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Epimerization of analogs of vitamin D

  • US 20040054204A1
  • Filed: 06/11/2003
  • Published: 03/18/2004
  • Est. Priority Date: 06/13/2002
  • Status: Active Grant
First Claim
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1. A method of epimerizing a C-24 epimer of a vitamin D analog having a hydroxyl substituent on an asymmetric allylic carbon at the 24 position comprising the steps of:

  • a) esterifying the hydroxyl group on the asymetric allylic carbon atom at the 24 position with an esterifying agent, b) contacting>

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    a solution of the ester in a solvent with an epimerization-active solid, whereby the ester is epimerized, and c) hydrolyzing the epimerized ester to obtain a mixture of C-24 epimers having a hydroxyl substituent on the asymmetric allylic carbon at position 24

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