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Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus

  • US 20040038867A1
  • Filed: 06/13/2003
  • Published: 02/26/2004
  • Est. Priority Date: 06/13/2002
  • Status: Active Grant
First Claim
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1. A method for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein:

  • i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and

    ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.

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