Substituted pyrrolines as kinase inhibitors
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Abstract
The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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Citations
57 Claims
- 1. A compound of Formula (I):
- 36. The method of claim 36 wherein the disorder is mediated by selective inhibition of a kinase selected from protein kinase C or glycogen synthase kinase-3.
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37. The method of claim 37 wherein the kinase is selected from protein kinase C α
- , protein kinase C β
-II, protein kinase C γ
or glycogen synthase kinase-3β
.
- , protein kinase C β
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39. The method of claim 39 wherein at least two kinases are selected from protein kinase C α
- , protein kinase C β
-II, protein kinase C γ
or glycogen synthase kinase-3β
.
- , protein kinase C β
- 42. The method of claim 42 wherein cardiovascular diseases are selected from acute stroke, heart failure, cardiovascular ischemia, thrombosis, atherosclerosis, hypertension, restenosis, retinopathy of prematurity or age-related macular degeneration.
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53. A method of treating or ameliorating a disorder selected from diabetes-associated disorders, dermatological disorders, oncological disorders or central nervous system disorders comprising administering to a subject in need of treatment a therapeutically effective amount of a compound of Formula (I):
- 55. The method of claim 55 wherein dermatological disorders are selected from the group consisting of psoriasis, hair loss and baldness.
Specification