4 dimensinal magnetic resonance imaging
First Claim
1. Apparatus for providing a multidimensional image of inanimate or animate objects comprising:
- a magnetization source for producing a magnetic field to magnetize a volume of an object to be imaged, the volume comprising a plurality of voxels;
a radiation source for applying a radiation field to the object to be imaged when the object is disposed in the magnetic field to produce a secondary radiation field emanating from the object;
an output signal detector for producing output signals in response to said secondary radiation at a plurality of spatial locations outside of the object as a function of time;
a first processor for determining a plurality of Fourier components, each having the same frequency, an intensity and a phase angle;
a second processor for associating the Fourier components due to each voxel of the object to be imaged by phase to form a set corresponding to a spatial variation of intensity of the secondary radiation due to each voxel at said plurality of spatial locations outside of the object;
a third processor for converting each said set of components into a voxel location; and
an image processor for producing an image based on the secondary radiation intensity from each voxel and the location of each voxel.
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Abstract
Provided are apparatus and methods for forming a multidimensional image of inanimate or animate objects which utilize a magnetization source (112) to magnetize a volume of an object to be imaged, a radiation source (118) for applying a radiation field to the object to be imaged, an output signal detector (120) for producing output signals in response to the secondary radiation at a plurality of spatial locations outside of the object as a function of time, processors (126, 126a and 126b) for determining a plurality of Fourier components, for associating the Fourier components due to each voxel (14) by phase, and for converting each set of components into a voxel location, and an image processor (128) for producing an image.
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Citations
167 Claims
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1. Apparatus for providing a multidimensional image of inanimate or animate objects comprising:
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a magnetization source for producing a magnetic field to magnetize a volume of an object to be imaged, the volume comprising a plurality of voxels;
a radiation source for applying a radiation field to the object to be imaged when the object is disposed in the magnetic field to produce a secondary radiation field emanating from the object;
an output signal detector for producing output signals in response to said secondary radiation at a plurality of spatial locations outside of the object as a function of time;
a first processor for determining a plurality of Fourier components, each having the same frequency, an intensity and a phase angle;
a second processor for associating the Fourier components due to each voxel of the object to be imaged by phase to form a set corresponding to a spatial variation of intensity of the secondary radiation due to each voxel at said plurality of spatial locations outside of the object;
a third processor for converting each said set of components into a voxel location; and
an image processor for producing an image based on the secondary radiation intensity from each voxel and the location of each voxel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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78. Apparatus for providing a multidimensional image of inanimate or animate objects comprising:
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means for producing a magnetic field to magnetize a volume of an object to be imaged, the volume comprising a plurality of voxels;
means for applying a radiation field to the object to be imaged when the object is disposed in the magnetic field to produce a secondary radiation field emanating from the object;
means for producing output signals in response to said secondary radiation at a plurality of spatial locations outside of the object as a function of time;
first processor means for determining a plurality of Fourier components, each having the same frequency, an intensity and a phase angle;
second processor means for associating the Fourier components due to each voxel of the object to be imaged by phase to form a set corresponding to a spatial variation of intensity of the secondary radiation due to each voxel at said plurality of spatial locations outside of the object;
third processor means for converting each said set of components into a voxel location; and
image processor means for producing an image based on the secondary radiation intensity from each voxel and the location of each voxel.
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79. An apparatus for providing a two dimensional or three-dimensional nuclear magnetic resonance image of an object comprising:
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means for generating an image from a three-dimensional map of a transverse resonant radio frequency magnetic flux external to an object having a volume to be imaged, the volume comprising a plurality of voxels; and
processor means for determining the location of each voxel which is a source of the radio frequency field through spatial variations of an intensity of the nuclear magnetic resonance field of a set of components associated by phase.
