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Method for gold deposition

  • US 20040033626A1
  • Filed: 08/11/2003
  • Published: 02/19/2004
  • Est. Priority Date: 10/27/1998
  • Status: Active Grant
First Claim
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1. A method of detecting a nucleic acid having at least two portions comprising:

  • (a) contacting the nucleic acid with a substrate having oligonucleotides attached thereto, the oligonucleotides being located between a pair of electrodes, the oligonucleotides having a sequence complementary to a first portion of the sequence of said nucleic acid, the contacting taking place under conditions effective to allow hybridization of the oligonucleotides on the substrate with said nucleic acid;

    (b) contacting said nucleic acid bound to the substrate with a first type of particle, the particles being made of a material which can conduct electricity, the particles having an oligonucleotide with a sequence complementary to a second portion of the sequence of said nucleic acid, the contacting taking place under conditions effective to allow hybridization of the oligonucleotides on the particles with said nucleic acid; and

    (c) detecting a change in conductivity.

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