Humanized antibodies that sequester Abeta peptide
First Claim
Patent Images
1. A humanized antibody, or fragment thereof, comprising:
- a. a light chain comprising three light chain complementarity determining regions (CDRs) having the following amino acid sequences;
light chain CDR1;
and a light chain framework sequence from a humanized immunoglobulin light chain; and
1
5
10
15Arg Ser Ser Gln Ser Leu Ile Tyr Ser Asp Gly Asn Ala Tyr Leu His;
or(SEQ ID NO;
1)
1
5
10
15Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Ala Tyr Leu His(SEQ ID NO;
15) light chain CDR2;
1
5Lys Val Ser Asn Arg Phe Ser and,(SEQ ID NO;
2) light chain CDR3;
1
5Ser Gln Ser Thr His Val Pro Trp Thr(SEQ ID NO;
3)
b. a heavy chain comprising three heavy chain CDRs having the following amino acid sequences;
heavy chain CDR1;
and a heavy chain framework sequence from a humanized immunoglobulin heavy chain.
1
5Arg Tyr Ser Met Ser(SEQ ID NO;
4) heavy chain CDR2;
1
5
10
15Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val Lys Gly;
or(SEQ ID NO;
5)
1
5
10
15Gln IIe Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly and,(SEQ ID NO;
16) heavy chain CDR3;
1Gly Asp Tyr(SEQ ID NO;
6)
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Abstract
A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aβ.
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Citations
45 Claims
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1. A humanized antibody, or fragment thereof, comprising:
-
a. a light chain comprising three light chain complementarity determining regions (CDRs) having the following amino acid sequences;
light chain CDR1; 1
5
10
15Arg Ser Ser Gln Ser Leu Ile Tyr Ser Asp Gly Asn Ala Tyr Leu His;
or(SEQ ID NO;
1)
1
5
10
15Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Ala Tyr Leu His (SEQ ID NO;
15)light chain CDR2;
1
5Lys Val Ser Asn Arg Phe Ser and, (SEQ ID NO;
2)light chain CDR3; 1
5Ser Gln Ser Thr His Val Pro Trp Thr (SEQ ID NO;
3)and a light chain framework sequence from a humanized immunoglobulin light chain; and
b. a heavy chain comprising three heavy chain CDRs having the following amino acid sequences;
heavy chain CDR1;
1
5Arg Tyr Ser Met Ser (SEQ ID NO;
4)heavy chain CDR2; 1
5
10
15Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val Lys Gly;
or(SEQ ID NO;
5)
1
5
10
15Gln IIe Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly and, (SEQ ID NO;
16)heavy chain CDR3;
1Gly Asp Tyr (SEQ ID NO;
6)and a heavy chain framework sequence from a humanized immunoglobulin heavy chain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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Specification