Method of repairing primate mammalian tissue

• US 20040043009A1
• Filed: 09/03/2002
• Published: 03/04/2004
• Est. Priority Date: 09/03/2002
• Status: Abandoned Application

• Current Assignee: Regenetech, Inc.
• Original Assignee: Regenetech, Inc.
• Inventors: Rudd, Donnie
• Application Number:
  US10/233,343
• Publication Number:
  US 20040043009A1
• Time in Patent Office: Days
• US Class Current: 424/93.21
• CPC Class Codes: A61K 2035/124 the cells being hematopoietic, bone marrow derived or blood cells
• CPC Class Codes: C12N 5/0634 Cells from the blood or the immune system

Abstract

A method of repairing primate mammalian tissue is disclosed, with the method comprising removing blood cells from the primate mammal, controllably expanding the blood cells by a factor of at least seven times preferably in less than seven days while maintaining their three-dimensional geometry and their cell-to-cell support and cell-to-cell geometry, and reintroducing the expanded blood cells into the primate mammal within a time period sufficient to allow the primate mammal body system to utilize the blood cells to effectively repair damaged tissue.

Claims

1. A method of repairing primate mammalian tissue comprising removing blood cells from the primate mammal, controllably expanding the blood cells by a factor of at least seven times in less than seven days while maintaining their three-dimensional geometry and their cell-to-cell support and cell-to-cell geometry, and reintroducing the expanded blood cells into the primate mammal within a time period sufficient to allow the primate mammal body system to utilize the blood cells to effectively repair damaged tissue.

2. A method as in claim 1 wherein the expanded blood cells have any toxic material therein removed prior to reintroduction into the primate mammal body.

3. A method as in claim 1 wherein the removing of any toxic materials from the blood cells comprises removing the toxic granular content of dying cells and the toxic content of granulocytes and mycrophages.

4. A method as in claim 1 wherein the primate mammalian tissue being repaired is a vital organ.

5. A method as in claim 1 wherein the primate mammal is a human.

6. A method as in claim 1 wherein the primate mammalian tissue being repaired is heart tissue.

7. A method as in claim 1 wherein the tissue being repaired is liver tissue.

8. A method as in claim 1 wherein the tissue being repaired is hematopoietic tissue.

9. A method as in claim 1 wherein the tissue being repaired is blood vessels.

10. A method as in claim 1 wherein the tissue being repaired is skin tissue.

11. A method as in claim 1 wherein the tissue being repaired is muscle tissue.

12. A method as in claim 1 wherein the tissue being repaired is gut tissue.

13. A method as in claim 1 wherein the tissue being repaired is pancreatic tissue.

14. A method as in claim 1 wherein the tissue being repaired is central nervous system cells.

15. A method as in claim 1 wherein the tissue being repaired is bone.

16. A method as in claim 1 wherein the tissue being repaired is cartilage tissue.

17. A method as in claim 1 wherein the tissue being repaired is connective tissue.

18. A method as in claim 1 wherein the tissue being repaired is pulmonary cells.

19. A method as in claim 1 wherein the tissue being repaired is spleen tissue.

20. A method as in claim 1, which includes manipulating the blood cells to alter their curative characteristics.

21. A method as in claim 1 where in the manipulating of the blood cells includes genetically modifying the blood cells.

22. A method of replenishing primate mammalian cells comprising removing blood cells from the primate mammal, controllably expanding the blood cells while maintaining their three-dimensional geometry and their cell-to-cell support and cell-to-cell geometry, removing any toxic materials from the blood cells, and reintroducing the expanded blood cells into the primate mammal within a time period sufficient to allow the primate mammal body systems to effectively replenish different cellular populations.