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80. An apparatus for providing a two dimensional or three-dimensional nuclear magnetic resonance image of an object comprising:
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a magnetizing source for magnetizing a volume an object in a first direction, the volume comprising a plurality of voxels;
means for causing nuclear magnetic resonance magnetization to rotate into a plane transverse to the first direction;
an output signal detector for detecting the nuclear magnetic resonance field rotated into a transverse plane external to the object at a plurality of spatial locations;
a first processor for determining a set of components of spatial variation of the nuclear magnetic resonance field over a sample volume by association of the components by phase;
a second processor for determining a location of each voxel which is a source of the radio frequency field through each set of components representative of spatial variations of an intensity of the nuclear magnetic resonance field over the sample volume, and an image processor for displaying the voxel locations representative of anatomical images of the object based on selected physiological.
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81. An apparatus for providing a two dimensional or three-dimensional nuclear magnetic resonance image of an object comprising:
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means for magnetizing a volume an object in a first direction, the volume comprising a plurality of voxels;
means for causing nuclear magnetic resonance magnetization to rotate into a plane transverse to the first direction;
means for detecting the nuclear magnetic resonance field rotated into a transverse plane external to the object over a sample volume comprising a plurality of spatial locations;
processor means for determining a set of components of spatial variation of the nuclear magnetic resonance field over a sample volume by association of the components by phase;
processor means for determining a location of each voxel which is a source of the radio frequency field through each set of components representative of spatial variations of an intensity of the nuclear magnetic resonance field over the sample volume, and processor means for displaying the voxel locations representative of anatomical images of the object based on selected physiological parameters.
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82. An apparatus for providing a two dimensional or three-dimensional nuclear magnetic resonance image of an object comprising:
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means for generating an image from a three-dimensional map of a transverse resonant radio frequency magnetic flux external to an object comprising a volume to be imaged, the volume comprising a plurality of voxels; and
processor means for determining locations of voxels, which is a source of a radio frequency field through spatial variations of an intensity of a nuclear magnetic resonance field of a set of components associated by phase.
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83. A method for providing a multidimensional image of inanimate and animate objects comprising the steps of:
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placing an object having a volume in a magnetic field, the volume comprising a plurality of voxels;
applying a first source of radiation to the object;
recording a secondary source of radiation emanating from the object at a plurality of spatial locations;
forming components of the spatial variation of the secondary source of radiation external to the object due to voxels of the object;
determining the location of voxels from the intensity variation of the components;
generating and displaying the image from the locations and the intensity of the secondary radiation of each voxel. - View Dependent Claims (84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 97, 98, 99, 100, 101, 102, 150, 151)
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94. A method for providing a multidimensional image of inanimate and animate objects comprising the steps of:
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magnetizing a volume of an object to be imaged, the volume comprising a plurality of voxels;
applying a radiation field to the object to be imaged when disposed in the magnetic field to produce a secondary radiation field emanating from the object;
producing output signals from a detector in response to said secondary radiation at a plurality of spatial locations outside of the object as a function of time;
determining a plurality of Fourier components each having the same frequency, an intensity and a phase angle;
associating the Fourier components due to each voxel of the object to be imaged by phase to form a set corresponding to the spatial variation of intensity of the secondary radiation due to each voxel at the plurality of spatial locations outside of the object;
converting each set of components into a voxel location; and
producing an image based on an intensity of the secondary radiation from each voxel, the location of each voxel, and plotting the superposition of results for each voxel.
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95. A method for providing a two dimensional or three-dimensional nuclear magnetic resonance image of an object comprising the steps of:
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generating an image from a three-dimensional map of a transverse resonant radio frequency magnetic flux external to a volume of an object being scanned, the volume comprising a plurality of voxels, characterized in that a nuclear magnetic resonance signal of each voxel at any given detector gives rise to a Fourier component with a unique phase angle relative to the Fourier component of any other voxel of the object at a detector;
a set of Fourier components that correspond to a nuclear magnetic resonance signal of a given voxel over detectors is determined;
an intensity variation of the transverse radio frequency field over space is used to determine a coordinate location of each voxel; and
a superposition of results for each voxel is plotted to provide a total image.
