Antioxidant sensor

• US 20040026244A1
• Filed: 07/31/2003
• Published: 02/12/2004
• Est. Priority Date: 11/16/1995
• Status: Abandoned Application

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Chatelier, Ron, Hodges, Alastair
• Application Number:
  US10/632,947
• Publication Number:
  US 20040026244A1
• Time in Patent Office: Days
• US Class Current: 204/409
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 33/84 involving inorganic compounds or pH

Abstract

The present invention relates to a device and method for measuring the level of an oxidant or antioxidant analyte in a fluid sample. The device comprises a disposable electrochemical cell, such as a thin layer electrochemical cell, containing a reagent capable of undergoing a redox reaction with the analyte. When the device or method is to be used with slow-reacting analytes, heat may be applied to the sample by a resistive heating element in the device or by an exothermic material contained within the electrochemical cell. Application of heat will accelerate the rate of the redox reaction between the reagent and the analyte and thus facilitate the electrochemical measurement of slow-reacting analytes.

Claims

1. A device for detecting a presence or an absence of a redox reactive analyte in an aqueous sample, the device comprising an electrochemical cell having a sensing chamber, a first electrode, a second electrode, an aperture for admitting the sample into the sensing chamber, and a reagent contained within the sensing chamber, wherein the device contains a quantity of the reagent sufficient for only a single test, and wherein the reagent is capable of undergoing a redox reaction directly with the analyte to generate an electrical signal indicative of the presence or absence of the analyte.

2. The device of claim 1, wherein the first electrode comprises a sensing electrode.

3. The device of claim 1, wherein the first electrode comprises a material selected from the group consisting of platinum, palladium, carbon, indium oxide, tin oxide, gold, iridium, copper, steel, silver, and mixtures thereof.

4. The device of claim 1, wherein the second electrode comprises a counter electrode.

5. The device of claim 1, wherein the second electrode comprises a metal in contact with a metal salt.

6. The device of claim 5, wherein the metal in contact with a metal salt is selected from the group consisting of silver in contact with silver chloride, silver in contact with silver bromide, silver in contact with silver iodide, mercury in contact with mercurous chloride, and mercury in contact with mercurous sulfate.

7. The device of claim 1, the electrochemical cell further comprising a reference electrode.

8. The device of claim 1, wherein the reagent is capable of oxidizing an analyte comprising an antioxidant.

9. The device of claim 8, wherein the reagent is selected from the group consisting of ferricyanide salts, dichromate salts, permanganate salts, vanadium oxides, dichlorophenolindophenol, osmium bipyridine complexes, and quinones.

10. The device of claim 1, wherein the reagent is capable of reducing an analyte comprising an oxidant.

11. The device of claim 10, wherein the reagent is selected from the group consisting of iodine, triiodide salts, ferrocyanide salts, ferrocene, Cu(NH₃)₄²⁺ salts, and Co(NH₃)₆³⁺ salts.

12. The device of claim 1, the sensing chamber further comprising a buffer, wherein the buffer is contained within the sensing chamber.

13. The device of claim 12, wherein the buffer is selected from the group consisting of phosphates, carbonates, alkali metal salts of mellitic acid, and alkali metal salts of citric acid.

14. The device of claim 1, further comprising a heating element.

15. The device of claim 14, wherein the heating element is an electrically resistive heating element.

16. The device of claim 14, wherein the heating element is an exothermic substance contained within the sensing chamber.

17. The device of claim 1, wherein the second electrode is mounted in opposing relationship a distance of less than about 150 microns from the first electrode.

18. The device of claim 1, further comprising an interface for communication with a meter.

19. The device of claim 18, wherein the interface communicates a voltage or a current.

20. The device of claim 1, wherein the electrochemical cell comprises a thin layer electrochemical cell.