)-{2-[5-(2-chlorophenyl)-furan-2-yl]-7-ethyl-imidazo[1,2-a]pyridin-3-yl}-amine,

(3-chloro-4-fluorophenyl)-[2-(4,5-dimethyl-furan-2-yl)-7-ethyl-imidazo[1,2-a]pyridin-3-yl]-amine.

16. A method for treating one or more diseases selected from the group consisting of multiple sclerosis, Parkinson'"'"'s disease, Alzheimer'"'"'s disease, Huntington'"'"'s disease, cerebral ischaemia, diabetes, meningitis, and arteriosclerosis, or a method for healing wounds comprising administering an effective amount of a pharmaceutical composition according to claim 7 to a patient in need thereof.

18. A method for treating one or more diseases selected from the group consisting of multiple sclerosis, Parkinson'"'"'s disease, Alzheimer'"'"'s disease, Huntington'"'"'s disease, cerebral ischaemia, diabetes, meningitis, and arteriosclerosis, or a method for healing wounds, comprising administering an effective amount of a pharmaceutical composition according to claim 12 to a patient in need thereof.