Drug delivery system including holder and drug container
First Claim
1. A system for delivering at least one substance in at least two doses, comprising:
- a drug container including a barrel, a first end extending from said barrel, and a stopper slidably positioned within said barrel;
a holder having a distal portion and a proximal portion, with the distal portion being assembled to the proximal portion, with the drug container secured therein; and
means for controlling the delivery of a substance contained in the barrel of the drug container including a plurality of slots extending axially along at least one of said portions of the holder whereby upon activation of said system, said portions of said holder move towards one another upon the application of a minimum force and said stopper moves a preselected axial distance to expel at least a portion of said substance from said drug container.
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Accused Products
Abstract
A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like is provided. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is securely retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system. A plurality of slots are provided for controlling the delivery of a substance and extend axially along at least one portion of the holder whereby upon activation of the system, the portions of the holder move towards one another upon the application of a minimum force and the stopper moves a preselected axial distance to expel at least a portion of the substance from the drug container. One application is to a nasal drug container, where approximately equal doses of the substance are desired to be administered to each nostril of the patient.
51 Citations
76 Claims
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1. A system for delivering at least one substance in at least two doses, comprising:
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a drug container including a barrel, a first end extending from said barrel, and a stopper slidably positioned within said barrel;
a holder having a distal portion and a proximal portion, with the distal portion being assembled to the proximal portion, with the drug container secured therein; and
means for controlling the delivery of a substance contained in the barrel of the drug container including a plurality of slots extending axially along at least one of said portions of the holder whereby upon activation of said system, said portions of said holder move towards one another upon the application of a minimum force and said stopper moves a preselected axial distance to expel at least a portion of said substance from said drug container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 76)
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24. A holder for a drug container, comprising;
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a distal portion and a proximal portion, each having configured to accommodate a drug container filled with a substance to be delivered, with the distal portion being able to be assembled to the proximal portion; and
means for controlling the delivery of the substance including a plurality of slots extending axially along at least one of said portions of the holder whereby when said portions of said holder are moved towards one another upon the application of a minimum force, at least a portion of the substance can be expelled from said drug container. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A system for the nasal delivery of at least one substance, comprising:
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a syringe including a barrel, a first end extending from said barrel, said first end including a spray nozzle having an opening for dispensing the substance from said barrel, and at least one stopper slidably positioned within said barrel;
a holder having a distal portion and a proximal portion, each having a generally tubular interior configuration to accommodate said syringe, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the system; and
means for controlling the delivery of a substance including a plurality of slots extending axially along at least one of said portions of the holder whereby upon activation of said system, said portions of said holder move towards one another upon the application of a minimum force and said stopper moves a preselected axial distance to expel at least a portion of said substance from said syringe, with said preselected axial distance corresponding to about half the distance that said stopper is capable of moving within said barrel to administer about half of the substance contained by said syringe barrel. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A method of intranasally delivering at least one substance in at least two doses, comprising the steps of:
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grasping a pre-assembled drug delivery system with a thumb and two forefingers of one hand, said drug delivery system including a drug container and a holder, with the drug container including a barrel, a first end extending from the barrel, and a stopper slidably positioned within the barrel and the holder having a distal portion and a proximal portion, with the distal portion being assembled to the proximal portion, with the drug container secured therein, and the proximal portion acting as a plunger rod during activation of the system;
inserting the end of said drug container into one nostril of a person to whom the substance is to be intranasally delivered;
squeezing together the thumb and two forefingers of the one hand to apply sufficient force to overcome a bridge extending at least partially across a slot to insure the application of a minimum force;
moving the proximal portion of the holder towards the distal portion of the holder a first predetermined distance during a first motion as a result of continuing to squeeze together the thumb and two forefingers to cause the displacement of the stopper and expulsion of a first predetermined amount of a substance contained in the chamber of the drug container barrel into said nostril;
removing the end of said drug container from said nostril while relaxing the squeezing force being applied and inserting the end of said drug container into another nostril of the person to whom the substance is to be intranasally delivered;
squeezing together the thumb and two forefingers to apply sufficient force to overcome a second bridge extending at least partially across the slot to insure the application of a minimum force; and
moving the proximal portion of the holder towards the distal portion of the holder a second predetermined distance during a second motion as a result of continuing to squeeze together the thumb and two forefingers to cause the displacement of the stopper and expulsion of a second predetermined amount of the substance contained in the chamber of the drug container barrel into said other nostril. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
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Specification