Drug diffusion coatings, applications and methods
First Claim
1. A biocompatible coating composition for therapeutic agent diffusion in vivo comprising:
- a layer comprising a therapeutic agent dispersed in a polymeric matrix; and
a membrane posited over the layer, the membrane formed from the plasma polymerization of hydrocyclosiloxane monomer of the general formula;
where R is an aliphatic group having 1 to about 5 carbon atoms and n is an integer from 2 to about 10, and wherein the membrane cross-links with the polymeric matrix of the layer.
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Accused Products
Abstract
Methods, coatings and coated medical devices are provided, wherein a plasma-deposited aliphatic polymerized hydrocyclosiloxane membrane is deposited as a diffusion control barrier for a drug deliver component consisting of one or more therapeutic agents coated on a surface or contained within a matrix, preferably a polymeric matrix, coated on a surface. The plasma-polymerized hydrocyclosiloxane membrane coats all or substantially all of the drug delivery component in contact or communication with the exterior surface, such that all or substantially all of any drug or therapeutic agent must diffuse across the membrane in order to be released.
41 Citations
42 Claims
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1. A biocompatible coating composition for therapeutic agent diffusion in vivo comprising:
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a layer comprising a therapeutic agent dispersed in a polymeric matrix; and
a membrane posited over the layer, the membrane formed from the plasma polymerization of hydrocyclosiloxane monomer of the general formula;
where R is an aliphatic group having 1 to about 5 carbon atoms and n is an integer from 2 to about 10, and wherein the membrane cross-links with the polymeric matrix of the layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 18, 19)
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11. A biocompatible coating composition for therapeutic agent diffusion in vivo comprising:
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a layer comprising a therapeutic agent; and
a membrane posited over the layer, the membrane formed from the plasma polymerization of hydrocyclosiloxane monomer of the general formula;
where R is an aliphatic group having 1 to about 5 carbon atoms and n is an integer from 2 to about 10, and wherein the membrane cross-links with at least a portion of the therapeutic agent of the layer. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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20. An implantable medical device comprising:
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a structural component adapted for implantation in a patient, the structural component comprising at least one exterior surface;
a layer comprising a therapeutic agent posited over at least a portion of the at least one exterior surface; and
a membrane posited over the layer, the membrane formed from the plasma polymerization of hydrocyclosiloxane monomer of the general formula;
where R is an aliphatic group having 1 to about 5 carbon atoms and n is an integer from 2 to about 10. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of applying a biocompatible coating composition to a structural component for therapeutic agent diffusion in vivo comprising:
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providing a structural component adapted for introduction into a patient, the structural component comprising at least one exterior surface;
positing a layer comprising a therapeutic agent over at least a portion of the at least one exterior surface; and
plasma depositing a membrane over the layer comprising a therapeutic agent, the membrane formed from the plasma polymerization of hydrocyclosiloxane monomer of the general formula;
where R is an aliphatic group having 1 to about 5 carbon atoms and n is an integer from 2 to about 10. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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Specification