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Colloidal suspension of submicronic particles for carrying hydrophilic active principles (insulin) and method for preparing same

  • US 20040048782A1
  • Filed: 04/01/2003
  • Published: 03/11/2004
  • Est. Priority Date: 10/06/2000
  • Status: Abandoned Application
First Claim
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1. Colloidal suspension of submicron particles capable of being used especially for carrying one or more active principles (AP), these particles being individualized supramolecular arrangements that are:

  • based on an amphiphilic copolymer comprising;

    at least one block of hydrophobic linear polyamino acid(s) (PAA) having α

    -peptide linkages, the hydrophobic amino acids, AAO, constituting this PAA block being identical to or different from one another;

    and at least one block of hydrophilic polymer(s) of the polyalkylene glycol (PAG) type, preferably of the polyethylene glycol (PEG) type;

    and capable of associating with at least one AP in colloidal suspension, in the undissolved state, and releasing it, especially in vivo, in a prolonged and/or delayed manner, characterized in that the particles it contains are associated and/or can be associated with at least one AP selected from hydrophilic AP, preferably proteins, this AP consisting particularly preferably of insulin.

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