Methods and compositions for preventing chronological aging in human skin
First Claim
1. A method for delaying the decrease in collagen inherent in naturally-aged (chronologically-aged) human skin, comprising:
- providing a composition including a non-toxic amount of retinoid in a cosmetically suitable vehicle and applying said composition to the skin on a regular basis in an amount effective to delay both the decrease in procollagen biosynthesis and the increase in enzymatic collagen degradation inherent in naturally-aged human skin.
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Abstract
Chronological aging of human skin can be delayed with the topical application of an MMP inhibitor, preferably a retinoid (an indirect MMP inhbitor); retinoids also normalize procollagen biosynthesis. Chronological aging, or natural aging, is evidenced in elderly (80+ years old) skin by increased MMP levels and decreased procollagen levels when compared with younger individuals. Prophylactic treatment of not yet chronologically-aged skin with a retinoid both inhibits degradation of dermal collagen and restores procollagen synthesis. Biopsied sections from elderly skin show that a single treatment of chronologically-aged skin with a retinoid can increase epidermal thickness, improve the dermal collagen density, and promote the formation of rete pegs and dermal papillae. Such benefits are helpful in preventing bruising, tearing, and ulceration of elderly skin. Accordingly, prophylactic treatment begun much earlier in life with an MMP inhibitor and/or a retinoid delays the onset of such symptoms.
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Citations
18 Claims
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1. A method for delaying the decrease in collagen inherent in naturally-aged (chronologically-aged) human skin, comprising:
- providing a composition including a non-toxic amount of retinoid in a cosmetically suitable vehicle and applying said composition to the skin on a regular basis in an amount effective to delay both the decrease in procollagen biosynthesis and the increase in enzymatic collagen degradation inherent in naturally-aged human skin.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- 12. A method for delaying the increase in collagen degradation inherent in naturally-aged (chronologically-aged) human skin, comprising, providing a composition including a non-toxic amount of non-retinoid MMP inhibitor in a cosmetically-suitable vehicle and applying said composition to the skin on a regular basis in an amount effective to delay the increase in enzymatic collagen degradation inherent in naturally-aged human skin.
Specification