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Animal model for toxicology and dose prediction

  • US 20040045045A1
  • Filed: 05/30/2003
  • Published: 03/04/2004
  • Est. Priority Date: 05/30/2002
  • Status: Abandoned Application
First Claim
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1. A method for generating a non-human vertebrate animal model having target normal tissue of mature phenotype and target diseased tissues both from a first vertebrate animal, comprising the steps of:

  • (a) implanting immature target normal tissue or normal tissue recombinants made from immature or progenitor cells of the first animal into a second, non-human vertebrate recipient animal at a location sufficient to support growth and maturation of said tissue;

    (b) allowing the target normal tissue of the first animal to develop into a tissue with a mature phenotype;

    (c) implanting target diseased tissue or diseased cells of the first animal into a non-human vertebrate recipient animal at a location sufficient to support growth of the diseased tissue; and

    (d) allowing the target diseased tissue or diseased cells from the first animal to grow.

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