Opioid pharmaceutical compositions
First Claim
1. ) A combination pharmaceutical preparation comprising:
- an opioid agonist analgesic;
a neutral receptor binding agent;
and, an acceptable pharmaceutical carrier thereof.
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Accused Products
Abstract
The invention is directed in part to dosage forms comprising a combination of an analgesically effective amount of an opioid agonist analgesic and a neutral receptor binding agent or a partial mu-opioid agonist, the neutral receptor binding agent or partial mu-opioid agonist being included in a ratio to the opioid agonist analgesic to provide a combination product which is analgesically effective when the combination is administered as prescribed, but which is less analgesically effective or less rewarding when administered in excess of prescription. Preferably, the combination product affects an opioid dependent individual differently from an opioid naïve individual, and has a diminished likelihood of being associated with a life-threatening adverse drug reaction, especially in the opioid dependent individual.
146 Citations
13 Claims
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1. ) A combination pharmaceutical preparation comprising:
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an opioid agonist analgesic;
a neutral receptor binding agent;
and, an acceptable pharmaceutical carrier thereof. - View Dependent Claims (3, 8, 10)
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2. ) A combination pharmaceutical preparation comprising:
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an opioid agonist analgesic;
a partial mu-opioid agonist;
and, an acceptable pharmaceutical carrier thereof. - View Dependent Claims (4, 9, 11)
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5. ) An opioid agonist analgesic composition comprising noroxycodone and a suitable pharmacological carrier thereof.
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6. ) A combination pharmaceutical preparation comprising:
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an opioid agonist analgesic;
CTAP;
and, an acceptable pharmaceutical carrier thereof. - View Dependent Claims (12)
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7. ) A combination pharmaceutical preparation comprising:
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an opioid agonist analgesic;
xorphanol;
and, an acceptable pharmaceutical carrier thereof. - View Dependent Claims (13)
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Specification