System and method for treating abnormal ventricular activation-recovery time

• US 20040044374A1
• Filed: 08/30/2002
• Published: 03/04/2004
• Est. Priority Date: 08/30/2002
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Levine, Paul A., Weinberg, Lisa P.
• Granted Patent: US 6,970,743 B2
• Time in Patent Office: Days
• US Class Current: 607/25
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

An implantable cardiac stimulation device provides long QT interval therapy for preventing abnormal ventricular activation-recovery time and ultimately ventricular arrhythmias. The device includes a sensing circuit that senses intracardiac activity of a heart and that generates electrical signals representing electrical activity of the heart. The device includes a physiologic sensor, such as body motion, or other diurnally varying sensor that reliably detects a diurnal state of the patient (i.e., not the QT interval itself). The device further includes a measuring circuit that measures a QT interval of the electrical signals, a control circuit that determines whether the QT interval is appropriate for the diurnal state, and a pulse generator that delivers pacing pulses to at least one chamber of the heart at a pacing rate when the QT Interval is pathologically too long. Furthermore, the pacing rate control circuit varies the pacing rate of the pulse generator responsive to the measured QT interval according to the measured diurnal state.

Claims

1. An implantable cardiac stimulation device, comprising:

a physiological sensor that detects a physiologic parameter associated with a diurnal state of the patient;

a QT measuring circuit that measures a QT interval based on at least one of an evoked cardiac event or an intrinsic cardiac event;

a pulse generator that delivers pacing pulses to at least one chamber of the patient'"'"'s heart at an adjustable pacing rate; and

a control circuit connected to the physiological sensor, pulse generator, and to the QT measuring circuit, wherein the control circuit is operative to process the physiological parameter to determine the diurnal state, and that is operative to determine when the measured QT interval is abnormally long for the diurnal state, and that is operative to adjust the pacing rate to shorten the QT interval to within a normal range.

2. The device of claim 1, wherein:

the control circuit maintains the pacing rate in a normal range in a closed loop manner by adjusting a pacing interval in an opposite direction of the measured QT interval.

3. The device of claim 1, wherein the control circuit increases the pacing rate when a measured QT interval exceeds a QT Threshold.

4. The device of claim 3, further comprising:

a memory circuit for storing a QT sleep threshold and a QT awake threshold; and

wherein the control circuit uses the stored QT sleep threshold as the QT Threshold when the patient is in a sleep state, and uses the QT awake threshold as the QT Threshold when the patient is in an awake state.

5. The device of claim 4, wherein the QT sleep threshold is a programmable value.

6. The device of claim 4, wherein the QT awake threshold is a programmable value.

7. The device of claim 4, wherein:

the physiologic sensor detects sleep and awake states; and

the control circuit adjusts the pacing rate to maintain the QT interval below the QT sleep threshold when the patient is detected in the sleep state, and adjusts the pacing rate to maintain the QT interval below the QT awake threshold when the patient is detected in the awake state.

8. The device of claim 4, wherein:

the control circuit updates the QT sleep threshold and the QT awake threshold based on QT intervals measured during the sleep and wake states, respectively.

9. The device of claim 8, wherein:

the control circuit updates the QT sleep and QT awake thresholds based on an average of the QT intervals measured during the sleep and wake states, respectively.

10. The device of claim 1, wherein:

the control circuit verifies that capture is maintained in at least one ventricle before assessing whether the QT interval is abnormally long.

11. The device of claim 10, wherein:

the control circuit verifies that capture is maintained in both ventricles before assessing whether the QT interval is abnormally long.

12. The device of claim 1, wherein:

the control circuit verifies that V-V timing is optimized before assessing whether the QT interval is abnormally long.

13. The device of claim 1, wherein the QT interval is a QT interval of one of the ventricles.

14. The device of claim 1, wherein the QT interval is a stim-T interval of one of the ventricles.

15. The device of claim 1, wherein the QT interval is a J-T interval of one of the ventricles.

16. The device of claim 1, wherein the QT interval is the difference between a QT interval of one of the ventricles of the heart and a corresponding QT interval of the other one of the ventricles of the heart.

17. The device of claim 1, wherein the QT interval is the difference between a stim-T interval of one of the ventricles of the heart and a corresponding stim-T interval of the other one of the ventricles of the heart.

18. The device of claim 1, wherein the QT interval is the difference between a J-T interval of one of the ventricles of the heart and a corresponding J-T interval of the other one of the ventricles of the heart.

19. The device of claim 1, wherein the pulse generator is configured to deliver pacing pulses to one of the ventricles of the heart.

20. The device of claim 1, wherein the pulse generator is configured to deliver pacing pulses to both ventricles of the heart.

21. The device of claim 1, wherein the pulse generator is configured to deliver pacing pulses to an atrium of the heart.

22. The device of claim 3, wherein the control circuit maintains the pacing rate at an increased rate for a period of time after the QT interval falls below the QT Threshold.

23. The device of claim 1, further comprising:

a memory that stores the diagnostic data; and

wherein the control circuit triggers the storage of measured QT interval diagnostic data into the memory.

24. The device of claim 23, wherein the diagnostic data comprises a histogram data.

25. The device of claim 24, wherein the histogram data comprises at least one of QT interval histogram data, stim-T interval histogram data and J-T interval histogram data.

26. The device of claim 23, wherein the diagnostic data comprises time stamping so that a QT interval may be plotted over time.

