Microseeding device for gene delivery by microneedle injection
First Claim
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1. A microseeding assembly for delivering genetic material from a dispenser to a target site, the assembly comprising:
- a housing;
a matrix of microneedles disposed on a translatable shaft at one end of the housing;
an integrated dispenser support assembly connected to the housing for supporting a genetic material dispenser, wherein the support assembly includes an actuator for initiating the delivery of genetic material from the dispenser to the microneedles; and
a drive assembly connected to the housing and communicating with the actuator and the microneedles to initiate delivery of genetic material to the microneedles and to oscillate the microneedles at a predetermined frequency.
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Abstract
An apparatus is provided to enable the direct gene transfer of genetic material into a target cell site (“microseeding”), as a means of obtaining long term expression of native or non-native polypeptides in a host. The apparatus includes a matrix of microneedles that oscillate at a predetermined frequency and receive the genetic material from a delivery system that is integrated with the apparatus.
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Citations
17 Claims
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1. A microseeding assembly for delivering genetic material from a dispenser to a target site, the assembly comprising:
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a housing;
a matrix of microneedles disposed on a translatable shaft at one end of the housing;
an integrated dispenser support assembly connected to the housing for supporting a genetic material dispenser, wherein the support assembly includes an actuator for initiating the delivery of genetic material from the dispenser to the microneedles; and
a drive assembly connected to the housing and communicating with the actuator and the microneedles to initiate delivery of genetic material to the microneedles and to oscillate the microneedles at a predetermined frequency. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification