Apparatus and method for determining responders to cardiac resynchronization therapy using implantable accelerometers
First Claim
1. A device for measuring a synchronicity of contraction of a heart to determine if an individual would be a responder to cardiac resynchronization therapy, the device comprising:
- a first electrode positioned at a first ventricular wall location and configured to mechanically measure movement of the first ventricular wall location;
a second electrode positioned at a second ventricular wall location and configured to mechanically measure movement of the second ventricular wall location;
a processing module coupled to the first and second electrodes, the processing module adapted to process a first signal produced by the first electrode at the first ventricular wall location and a second signal produced by the second electrode at the second ventricular wall location and generate an output based on the processed signals; and
a comparator module coupled to the processing module to indicate that the individual would be a responder if the output of the processing module exceeds a threshold and to indicate that the individual would be a non-responder if the output of the processing module is below the threshold.
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Abstract
A device for measuring a synchronicity of contraction of a heart to determine if an individual would be a responder to cardiac resynchronization therapy. The device may include a first electrode positioned at a first ventricular wall location to measure movement of the first ventricular wall location and generate a first signal, as well as a second electrode positioned at a second ventricular wall location to measure movement of the second ventricular wall location and generate a second signal. A processing module may process the first and second signals, for example, integrate the signals multiple times, and generate an output based on the processed signals. Based on this output, an individual can be labeled a responder or non-responder to cardiac resynchronization therapy. The electrodes may each include an accelerometer to measure acceleration of the heart wall.
23 Citations
18 Claims
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1. A device for measuring a synchronicity of contraction of a heart to determine if an individual would be a responder to cardiac resynchronization therapy, the device comprising:
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a first electrode positioned at a first ventricular wall location and configured to mechanically measure movement of the first ventricular wall location;
a second electrode positioned at a second ventricular wall location and configured to mechanically measure movement of the second ventricular wall location;
a processing module coupled to the first and second electrodes, the processing module adapted to process a first signal produced by the first electrode at the first ventricular wall location and a second signal produced by the second electrode at the second ventricular wall location and generate an output based on the processed signals; and
a comparator module coupled to the processing module to indicate that the individual would be a responder if the output of the processing module exceeds a threshold and to indicate that the individual would be a non-responder if the output of the processing module is below the threshold. - View Dependent Claims (2, 3)
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4. A device for determining whether an individual would be a responder to cardiac resynchronization therapy, the device comprising:
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a first accelerometer positioned at a first ventricular wall location;
a second accelerometer positioned at a second ventricular wall location;
a processing module coupled to the first and second accelerometers, the processing module adapted to process a first signal produced by acceleration of the first accelerometer at the first ventricular wall location and a second signal produced by acceleration of the second accelerometer at the second ventricular wall location and generate an output; and
a comparator module coupled to the processing module to indicate that the individual would be a responder if the output of the processing module exceeds a threshold and to indicate that the individual would be a non-responder if the output of the processing module is below the threshold. - View Dependent Claims (5, 6, 7)
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8. A cardiac resynchronization system comprising:
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a cardiac resynchronization device coupled to a heart of an individual to provide cardiac resynchronization therapy; and
a device coupled to the cardiac resynchronization device, the device including;
a first accelerometer positioned at a first ventricular wall location;
a second accelerometer positioned at a second ventricular wall location;
a processing module coupled to the first and second accelerometers, the processing module adapted to process a first signal produced by acceleration of the first accelerometer at the first ventricular wall location and a second signal produced by acceleration of the second accelerometer at the second ventricular wall location and generate an output; and
a comparator module coupled to the processing module to indicate that the individual would be a responder if the output of the processing module exceeds a threshold and to indicate that the individual would be a non-responder if the output of the processing module is below the threshold. - View Dependent Claims (9, 10, 11, 12)
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13. A method for determining whether an individual would be a responder to cardiac resynchronization therapy, the method comprising steps of:
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sensing acceleration with a first accelerometer located at a first location on the individual'"'"'s heart to produce a first signal;
sensing acceleration with a second accelerometer located at a second location on the heart to produce a second signal;
processing the first signal and the second signal to create a synchronicity index that measures a phase difference of contraction at the first and second locations; and
comparing the synchronicity index to a threshold to determine whether an individual would be a responder. - View Dependent Claims (14, 15)
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16. A device for determining whether an individual'"'"'s heart would be a responder to cardiac resynchronization therapy, the device comprising:
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a first accelerometer means for measuring acceleration of the heart at a first ventricular wall location and for producing a first signal;
a second accelerometer means for measuring acceleration of the heart at a second ventricular wall location and for producing a second signal;
a processing means for processing the first signal and the second signal and generating an output; and
a comparator means for indicating whether the individual would be a responder or a non-responder based on the output from the processing means. - View Dependent Claims (17)
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18. A computer-readable medium having computer-executable modules comprising:
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a processing module adapted to process a first signal produced by acceleration of a first accelerometer at a first ventricular wall location and a second signal produced by acceleration of a second accelerometer at the second ventricular wall location and generate an output; and
a comparator module coupled to the processing module to generate a signal indicating that the individual would be a responder if the output of the processing module exceeds a threshold and indicating that the individual would be a non-responder if the output of the processing module is below the threshold.
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Specification