Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors

• US 20040058950A1
• Filed: 07/07/2003
• Published: 03/25/2004
• Est. Priority Date: 07/09/2002
• Status: Abandoned Application

• Current Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Pairet, Michel, Pieper, Michael P., Meade, Christopher J. M.
• Application Number:
  US10/614,365
• Publication Number:
  US 20040058950A1
• Time in Patent Office: Days
• US Class Current: 514/291
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 31/46 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
• CPC Class Codes: A61K 31/4745 condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 9/0073 Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M

Abstract

The present invention relates to novel pharmaceutical compositions based on new anticholinergics and PDE-IV inhibitors, processes for preparing them and their use in the treatment of respiratory tract diseases.

Claims

1. ) A pharmaceutical composition comprising one or more anticholinergics of formula 1

2. ) A pharmaceutical composition according to claim 1, wherein X⁻

denotes an anion selected from chloride, bromide, iodide, sulphate, phosphate, methanesulphonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate and p-toluenesulphonate.

3. ) A pharmaceutical composition according to claim 1, wherein substances 1 and 2 are present either together in a single formulation or in two separate formulations.

4. ) A pharmaceutical composition according to claim 1, wherein in the compound of formula 1 X⁻

is a negatively charged anion selected from chloride, bromide, 4-toluenesulphonate and methanesulphonate.

5. ) A pharmaceutical composition according to claim 1, wherein in the compound of formula 1 X⁻

denotes bromide.

6. ) A pharmaceutical composition according to claim 1, wherein 2 is selected from enprofylline, theophylline, roflumilast, ariflo, Bay-198004, CP-325,366, BY343, D-4396 (Sch-351591), V-11294A, AWD-12-281, N-(3,5-dichloro-1-oxo-pyridin-4-yl)-4-difluoromethoxy-3-cyclopropylmethoxybenzamide and the tricyclic nitrogen heterocycles of formula 2a

7. ) A pharmaceutical composition according to claim 1, wherein 2 is selected from enprofylline, roflumilast, ariflo, AWD-12-281, N-(3,5-dichloro-1-oxo-pyridin-4-yl)-4-difluoromethoxy-3-cyclopropylmethoxybenzamide and the tricyclic nitrogen heterocycles of formula 2a.

8. ) A pharmaceutical composition according to claim 1, wherein the weight ratios of 1 to 2 are in the range from 1:

100 to 100;

1.

9. ) A pharmaceutical composition according to claim 1, wherein the weight ratios of 1 to 2 are in the range from 1:

80 to 80;

1.

10. ) A pharmaceutical composition according to claim 1, wherein a single dose for administration corresponds to a dose of the active substance combination 1 and 2 of 0.01 to 10000 μ

g

11. ) A pharmaceutical composition according to claim 1, wherein a single dose for administration corresponds to a dose of the active substance combination 1 and 2 of 0.1 to 2000 μ

g.

12. ) A pharmaceutical composition according to claim 1, wherein it is in the form of a formulation suitable for inhalation.

13. ) A pharmaceutical composition according to claim 12, wherein it is a formulation selected from inhalable powders, propellant-containing inhalable aerosols and propellant-free inhalable solutions or suspensions.

14. ) A pharmaceutical composition according to claim 13, wherein it is an inhalable powder which comprises 1 and 2 in admixture with a suitable physiologically acceptable excipient selected from monosaccharides, disaccharides, oligo- and polysaccharides, polyalcohols, salts, or mixtures of these excipients with one another.

15. ) An inhalable powder according to claim 14, wherein the excipient has a maximum average particle size of up to 250 μ

m

16. ) An inhalable powder according to claim 14, wherein the excipient has a maximum average particle size of between 10 and 150 μ

m.

17. ) A capsule containing an inhalable powder according to claim 14.

18. ) A pharmaceutical composition according to claim 13, wherein it is an inhalable powder which contains only substances 1 and 2 as its ingredients.

19. ) A pharmaceutical composition according to claim 13, wherein it is a propellant-containing inhalable aerosol which contains 1 and 2 in dissolved or dispersed form.

20. ) A propellant-containing inhalable aerosol according to claim 19, containing a propellant gas selected from a hydrocarbon or halohydrocarbon.

21. ) A propellant-containing inhalable aerosol according to claim 19, containing a propellant gas selected from n-propane, n-butane, isobutene, chlorinated and/or fluorinated derivatives of methane, ethane, propane, butane, cyclopropane or cyclobutane.

22. ) A propellant-containing inhalable aerosol according to claim 20, wherein the propellant gas is TG134a, TG227, or a mixture thereof.

23. ) A propellant-containing inhalable aerosol according to claim 19, wherein it optionally contains one or more other ingredients selected from cosolvents, stabilisers, surfactants, antioxidants, lubricants and means for adjusting the pH.

24. ) A propellant-containing inhalable aerosol according to claim 19, wherein it contains up to 5 wt.-% of active substance 1 and/or 2.

25. ) A pharmaceutical composition according to claim 13, wherein it is a propellant-free inhalable solution or suspension which contains a solvent selected from water, ethanol or a mixture of water and ethanol.

26. ) An inhalable solution or suspension according to claim 25, wherein the pH is 2-7.

27. ) An inhalable solution or suspension according to claim 25, wherein the pH is 2-5.

28. ) An inhalable solution or suspension according to claim 26, wherein the pH is adjusted by means of an acid selected from hydrochloric acid, hydrobromic acid, nitric acid, sulphuric acid, ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid and propionic acid or mixtures thereof.

29. ) An inhalable solution or suspension according to claim 25, wherein it optionally contains other co-solvents and/or excipients.

30. ) An inhalable solution or suspension according to claim 29, containing a co-solvent selected from ingredients which contain hydroxyl groups or other polar groups.

31. ) An inhalable solution or suspension according to claim 29, containing a co-solvent selected from isopropyl alcohol, propyleneglycol, polyethyleneglycol, polypropyleneglycol, glycolether, glycerol, polyoxyethylene alcohols and polyoxyethylene fatty acid esters.

32. ) An inhalable solution or suspension according to claim 29, containing an excipient selected from surfactants, stabilisers, complexing agents, antioxidants and/or preservatives, flavorings, pharmacologically acceptable salts and/or vitamins.

33. ) An inhalable solution or suspension according to claim 32, containing a complexing agent selected from editic acid or a salt of editic acid.

34. ) An inhalable solution or suspension according to claim 33 containing sodium edentate.

35. ) An inhalable solution or suspension according to claim 32, containing an antioxidant selected from ascorbic acid, vitamin A, vitamin E and tocopherols.

36. ) An inhalable solution or suspension according to claim 32, containing a preservative selected from cetyl pyridinium chloride, benzalkonium chloride, benzoic acid and benzoates.

37. ) An inhalable solution or suspension according to claim 29, containing, in addition to the substances 1 and 2 and the solvent, only benzalkonium chloride and sodium edetate.

38. ) An inhalable solution or suspension according to claim 29, containing, in addition to the substances 1 and 2 and the solvent, only benzalkonium chloride.

39. ) An inhalable solution or suspension according to claim 25, wherein it is a concentrate or a sterile ready-to-use inhalable solution or suspension.

40. ) An inhaler containing a capsule according to claim 17.

41. ) An inhaler containing an inhalable solution according to claim 25.

42. ) A nebuliser containing an inhalable solution according to claim 39.

43. ) A method of treating an inflammatory or obstructive disease of the respiratory tract comprising administering to a patient in need of such treatment a therapeutically effective amount of a pharmaceutical composition according to claim 1.