Microparticle coated medical device
First Claim
1. A drug-loaded microparticle formulation method comprising:
- providing a first solution including an amount of a chemical dissolved in a volume of water;
adding a volume of a water soluble drug into said first solution, to form a second solution;
combining a volume of a curing agent solution with a volume of said second solution to form a final solution; and
adding a volume of said final solution into an oil bath forming one or more droplets suspended in said bath.
1 Assignment
0 Petitions
Accused Products
Abstract
A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals/solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.
-
Citations
24 Claims
-
1. A drug-loaded microparticle formulation method comprising:
-
providing a first solution including an amount of a chemical dissolved in a volume of water;
adding a volume of a water soluble drug into said first solution, to form a second solution;
combining a volume of a curing agent solution with a volume of said second solution to form a final solution; and
adding a volume of said final solution into an oil bath forming one or more droplets suspended in said bath. - View Dependent Claims (2, 3, 4, 5)
-
-
6. A drug-loaded microparticle formulation method comprising:
-
providing a first solution including an amount of material dissolved in a volume of solvent;
adding a volume of a water soluble drug into said first solution to form a mixture;
combining a volume of a second solution with a volume of said mixture to form a final solution; and
evaporating a solvent from said final solution to form one or more microparticles. - View Dependent Claims (7, 8, 9, 10)
-
-
11. A method of applying one or more microparticles to a medical device comprising:
-
providing a polymer solution;
combining one or more microparticles in said polymer solution to form a suspension;
applying said suspension to a surface of said medical device; and
centrifuging said medical device. - View Dependent Claims (12, 13, 14, 15, 16)
-
- 17. A drug loaded medical device comprising a first polymer matrix coated on a surface of said device, said first polymer matrix including one or more microparticles suspended in a polymer solution, each of said microparticles having one or more drugs loaded within said microparticle.
Specification