Immunogen adherence inhibitor directed to lactic acid producing organisms and method of making and using it
First Claim
1. A method of production of a microbial adherence inhibitor for administration to food animals to control the incidence of acidosis in food animals by preventing the adherence of colony-forming lactic acid producing immunogens in the rumen or intestinal tracts of said food animals, which method comprises:
- a. inoculating female birds, in or about to reach their egg laying age, with a lactic acid producing immunogen;
b. allowing a period of time sufficient to permit the production in the birds of antibody to the lactic acid producing immunogen;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said eggs from the shells.
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Accused Products
Abstract
A microbial adherence inhibitor specific to lactic acid producing microorganisms, in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment or adherence of colony-forming immunogens in the rumen and intestinal tracts of host food animals. The inhibitor is made by inoculating female birds with the immunogen, allowing time for an immune response in the female bird and then harvesting the eggs that contain antibodies to the immunogen. The egg contents can be dried or used as a liquid and added to the feed or water for the host animals. Dependent upon the particular immunogen with which the female bird is inoculated, the egg antibody is used to promote the growth of food animals by improving feed conversion rates by decreasing the lactic acid production caused by the presence of certain colony-forming organisms in the animals, and to substantially reduce or eliminate the incidence of species that have been linked to very high production of lactic acid which can result in reduced performance and in acute situations, dangerously low rumen pH levels. When high levels of lactic acid are present in the rumen, rumen ulcers can form. When rumen ulcers are present other bacteria such as Fusobacterium necrophorum can escape the rumen and cause liver abscesses or laminitis, which further reduce feed conversion efficiency. Colony forming immunogens such as Streptococcus bovis (a major lactic acid producer) and Fusobacterium necrophorum can both be targeted by antibodies to enhance feed efficiency.
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Citations
42 Claims
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1. A method of production of a microbial adherence inhibitor for administration to food animals to control the incidence of acidosis in food animals by preventing the adherence of colony-forming lactic acid producing immunogens in the rumen or intestinal tracts of said food animals, which method comprises:
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a. inoculating female birds, in or about to reach their egg laying age, with a lactic acid producing immunogen;
b. allowing a period of time sufficient to permit the production in the birds of antibody to the lactic acid producing immunogen;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said eggs from the shells. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of production of a microbial adherence inhibitor for administration to food animals to control the incidence of acidosis in food animals by preventing the adherence of colony-forming lactic acid producing immunogen in the rumen or intestinal tracts of said food animals, where said immunogen is the SB antigen from Streptococcus bovis, said method comprising:
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a. inoculating female birds, in or about to reach their egg laying age, with SB antigen from Streptococcus bovis;
b. allowing a period of time to permit the production in the birds and eggs laid by the birds of antibody to SN antigen from Streptococcus bovis;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said harvested eggs from the eggshells. - View Dependent Claims (9, 10, 11, 12)
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13. A method of production of a microbial adherence inhibitor for administration to food animals to control the incidence of liver abscesses in food animals by preventing the adherence of colony-forming immunogen in the rumen or intestinal tracts of said food animals, where said immunogen is the FN antigen from Fusobactarium necrophorum, said method comprising:
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a. inoculating female birds, in or about to reach their egg laying age, with FN antigen from Fusobacterium necrophorum;
b. allowing a period of time to permit the production in the birds and eggs laid by the birds of antibody to FN antigen from Fusobacterium necrophorum;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said harvested eggs from the eggshells. - View Dependent Claims (14, 15, 16, 17)
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18. A microbial adherence inhibitor for administration to food animals to control the incidence of acidosis caused by lactic acid producing immunogen in the rumen or intestinal tracts of said food animals by reducing the ability of the immunogen to multiply, produced by the method of:
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a. inoculating female birds, in or about to reach their egg laying age, with a lactic acid producing immunogen;
b. allowing a period of time sufficient to permit the production in the birds of antibody to the lactic acid producing immunogen;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said eggs from the shells. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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25. A microbial adherence inhibitor for administration to food animals to control the incidence of acidosis caused by Streptococcus bovis immunogen in the rumen or intestinal tracts of said food animals by reducing the ability of the immunogen to multiply, produced by the method of:
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a. inoculating female birds, in or about to reach their egg laying age, with SB antigen from Streptococcus bovis;
b. allowing a period of time sufficient to permit the production in the birds and eggs laid by the birds of antibody to SB antigen from Streptococcus bovis;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said eggs from the shells. - View Dependent Claims (26, 27, 28, 29)
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30. A microbial adherence inhibitor for administration to food animals to control the incidence of liver abscesses caused by Fusobacterium necrophorum immunogen in said food animals by reducing the ability of the immunogen to multiply, produced by the method of:
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a. inoculating female birds, in or about to reach their egg laying age, with FN antigen from Fusobacterium necrophorum;
b. allowing a period of time sufficient to permit the production in the birds and eggs laid by the birds of antibody to FN antigen from Fusobacterium necrophorum;
c. harvesting the eggs laid by the birds;
d. separating the antibody-containing contents of said eggs from the shells. - View Dependent Claims (31, 32, 33, 34, 35)
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36. A method for substantially reducing or eliminating the incidence of lactic acid in food animals caused by the presence of lactic acid forming and liver abscess forming immunogens in the animal by inhibiting the ability of the immunogens to adhere to the rumen or intestinal tracts of the animal to reduce the ability of the immunogens to multiply, said method comprising:
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a. inoculating female birds, in or about to reach their egg laying age, with lactic acid producing immunogens;
b. allowing a period of time sufficient to permit the production in the birds of antibody to the lactic acid producing immunogens;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said eggs from the shells;
e. drying said separated antibody-containing contents of said eggs;
f. distributing the resulting dried egg antibody product substantially uniformly through an animal feed or water; and
g. supplying the resulting antibody-containing animal feed or water to food animals to substantially prevent adherence of the targeted immunogens to the rumen or intestinal tracts of the animals. - View Dependent Claims (37, 38, 39)
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40. A method for substantially reducing or eliminating the incidence of lactic acid in food animals caused by the presence of lactic acid forming immunogens in the animal by inhibiting the ability of the immunogens to adhere to the rumen or intestinal tracts of the animal to reduce the ability of the immunogens to multiply, said method comprising:
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a. inoculating female birds, in or about to reach their egg laying age, with lactic acid producing immunogens;
b. allowing a period of time sufficient to permit the production in the birds of antibody to the lactic acid producing immunogens;
c. harvesting the eggs laid by the birds; and
d. separating the antibody-containing contents of said eggs from the shells;
e. distributing the resulting egg mixture antibody product substantially uniformly through an animal feed or water; and
f. supplying the resulting antibody-containing animal feed or water to food animals to substantially prevent adherence of the targeted immunogens to the rumen or intestinal tracts of the animals. - View Dependent Claims (41, 42)
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Specification