Preparation for transmission and reception of electrical signals
First Claim
1. A method for enhancing the transmission and reception of electrical signals through a tissue site comprising the steps of:
- applying ultrasound to a tissue site to decrease an impedance of said tissue site, and affixing an electrode in proximity to said tissue site.
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Accused Products
Abstract
The invention provides a convenient and non-invasive means to prepare cells, tissues, and organs for electrical transmission and reception. In an embodiment of the invention, a control method comprises the use of at least one skin electrode, as a reference electrode, and an electrical sensor to measure periodically or continuously the skin'"'"'s electrical conductance at the site of preparation. The dynamic change in the conductance through the skin is measured while the ultrasound is applied. Signal processing is performed on the measurement and the level of skin impedance change is controlled by performing a mathematical analysis and using the results of such analysis to control the application of ultrasonic energy. A desired level of skin impedance can be set at a predetermined value or based on a chosen level of skin integrity, subject'"'"'s sensation of discomfort, or duration of the ultrasound application.
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Citations
47 Claims
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1. A method for enhancing the transmission and reception of electrical signals through a tissue site comprising the steps of:
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applying ultrasound to a tissue site to decrease an impedance of said tissue site, and affixing an electrode in proximity to said tissue site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A tissue interface receptacle comprising:
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a top surface, wherein said top surface is configured to receive an ultrasound applicator;
a bottom surface, wherein said bottom surface is configured to be affixed to a tissue site; and
a passageway extending through said top and bottom surfaces, wherein said passageway allows ultrasound to pass from said ultrasound applicator to said tissue site. - View Dependent Claims (17, 18, 20, 21)
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19. The tissue interface receptacle of claim 19, wherein said tissue interface receptacle conforms to a surface contour of said tissue site.
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22. A tissue preparation and sensing system comprising:
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an ultrasound applicator for applying ultrasound to a tissue site;
a tissue interface receptacle, wherein said tissue interface receptacle interface is configured to couple said ultrasound applicator to said tissue site; and
an electrode, wherein said tissue interface receptacle is further configured to receive said electrode. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. An electrode device comprising:
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an electrical lead, wherein said electrical lead has a variable impedance setting; and
a biosensor. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40)
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41. A method for measuring bioelectrical signals comprising the steps of:
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applying ultrasound to a tissue site to decrease an impedance of said tissue site, placing a biosensor electrode in proximity to said tissue site, and measuring a bioelectric signal generated at said biosensor electrode. - View Dependent Claims (42, 43, 44, 45, 46, 47)
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Specification