Modulated chemical sensors
First Claim
1. A composition comprising a plurality of magnetic probes, said probes comprising one or more sensing agents, said probes further comprising an orienting agent configured to orient said probes in a direction of a magnetic field, and wherein said probe is configured so that said sensing agent will emit different fluxes of light in different magnetic field orientations.
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Accused Products
Abstract
The present invention relates to modulated (e.g., magnetically modulated) chemical sensors. In particular, the present invention relates to particles comprising fluorescent indicator dyes and methods of using such particles. Magnetic fields and/or Brownian motion modulate an optical property of the particle to distinguish it from background signals. The present invention thus provides improved methods of detecting a wide variety of analytes in fluids, fluid samples, cells and tissues.
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Citations
20 Claims
- 1. A composition comprising a plurality of magnetic probes, said probes comprising one or more sensing agents, said probes further comprising an orienting agent configured to orient said probes in a direction of a magnetic field, and wherein said probe is configured so that said sensing agent will emit different fluxes of light in different magnetic field orientations.
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9. A system comprising:
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a) a composition comprising a plurality of magnetic probes, said probes comprising one or more sensing agents, said probes further comprising an orienting agent configured to orient said probes in a direction of a magnetic field, and wherein said probe is configured so that said sensing agent will emit different fluxes of light in different magnetic field orientations; and
b) an optical detection component configured to detect said different fluxes of light from said probes. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A method of detecting analytes in a sample, comprising:
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a) providing i) a sample comprising a plurality of probes, said probes comprising one or more sensing agents, wherein said probes are configured so that said sensing agent will emit different fluxes of light in different probe orientations;
ii) a device configured for the detection of said different fluxes of light from said probes; and
b) detecting said different fluxes of light with said device to generate modulated probe signal and unmodulated background signal. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification