Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
First Claim
1. A pharmaceutical composition comprising an agent or agents having (i) at least one receptor tyrosine kinase blocking specificity and (ii) at least one angiogenesis inhibiting specificity, wherein said agent or agents is/are not a cytokine immunoconjugate, optionally together with a pharmaceutically acceptable carrier, diluent or recipient.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of receptor tyrosine kinase antagonists/inhibitors, especially ErbB receptor antagonists, more preferably EGF receptor (Her 1) antagonists and anti-angiogenic agents, preferably integrin antagonists, optionally together with agents or therapy forms that have additive or synergistic efficacy when administered together with said combination of antagonists/inhibitors, such as chemotherapeutic agents and or radiation therapy. The therapy can result in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone.
-
Citations
42 Claims
-
1. A pharmaceutical composition comprising an agent or agents having
(i) at least one receptor tyrosine kinase blocking specificity and (ii) at least one angiogenesis inhibiting specificity, wherein said agent or agents is/are not a cytokine immunoconjugate, optionally together with a pharmaceutically acceptable carrier, diluent or recipient.
-
22. A pharmaceutical kit comprising
(i) a package comprising at least one ErbB receptor blocking agent, and (ii) a package comprising at least one angiogenesis inhibiting agent.
-
24. A pharmaceutical kit comprising
(i) a package comprising at least one ErbB receptor blocking agent and at least one angiogenesis inhibiting agent, and (ii) a package comprising a cytotoxic agent.
-
35. A method for treating tumors or tumor metastases in a patient comprising administering to said patient a therapeutically effective amount of an agent or agents having
(i) at least one receptor tyrosine kinase blocking specificity and (ii) at least one angiogenesis inhibiting specificity, wherein said agent or agents is/are not a cytokine immunoconjugate.
Specification