Device for in vivo delivery of bioactive agents and method of manufacture thereof
First Claim
Patent Images
1. An implantable body, comprising:
- a structural body having a three-dimensional conformation and a thickness thereto, at least one internal cavity residing within the thickness of the structural body, and at least one of a plurality of openings communicating between the at least one internal cavity and external to the structural body, and at least one bioactive agent disposed in the at least one internal cavity, the at least one bioactive agent capable of being released from within the at least one internal cavity through the at least one of a plurality of openings, upon implantation of the structural body into a body in need thereof.
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Abstract
The present invention consists of an implantable structural element for in vivo delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Alternatively, the implantable structural element may simply be an implantable article that serves the single function of acting as a time-release carrier for the bioactive agent.
132 Citations
14 Claims
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1. An implantable body, comprising:
a structural body having a three-dimensional conformation and a thickness thereto, at least one internal cavity residing within the thickness of the structural body, and at least one of a plurality of openings communicating between the at least one internal cavity and external to the structural body, and at least one bioactive agent disposed in the at least one internal cavity, the at least one bioactive agent capable of being released from within the at least one internal cavity through the at least one of a plurality of openings, upon implantation of the structural body into a body in need thereof. - View Dependent Claims (2, 3, 4)
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5. An endoluminal stent, comprising:
a tubular member having a central lumen passing longitudinally through the tubular member and open at opposing ends of the tubular member, a luminal surface and an abluminal surface and a wall thickness defined therebetween, at least one internal cavity residing within the wall thickness in at least some portions of the tubular member, a plurality of openings communicating between the at least one internal cavity and at least one of the luminal surface, abluminal surface, proximal end or distal end of the tubular member, and at least one bioactive agent disposed in the at least one internal cavity. - View Dependent Claims (6, 7)
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8. An endoluminal stent, comprising:
a cylindrical member comprised of a plurality of structural elements defining walls of the cylindrical member, a plurality of discontinuous interior cavities disposed in at least some of the plurality of structural elements, and a plurality of openings communicating between each of the plurality of discontinuous interior cavities and external the stent, and at least one bioactive agent disposed within the plurality of discontinuous interior cavities. - View Dependent Claims (9, 10)
- 11. An endoluminal stent for delivering a bioactive agent to a situs in a body, comprising a plurality of structural elements interconnected to form a cylindrical member, each of the plurality of structural elements a the wall thickness further comprising a plurality of lamina positioned concentrically through the wall thickness and a plurality of tubular member having an exterior surface and an interior surface together defining a tubular member thickness of said tubular member, said tubular member having a recessed active agent receiving portion formed in said exterior surface, said recessed active agent receiving portion having a depth less than said tubular member thickness, said recessed active agent receiving portion containing at least one active agent.
Specification