Nicotine and/or nicotine agonists for the treatment of general anesthetic effects and side effects
First Claim
1. A method for reducing hyperalgesia following a pain-inducing procedure being performed on a subject which comprises:
- (a) administering to the subject an anesthetic which is an antagonist of the subject'"'"'s nicotinic acetylcholine receptor, in an amount effective to inhibit the subject'"'"'s perception of pain during the pain-inducing procedure;
(b) then performing the pain-inducing procedure on the subject; and
(c) administering to the subject a hyperalgesia-reducing amount of an agonist of the subject'"'"'s nicotinic acetylcholine receptor such that the subject'"'"'s hyperalgesia following the procedure is reduced.
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Accused Products
Abstract
This invention provides a method for reducing hyperalgesia following a pain-inducing procedure being performed on a subject which comprises administering to the subject an anesthetic which is an antagonist of the subject'"'"'s nicotinic acetylcholine receptor, in an amount effective to inhibit the subject'"'"'s perception of pain during the pain-inducing procedure; then performing the pain-inducing procedure on the subject; and administering to the subject a hyperalgesia-reducing amount of an agonist of the subject'"'"'s nicotinic acetylcholine receptor such that the subject'"'"'s hyperalgesia following the procedure is reduced. This invention also provides related methods and articles of manufacture.
51 Citations
50 Claims
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1. A method for reducing hyperalgesia following a pain-inducing procedure being performed on a subject which comprises:
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(a) administering to the subject an anesthetic which is an antagonist of the subject'"'"'s nicotinic acetylcholine receptor, in an amount effective to inhibit the subject'"'"'s perception of pain during the pain-inducing procedure;
(b) then performing the pain-inducing procedure on the subject; and
(c) administering to the subject a hyperalgesia-reducing amount of an agonist of the subject'"'"'s nicotinic acetylcholine receptor such that the subject'"'"'s hyperalgesia following the procedure is reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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- 47. An article of manufacture comprising a packaging material having therein a nicotinic acetylcholine receptor agonist and a label indicating a use of the agonist for reducing hyperalgesia in a subject having therein a hyperalgesia-inducing amount of an anesthetic that acts as a nicotinic acetylcholine receptor antagonist.
- 49. An article of manufacture comprising a packaging material having therein a nicotinic acetylcholine receptor agonist and a label indicating a use of the agonist for reducing enhanced pain sensitivity in a subject following surgery on the subject, which surgery employs an anesthetic that acts as a nicotinic acetylcholine receptor antagonist.
Specification