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Method for the diagnosis of genetic diseases by molecular combing and diagnostic kit

  • US 20040033510A1
  • Filed: 03/11/2003
  • Published: 02/19/2004
  • Est. Priority Date: 10/30/1996
  • Status: Active Grant
First Claim
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1. Method for detecting the presence or the location of one or more genes or of one or more sequences of specific A DNA or of one or more molecules reacting with the DNA on a B DNA, characterized in that:

  • (a) a certain quantity of said B DNA is attached to and combed on a combing surface, (b) the B combing product is reacted with one or more labeled probes, bound to the gene(s) or to the sequences of specific A DNA(s) or to the molecules capable of reacting with the DNA, (c) the information corresponding to at least one of the following categories is extracted;

    (1) the position of the probes, (2) the distance between probes, (3) the size of the probes (the total sum of the sizes which make it possible to quantify the number of hybridized probes) so as to deduce therefrom the presence, the location and/or the quantity of the genes or of the sequences of specific A DNA.

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