Psychological stress in humans

• US 20040054265A1
• Filed: 09/11/2003
• Published: 03/18/2004
• Est. Priority Date: 09/13/2002
• Status: Abandoned Application

• Current Assignee: Conopco (Unilever PLC)
• Original Assignee: Conopco (Unilever PLC)
• Inventors: Cobain, Mark Robert, Talbot, Duncan Charles Stuart, Powell, Jonathan Richard
• Application Number:
  US10/660,125
• Publication Number:
  US 20040054265A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: G01N 33/88 involving prostaglandins or their receptors

Abstract

The present invention relates to the field of psychological stress in humans, more particularly the invention relates to the diagnosis of human psychological stress through the use of isoprostanes as a biological marker.

Claims

1. A method of determining a pyschological stress level in a human, the method comprising with measurement means, measuring the level of one or more isoprostanes in a biological sample derived from the human and calculating the psychological stress level from said measured isoprostane level.

2. The method of claim 1, wherein said measuring means comprises means for measuring the level of one or more antibodies and/or antibody fragments directed thereto.

3. The method of claim 1, wherein said biological sample comprises one or more body fluids.

4. The method of claim 3, wherein the one or more fluids is or are selected from the group consisting of urine, blood, tears, sweat and saliva.

5. The method of claim 4, wherein said psychological stress is associated with one or more conditions selected from the group comprising clinical depression, post traumatic stress disorder, chronic fatigue syndrome and ME.

6. The method of claim 4, wherein said one or more isoprostanes when measured in urine comprises 2,3-dinor-8-iso-prostaglandin F_1α

and/or a racemic diastereoisomer thereof.

7. The method of claim 1, wherein said one or more isoprostane is an F2-isoprostane.

8. The method of claim 1, wherein said one or more isoprostane is a 8-F₂-IsoP and/or a racemic diastereoisomer thereof.