27. The device of claim 23, wherein the diagnostic data comprises storing changes in the V_Right-V_Left Delay.

28. The device of claim 27, wherein the diagnostic data comprises storing a sudden change in the V_Right-V_Left Delay.

29. The device of claim 27, wherein the diagnostic data comprises storing a gradual change in the V_Right-V_Left Delay.

30. The device of claim 23, wherein the diagnostic data comprises storing a sequence of activation between the patient'"'"'s left and right cardiac depolarizations.

31. The device of claim 30, wherein the diagnostic data comprises storing a change in the sequence of activation.

32. The device of claim 23, wherein the diagnostic data comprises storing Right QT Interval and the Left QT interval.

33. The device of claim 23, wherein the diagnostic data comprises storing an amplitude of the Left T-wave compared to the Right T-wave.

34. The device of claim 23, wherein the diagnostic data comprises periodically storing measurements for the QT interval less frequently during periods of sleep.

35. The device of claim 23, wherein the diagnostic data comprises periodically storing measurements for the QT interval more frequently during known periods of higher incidence of SCD.

36. The device of claim 23, wherein the diagnostic data comprises periodically storing measurements for the QT interval more frequently during a brief awakening period which immediately follows the sleep state.

37. The device of claim 23, wherein the diagnostic data comprises periodically storing measurements for the QT interval at periodic intervals during the day corresponding to the awake state with an appropriate frequency to track drug changes.

38. The device of claim 1, wherein the physiologic sensor the physiologic sensor detects a physiologic parameter of the patient'"'"'s body that changes during at least sleep and awake states of the patient.

39. The device of claim 38, wherein the physiologic sensor is a body motion sensor.

40. The device of claim 38, wherein the physiologic sensor is a minute ventilation sensor.

41. The device of claim 38, wherein the physiologic sensor is a temperature sensor.

42. The device of claim 38, wherein the physiologic sensor is a oxygen saturation sensor.

43. The device of claim 38, wherein the physiologic sensor is a blood flow sensor.

44. The device of claim 38, wherein the physiologic sensor is a cardiac output sensor.

45. The device of claim 38, wherein the physiologic sensor is a pH sensor.

46. The device of claim 38, wherein the physiologic sensor is a rate detector that detects the patient'"'"'s sinus rate.

47. The device of claim 38, wherein the physiologic sensor is an electrogram integrator that integrates an evoked response to produce a paced depolarization integral.

48. The device of claim 38, wherein the physiologic sensor is processed to determine the variance of the physiologic parameter of the patient, wherein a low variance indicates a sleep state and a high variance indicates an awake state.

49. An implantable cardiac stimulation device for treating abnormal ventricular activation-recovery time, comprising:

means for detecting a patient'"'"'s diurnal state including at least a sleep and an awake state;

means for measuring QT intervals based on at least one of an evoked cardiac event or an intrinsic cardiac event;

pulse generating means for generating pacing pulses to control a pacing interval of the pacing pulses; and

control means, in response to the measuring means, for adjusting the pacing interval by an amount that sufficiently shortens the QT interval to maintain the QT interval to within a normal range for the detected diurnal state.

50. The device of claim 49, wherein:

the control means further provides closed loop control by adjusting the pacing interval in an opposite direction of the measured QT interval.

51. The device of claim 49, wherein the control means varies the pacing interval when a measured QT interval exceeds a QT Threshold.

52. The device of claim 51, further comprising:

means for using a QT sleep threshold as the QT Threshold when the patient is in a sleep state; and

means for using a QT awake threshold as the QT Threshold when the patient is in a sleep state.

53. The device of claim 52, further comprising:

means for storing the QT sleep threshold and the QT awake threshold based on the patient'"'"'s QT intervals measured during the sleep and wake states, respectively.

54. The device of claim 49, further comprising:

means for verifying that capture is maintained in at least one ventricle before assessing whether the QT interval is abnormally long.

55. The device of claim 49, further comprising:

means for verifying that capture is maintained in both ventricles before assessing whether the QT interval is abnormally long.

56. The device of claim 49, further comprising:

means for verifying that V-V timing is optimized before assessing whether the QT interval is abnormally long.

57. A method for treating abnormal ventricular activation-recovery time using an implantable cardiac stimulation device, comprising:

detecting a diurnally varying parameter of the patient;

correlating the patient'"'"'s diurnally varying parameter to an activity state including at least a sleep and an awake state;

measuring QT intervals based on at least one of an evoked cardiac event or an intrinsic cardiac event during the sleep and awake states;

generating pacing pulses to control a pacing interval of the pacing pulses; and

adjusting the pacing interval by an amount that sufficiently shortens the QT interval to maintain the QT interval to within a normal range for the detected activity state.

58. The method of claim 57, wherein the adjusting step comprises:

controlling the pacing interval in a closed loop manner by adjusting the pacing interval in an opposite direction of the measured QT interval.

59. The method of claim 57, wherein the adjusting step comprise:

shortening the pacing interval when a measured QT interval exceeds a QT Threshold.

60. The method of claim 59, further comprising:

defining a QT sleep threshold as the QT Threshold when the patient is in a sleep state; and

defining a QT awake threshold as the QT Threshold when the patient is in a sleep state.

61. The method of claim 60, further comprising:

learning the QT sleep threshold and the QT awake threshold based on the patient'"'"'s QT intervals measured during the sleep and wake states, respectively; and

updating the QT sleep threshold and the QT awake threshold in a memory.

62. The method of claim 57, further comprising:

verifying that capture is maintained in at least one ventricle before assessing whether the QT interval is abnormally long.

63. The method of claim 62, further comprising:

verifying that capture is maintained in both ventricles before assessing whether the QT interval is abnormally long.

64. The method of claim 57, further comprising:

verifying that V-V timing is optimized before assessing whether the QT interval is abnormally long.