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Methods and systems for assessing biological materials using optical and spectroscopic detection techniques

  • US 20040052730A1
  • Filed: 06/03/2003
  • Published: 03/18/2004
  • Est. Priority Date: 10/04/1995
  • Status: Abandoned Application
First Claim
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1. A method for in vivo screening a candidate compound for activity as a diagnostic or therapeutic agent, comprising:

  • introducing a candidate compound to a sample of biological material in a subject;

    acquiring at least two test data sets corresponding to one or more optical properties of at least one spatial location in the sample, wherein each test data set is acquired at different times over a time period;

    creating at least one test map of the magnitude of at least some of the test data sets;

    comparing the test map to a comparison map, wherein the comparison map corresponds to the magnitudes of one or more optical properties of a comparison sample having a predetermined physiological condition; and

    assessing the activity of the candidate compound as a diagnostic or therapeutic agent based on the comparison between the test map and the comparison map.

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