Spectroscopic unwanted signal filters for discrimination of vulnerable plaque and method therefor
First Claim
1. A method for analyzing blood vessels in the presence of intervening unwanted spectral signal, the method comprising:
- irradiating blood vessel walls through intervening fluid;
collecting spectral responses;
determining spectral responses of the blood vessel walls from the collected spectral responses; and
assessing states of the blood vessel walls in response to the determined spectral responses of the blood vessel walls.
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Accused Products
Abstract
Spectral variation contributed from the absorbance of unwanted correlated signals, such as blood at variable pathlengths between an in vivo catheter optic probe and a coronary vessel wall is an obstacle in the detection of vulnerable plaque. Preprocessing methods are described to reduce the impact of blood upon the spectral signal, based on the principles of Orthogonal Subspace Projection (OSP) and Generalized Least Square (GLS). The multivariate discrimination models used on the processed spectral information reduce the number of independent factors that include contributions from blood. The disclosed chemometric processing including preprocessing methods provide for in vivo spectral detection of medical analytes within the human body and in particular within the coronary vessel wall. A demonstration of how the preprocessing methods impact a discrimination modeling technique is provided, how the blood filters were developed and optimized, and finally how the OSP and GLS blood filters correct the spectral signal and improve the discrimination results of the models.
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Citations
73 Claims
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1. A method for analyzing blood vessels in the presence of intervening unwanted spectral signal, the method comprising:
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irradiating blood vessel walls through intervening fluid;
collecting spectral responses;
determining spectral responses of the blood vessel walls from the collected spectral responses; and
assessing states of the blood vessel walls in response to the determined spectral responses of the blood vessel walls. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A system for analyzing blood vessels in the presence of intervening fluid, the system comprising:
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a source of radiation;
a catheter for directing the radiation at blood vessel walls through intervening fluid and collecting radiation from the blood vessel walls;
a detector system of monitoring the collected radiation;
a controller for generating spectral responses from the collected radiation detected by the detector system;
an analyzer for determining spectral responses of the blood vessel walls from the collected spectral responses from the controller and generating information for assessment of the blood vessel walls in response to the determined spectral responses of the blood vessel walls. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method for de-emphasizing a blood response in a spectral response of a structure of interest, the method comprising:
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generating a filter determined by spectra representing a response of the blood which is collected at a relatively large distance from the structure of interest through the blood; and
applying the filter to a collected spectral response including the blood response to generate the spectral response of the structure of interest.
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43. A system for spectrally analyzing interior structures of animals in the presence of unwanted spectral signal sources, the system comprising:
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a source of radiation;
a catheter for directing the radiation at the interior structures through intervening medium and collecting radiation returning from the interior structures;
a detector system of monitoring radiation from the interior structures;
a spectrometer controller for generating spectral responses from the monitored radiation detected by the detector system;
an analyzer for determining spectral responses of the interior structures from the generated spectral responses from the spectrometer controller by removing a contribution of the medium and generating an assessment of a state of the internal structures in response to the determined spectral responses of the internal structures.
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44. A blood vessel analysis method comprising:
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collecting spectral responses of the blood vessels, the spectral responses including unwanted spectral signals;
processing the spectral responses to reduce the unwanted spectral signals relative to the blood vessel responses to generate determined spectral responses of the blood vessels;
using the determined spectral responses to analyze the blood vessels. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73)
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Specification