Filler composition for soft tissue augmentation and reconstructive surgery
First Claim
1. A filler composition for soft-tissue augmentation and reconstructive surgery comprising an injectable thermoforming solution comprising:
- a) 0.1 to 5.0% by weight of chitosan or collagen or a derivative thereof; and
b) 1.0 to 20% by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar;
wherein said solution is stable and turns into a solid gel within a temperature range from 20 to 70°
C., said gel having a acceptable consistency for providing a mechanical support or a volume or thickness increase to surrounding soft tissues once injected therein.
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Abstract
The present invention relates to a filler composition for soft-tissue augmentation and reconstructive surgery comprising an effective amount of an injectable thermo-gelling solution comprising 0.1 to 5.0% by weight of chitosan or collagen or a derivative thereof; and 1.0 to 20% by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar. The solution is stable and turns into a gel within a tem-perature range from 20 to 70° C. The gel has a cosmetically acceptable consistency for providing a mechanical support to surrounding soft tissues once injected therein. The composition can thus be used as filler for soft tissue augmentation and reconstructive surgery.
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Citations
43 Claims
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1. A filler composition for soft-tissue augmentation and reconstructive surgery comprising an injectable thermoforming solution comprising:
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a) 0.1 to 5.0% by weight of chitosan or collagen or a derivative thereof; and
b) 1.0 to 20% by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar;
wherein said solution is stable and turns into a solid gel within a temperature range from 20 to 70°
C., said gel having a acceptable consistency for providing a mechanical support or a volume or thickness increase to surrounding soft tissues once injected therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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- 25. A filler composition for soft-tissue augmentation and reconstructive surgery comprising an injectable thermo-forming solution comprising at least one fatty acid.
Specification