Valved prostheses with preformed tissue leaflets
First Claim
1. A valved prosthesis comprising a plurality of leaflets each of which comprises crosslinked tissue having a shape corresponding to a contoured surface, the leaflets being individually attached to the prosthesis.
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Abstract
Valved prostheses are described with crosslinked leaflets. At least one of the leaflets has a shape corresponding to a contoured surface. The leaflets are individually attached to the prostheses. Furthermore, in some embodiments, the leaflets do not comprise native leaflet tissue. Methods for forming tissue heart valve prostheses can comprise assembling a plurality of leaflets configured to open and close the valve in response to pressure differentials. Each of the plurality of leaflets is preformed individually when at least partially crosslinked in contact with a contoured surface. The individual crosslinked leaflets can be selected and matched for assembly into a valve. In general, the tissue, when it is crosslinked, has a size and shape approximately the size of a single human heart valve leaflet.
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Citations
49 Claims
- 1. A valved prosthesis comprising a plurality of leaflets each of which comprises crosslinked tissue having a shape corresponding to a contoured surface, the leaflets being individually attached to the prosthesis.
- 21. A method for forming a valved prosthesis, the method comprising assembling a plurality of leaflets configured to open and close the valve in response to pressure differentials, wherein each leaflet is preformed when crosslinked individually in contact with a contoured surface.
- 34. A method for forming a leaflet for a valved prosthesis, the method comprising crosslinking a tissue segment having the approximate size of a single human heart valve leaflet wherein the crosslinking is performed in contact with a contoured surface.
- 44. A tissue segment comprising crosslinked tissue having the shape and size of a single human heart valve leaflet wherein the leaflets do not comprise native leaflet tissue.
Specification