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96. A method of providing a multidimensional image of inanimate and animate objects comprising the steps of:
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aligning magnetic moments of nuclei of a volume of an object to be imaged using a primary field, the volume comprising a plurality of voxels;
further aligning the magnetic moments by a radio frequency pulse or series of pulses;
recording free induction decay signals;
Fourier transforming time dependent nuclear magnetic resonance signals to give intensity and phase of each Fourier component, characterized in that nuclear magnetic resonance signal of each voxel at any given detector gives rise to a Fourier component with a unique phase angle relative to the Fourier component of any other voxel at that detector;
determining a matrix of Fourier components that correspond to the nuclear magnetic resonance signal of a given voxel over the detectors;
determining matrices for a plurality of voxels;
determining a coordinate location of each voxel from measurements of spatial variations of a transverse radio frequency field of each corresponding matrix; and
processing and displaying the position of each voxel with a representation of the intensity of the nuclear magnetic resonance signal emitted by each voxel. - View Dependent Claims (103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 138, 139, 140, 141, 142, 143, 144, 145, 146, 148, 149, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167)
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127. A method of providing a multidimensional image of inanimate and animate objects comprising the steps of:
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a.) recording secondary radiation signals corresponding to a transverse radio frequency magnetic field in response to a first radiation applied to a magnetized object over a sample volume comprising a plurality of voxels;
b.) forming a matrix of signals at a plurality of spatial positions each corresponding to a detector element of a detector array;
c.) transforming the matrix numeric values according to a Fourier transform to give an intensity and phase of each component wherein a nuclear magnetic resonance signal of each voxel at any given detector gives rise to a Fourier component with a unique phase angle relative to the Fourier component of any other voxel of the object at that detector;
d.) determining a matrix of Fourier components that correspond to the nuclear magnetic resonance signal of a given voxel over the detectors;
e.) multiplying each numeric value of the transform array by a value which is an inverse or reciprocal of the Fourier transform of a waveform corresponding to an operation performed in step b;
f.) multiplying each numeric value of the discrete spectrum matrix by a value corresponding to an inverse Fourier transform of a function representative of the steps of exciting and detecting and providing a system corrected matrix;
g.) inverse-transforming the system corrected matrix according to a multidimensional discrete inverse Fourier transform providing a voxel location;
h.) correcting each element in the transformed matrix for any asymmetries in the dimensions of the sample volume;
i.) repeating steps c-h for other matrices, each corresponding to a distinct voxel; and
j.) superimposing the results from steps a-h, plotting and displaying the image. - View Dependent Claims (128, 129, 130, 131, 132, 133, 134, 135, 136, 137)
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147. A method of providing a multidimensional nuclear magnetic resonance image of an animate or inanimate object comprising the steps of:
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placing a volume of an object having nuclei in a static magnetic field H0, the volume comprising a plurality of voxels, and then subjected them to an additional rotating radio frequency field H1, which is synchronous with their precession, such that the bulk magnetization M of each voxel of the object precesses about H1 and rotates away from the primary field H0 by an angle φ
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measuring of the intensity of the radio frequency signal over time and space following T1 and/or T2 encoding pulses wherein the magnitude of M is a maximum initially and decays with time by emission of the same multipolarity radiation that it absorbed and by transfer of energy to the surrounding lattice and the intensity of the radiation is a function of M and the coordinate position relative to the radio frequency emitting voxel;
Fourier transforming the signal as a function of time at a given detector position to give the components each having an amplitude and a unique phase;
determining each set of components of the nuclear magnetic resonance signal over the sample volume due to a given voxel from the phase data and the detector positions;
determining the location of each voxel through the spatial variations of the intensity of the transverse nuclear magnetic resonance field of the set of components associated by phase; and
superimposing the results of the determination of the location of M of each voxel and the plotting and displaying the resulting image.
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Specification