Reactor systems having a light-interacting component
First Claim
1. An apparatus, comprising:
- a chip comprising a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
at least one waveguide in optical communication with the predetermined reaction site.
1 Assignment
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Accused Products
Abstract
Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.
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Citations
96 Claims
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1. An apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
at least one waveguide in optical communication with the predetermined reaction site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A apparatus, comprising:
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a chip comprising a predetermined reaction site having at least one substantially hydrophobic surface and a volume of less than about 1 ml; and
at least one waveguide in optical communication with the predetermined reaction site.
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43. A apparatus, comprising:
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a chip comprising a predetermined reaction site having at least one substantially hydrophilic surface and a volume of less than about 1 ml; and
at least one waveguide in optical communication with the predetermined reaction site.
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44. A apparatus, comprising:
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a chip comprising a predetermined reaction site having at least one substantially cytophilic surface and a volume of less than about 1 ml; and
at least one waveguide in optical communication with the predetermined reaction site.
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45. A apparatus, comprising:
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a chip comprising a predetermined reaction site having at least one substantially cytophobic surface and a volume of less than about 1 ml; and
at least one waveguide in optical communication with the predetermined reaction site.
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46. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml; and
a milled waveguide in optical communication with the predetermined reaction site.
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47. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml; and
a machined waveguide in optical communication with the predetermined reaction site.
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48. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
an optical element in optical communication with the predetermined reaction site. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
a photodetector in optical communication with the predetermined reaction site. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66)
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67. A method, comprising:
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providing a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site;
providing material in the predetermined reaction site, the material having a smallest dimension;
directing electromagnetic radiation having an average beam diameter less than the smallest dimension of the material;
allowing the electromagnetic radiation to interact with the material to produce altered radiation; and
determining the altered radiation. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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78. A method, comprising:
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providing a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
optically causing a biological change in a biological material located at the predetermined reaction site. - View Dependent Claims (79, 80, 81, 82)
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83. A apparatus, comprising:
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a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
a source of light in optical communication and integrally connected with the predetermined reaction site. - View Dependent Claims (84, 85, 86, 87)
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88. A method, comprising:
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providing a chip having a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site;
providing material in the predetermined reaction site;
directing light from a source within the chip at the material; and
producing an image of the material.
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89. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
a filter able to filter light entering or exiting the predetermined reaction site, wherein the filter is integrally connected to the chip.
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90. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
a light-interacting component integrally connected to the predetermined reaction site.
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91. A apparatus, comprising:
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a chip comprising a predetermined reaction site having a volume of less than about 1 ml; and
an actuator able to target a first cell type within the predetermined reaction site without targeting a second cell type.
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92. An apparatus, comprising:
a chip comprising a predetermined reaction site having an inlet, an outlet, and a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site, wherein the chip is substantially transparent.
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93. A method, comprising:
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providing a chip comprising a predetermined reaction site having an inlet, an outlet, and a volume of less than about 1 ml, the predetermined reaction site constructed and arranged to maintain at least one living cell at the site; and
optically addressing the predetermined reaction site. - View Dependent Claims (94, 95, 96)
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Specification