Spheron components useful in determining compounds capable of treating symptoms of Alzheimer's disease, and treatments and animal models produced therefrom
First Claim
Patent Images
1. A composition comprising:
- at least one compound that binds to, antagonizes, or competes with a spheron component peptide other than a spheron component responsible for forming amyloid plaque, the spheron component peptide being selected from one or more of the group consisting of;
(SEQ ID NO.
wherein the spheron component peptide has been racemized.
1) a)GEAAGAVQELAR;
(SEQ ID NO.
2) b)GLSAASPPLAETGAPR;
(SEQ ID NO.
3) c)ARAEAQEAEDQQAR;
(SEQ ID NO.
4) d)VLAQLLR;
(SEQ ID NO.
5) e)ALAHLLEAERQER;
(SEQ ID NO.
6) f)AADHDVGSELPPEGVLGALLR;
(SEQ ID NO.
7) g)LETPAPQVPAR;
(SEQ ID NO.
8) h)ILAGSADSEGVAAPR;
(SEQ ID NO.
9) i)ARPVKEPRGLSAASPPLAETGAPRRF;
(SEQ ID NO.
10) j)ARPVKEP;
(SEQ ID NO.
11) k)GLSAASPPLAETGAPRRF;
(SEQ ID NO.
12) l)AADHDVGSELPPEGVLGALLRVKRLETPAPQVPA;
(SEQ ID NO.
13) m)AADHDVGSELPPEGVLGALLRV;
(SEQ ID NO.
14) n)LETPAPQVPA;
(SEQ ID NO.
15) o)RRSVPRGEAAG;
(SEQ ID NO.
16) p)VLAQLLRVWGAPRNSD;
(SEQ ID NO.
17) q)PALGLDDDPDAPAAQLAR;
(SEQ ID NO.
18) r)LARALLRARLDPAALAA;
(SEQ ID NO.
19) s)QLVPAPVPAAALRPRPPVYDD;
(SEQ ID NO.
20) t)GPAGPDAEEAGDE;
(SEQ ID NO.
21) u)TPDVDPELLRYLLGR;
(SEQ ID NO.
22) v)LLRVKR; and
(SEQ ID NO.
23) w)VLGALLRVKRLE,
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Accused Products
Abstract
The present invention relates to racemized proteins and racemized protein components of spherons that are useful for identifying compounds capable of preventing and/or ameliorating symptoms of Alzheimer'"'"'s Disease and/or dementia associated with cerebral amyloidosis. The invention also relates to the compounds identified by the methods, and methods of treating and/or ameliorating symptoms of Alzheimer'"'"'s Disease and/or dementia associated with cerebral amyloidosis. The invention also relates to methods of making an Alzheimer'"'"'s Disease or dementia associated with cerebral amyloidosis animal model or test animal, the animal model produced therefrom, and to a method of using the animal model to screen for effective therapies.
21 Citations
31 Claims
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1. A composition comprising:
-
at least one compound that binds to, antagonizes, or competes with a spheron component peptide other than a spheron component responsible for forming amyloid plaque, the spheron component peptide being selected from one or more of the group consisting of;
(SEQ ID NO.
1)a) GEAAGAVQELAR; (SEQ ID NO.
2)b) GLSAASPPLAETGAPR; (SEQ ID NO.
3)c) ARAEAQEAEDQQAR; (SEQ ID NO.
4)d) VLAQLLR; (SEQ ID NO.
5)e) ALAHLLEAERQER; (SEQ ID NO.
6)f) AADHDVGSELPPEGVLGALLR; (SEQ ID NO.
7)g) LETPAPQVPAR; (SEQ ID NO.
8)h) ILAGSADSEGVAAPR; (SEQ ID NO.
9)i) ARPVKEPRGLSAASPPLAETGAPRRF; (SEQ ID NO.
10)j) ARPVKEP; (SEQ ID NO.
11)k) GLSAASPPLAETGAPRRF; (SEQ ID NO.
12)l) AADHDVGSELPPEGVLGALLRVKRLETPAPQVPA; (SEQ ID NO.
