Vascular prosthesis and method for production thereof
First Claim
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1. A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein said first layer and said second layer are each made of first and second electrospun polymer fibers.
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Abstract
A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each made of first and second electrospun polymer fibers.
191 Citations
164 Claims
- 1. A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein said first layer and said second layer are each made of first and second electrospun polymer fibers.
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29. A method of producing a vascular prosthesis, the method comprising:
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electrospinning a first liquefied polymer onto a precipitation electrode hence providing a first layer having a predetermined first porosity; and
electrospinning a second liquefied polymer onto said precipitation electrode hence providing a second layer having a predetermined second porosity. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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72. A vascular prosthesis made of at least one biocompatible material, the vascular prosthesis having at least two characteristics selected from the group consisting of:
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(a) having an inner diameter expandable by at least 10% under a pulsatile pressure characterizing a mammalian blood system;
(b) capable of maintaining said inner diameter while bent at a bent diameter of twice said inner diameter;
(c) having a porosity of at least 60%;
(d) preventing leakage of blood passing therethrough;
(e) characterized by tissue ingrowth and cell endothelization endothelization over at least 90% of the vascular prosthesis within at least 10 days from implantation in a mammal; and
(f) having a self-sealing properties so as to minimize blood leakage following piercing. - View Dependent Claims (73, 74, 136)
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75. A method of replacing a portion of a blood vessel, comprising:
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providing a vascular prosthesis which comprises a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein said first layer and said second layer are each made of first electrospun polymer fibers;
excising the portion of the blood vessel, thereby creating a pair of blood vessel ends; and
connecting said vascular prosthesis to said pair of blood vessel ends so as to allow blood flow through said vascular prosthesis. - View Dependent Claims (76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104)
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105. A method of bypassing an obstructed portion of a blood vessel, comprising:
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providing a vascular prosthesis which comprises a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein said first layer and said second layer are each made of first electrospun polymer fibers;
forming a pair of holes in the blood vessel upstream and downstream the obstruction; and
connecting said vascular prosthesis to said pair of holes so as to allow blood flow through said vascular prosthesis. - View Dependent Claims (106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134)
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135. A method of connecting a pair of blood vessels, comprising:
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providing a vascular prosthesis which comprises a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein said first layer and said second layer are each made of first electrospun polymer fibers;
forming a pair of holes in the pair of blood vessels; and
connecting said vascular prosthesis to said pair of holes so as to allow blood flow through said vascular prosthesis, thereby connecting the pair of blood vessels. - View Dependent Claims (137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164)
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Specification