Multi-analyte reference solutions with stable pO2 in zero headspace containers
First Claim
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1. A zero headspace container that maintains a stable partial pressure of oxygen in a multi-analyte reference solution housed therein, comprising:
- (a) an inner layer forming the interior of the container and composed of a polymeric material that does not react with oxygen or has an oxygen reactivity that is sufficiently low so as to maintain the partial pressure of oxygen of a multi-analyte reference solution therein at a specified value ±
4 mm Hg;
(b) an intermediate layer comprised of aluminum;
(c) an outer layer that serves to protect the intermediate layer from physical damage; and
(d) a multi-analyte reference solution housed within the interior of the container.
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Abstract
Multi-analyte reference solutions having a stable partial pressure of oxygen (pO2) in zero headspace packaging and methods for preparing such solutions are disclosed. The solutions have long shelf and use lives when stored at room temperature and are packaged in laminated foil containers having low or no oxygen reactivity. Access devices are also disclosed.
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Citations
31 Claims
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1. A zero headspace container that maintains a stable partial pressure of oxygen in a multi-analyte reference solution housed therein, comprising:
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(a) an inner layer forming the interior of the container and composed of a polymeric material that does not react with oxygen or has an oxygen reactivity that is sufficiently low so as to maintain the partial pressure of oxygen of a multi-analyte reference solution therein at a specified value ±
4 mm Hg;
(b) an intermediate layer comprised of aluminum;
(c) an outer layer that serves to protect the intermediate layer from physical damage; and
(d) a multi-analyte reference solution housed within the interior of the container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A zero headspace container that maintains a stable partial pressure of oxygen in a multi-analyte reference solution housed therein, comprising:
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(a) an inner layer forming the interior of the container and comprised of a polymer;
(b) an intermediate layer comprised of aluminum;
(c) an outer layer that serves to protect the intermediate layer from physical damage; and
(d) a multi-analyte reference solution housed within the interior of the container, wherein the inner layer and the multi-analyte reference solution are free from any component having an oxygen reactivity that is sufficiently destabilizing so as to allow the partial pressure of oxygen of the multi-analyte reference solution to deviate from a specified value by at least 4 mm Hg.
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21. A method for maintaining a stable partial pressure of oxygen in a multi-analyte reference solution, the method comprising:
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(a) introducing the reference solution into a laminated container comprising (i) an inner layer that serves as the interior of the container and is composed of a polymeric material that does not react with oxygen or has an oxygen reactivity that is sufficiently low so as to maintain the partial pressure of oxygen of the reference solution at a specified value ±
4 mm Hg, (ii) an intermediate layer of aluminum, and (iii) an outer layer that serves to protect the intermediate layer from physical damage, and(b) sealing the container so as to provide zero headspace therein. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for maintaining a stable partial pressure of oxygen in a multi-analyte reference solution, the method comprising:
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(a) introducing the reference solution into a laminated container comprising (i) an inner layer that serves as the interior of the container and is comprised of a polymer, (ii) an intermediate layer of aluminum, and (iii) an outer layer that serves to protect the intermediate layer from physical damage, wherein the inner layer and the reference solution are free from any component having an oxygen reactivity that is sufficiently high so as to allow the partial pressure of oxygen of the multi-analyte reference solution to deviate from a specified value by at least 4 mm Hg; and
(b) sealing the container so as to provide zero headspace therein.
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Specification