13)m) AADHDVGSELPPEGVLGALLRV; (SEQ ID NO.
14)n) LETPAPQVPA; (SEQ ID NO.
15)o) RRSVPRGEAAG; (SEQ ID NO.
16)p) VLAQLLRVWGAPRNSD; (SEQ ID NO.
17)q) PALGLDDDPDAPAAQLAR; (SEQ ID NO.
18)r) LARALLRARLDPAALAA; (SEQ ID NO.
19)s) QLVPAPVPAAALRPRPPVYDD; (SEQ ID NO.
20)t) GPAGPDAEEAGDE; (SEQ ID NO.
21)u) TPDVDPELLRYLLGR; (SEQ ID NO.
22)v) LLRVKR; and (SEQ ID NO.
23)w) VLGALLRVKRLE, wherein the spheron component peptide has been racemized. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of identifying compounds useful in treating or ameliorating a neurological condition comprising:
-
transforming, transfecting or infecting cells, the transformed, transfected or infected cells comprising;
(a) a spheron component peptide other than a spheron component responsible for forming amyloid plaque;
(b) a polynucleotide encoding for a spheron component peptide other than a spheron component responsible for forming amyloid plaque;
or(c) a polynucleotide that hybridizes under stringent conditions to (b);
administering a test compound to the transformed, transfected or infected cells; and
identifying the compounds that ameliorate the effects of the spheron component other than a spheron component responsible for forming amyloid plaque, wherein the spheron component peptide other than a spheron component responsible for forming amyloid plaque is selected from the group consisting of;
(SEQ ID NO.
1)a) GEAAGAVQELAR; (SEQ ID NO.
2)b) GLSAASPPLAETGAPR; (SEQ ID NO.
3)c) ARAEAQEAEDQQAR; (SEQ ID NO.
4)d) VLAQLLR; (SEQ ID NO.
5)e) ALAHLLEAERQER; (SEQ ID NO.
6)f) AADHDVGSELPPEGVLGALLR; (SEQ ID NO.
7)g) LETPAPQVPAR; (SEQ ID NO.
8)h) ILAGSADSEGVAAPR; (SEQ ID NO.
9)i) ARPVKEPRGLSAASPPLAETGAPRRF; (SEQ ID NO.
10)j) ARPVKEP; (SEQ ID NO.
11)k) GLSAASPPLAETGAPRRF; (SEQ ID NO.
12)l) AADHDVGSELPPEGVLGALLRVKRLETPAPQVPA; (SEQ ID NO.
13)m) AADHDVGSELPPEGVLGALLRV; (SEQ ID NO.
14)n) LETPAPQVPA; (SEQ ID NO.
15)o) RRSVPRGEAAG; (SEQ ID NO.
16)p) VLAQLLRVWGAPRNSD; (SEQ ID NO.
17)q) PALGLDDDPDAPAAQLAR; (SEQ ID NO.
18)r) LARALLRARLDPAALAA; (SEQ ID NO.
19)s) QLVPAPVPAAALRPRPPVYDD; (SEQ ID NO.
20)t) GPAGPDAEEAGDE; (SEQ ID NO.
21)u) TPDVDPELLRYLLGR; (SEQ ID NO.
22)v) LLRVKR; and (SEQ ID NO.
23)w) VLGALLRVKRLE, wherein the spheron component peptide has been racemized. - View Dependent Claims (15, 16, 17)
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- 18. A protein comprising one or more spheron component peptides selected from the group consisting of:
Specification
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- Resources
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Current AssigneeNymox Corporation
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Original AssigneeNymox Corporation
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InventorsAverback, Paul
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Granted Patent
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Time in Patent OfficeDays
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Field of Search
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US Class Current514/14
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CPC Class CodesA01K 2217/05 Animals comprising random i...A61P 25/28 for treating neurodegenerat...A61P 43/00 Drugs for specific purposes...C07K 14/4702 Regulators; Modulating acti...C07K 14/4711 Alzheimer's disease; Amyloi...C07K 7/06 having 5 to 11 amino acidsC07K 7/08 having 12 to 20 amino acids...
