Intra-aortic renal delivery catheter
First Claim
1. A renal flow system, comprising:
- a renal flow device with a renal flow assembly that is adapted to be positioned at a location within an aorta of a patient adjacent to at least one renal artery ostium and to locally direct a volume of fluid from the location and substantially into the at least one renal artery via its ostium while allowing a substantial volume of aortic blood to flow downstream across the location; and
a delivery catheter having an elongate tubular body with a proximal end portion, a distal end portion, and a delivery lumen extending between a proximal port along the proximal end portion and a distal port along the distal end portion;
wherein the renal flow device is adapted to allow the delivery catheter to be positioned across the location with the distal port positioned at an upstream location that is upstream from the location adjacent the renal ostium, and also with the proximal port on the proximal end portion located externally of the patient'"'"'s body, while the renal flow device is positioned at the location.
8 Assignments
0 Petitions
Accused Products
Abstract
A renal flow system and method direct fluid into renal arteries from a location within the aorta. A renal flow assembly has a tapered tube that is adjustable between a radially collapsed condition for delivery to the location through a delivery sheath and a radially expanded condition that divides aortic flow into exterior and interior paths. The tube'"'"'s wall is made from a sheet of flexible material, such as PTFE or ePTFE. Two, nickel-titanium rings radially support the tube'"'"'s ends and are connected by a longitudinal spine support. A fluid delivery assembly injects drug to flow along the exterior flow path and the tubular wall directs the agent into the renal artery ostium. The tube'"'"'s taper has localized shape for circumferential agent mixing to infuse both kidneys'"'"' renals. The flow assembly allows an interventional device, e.g. delivery catheter, to advance across the location while directing blood into the renals and perfusing downstream circulation. The renal flow assembly and distal device are used within a common guide sheath through a single puncture wound. Vasodilators, antioxidants, or diuretics are delivered to the kidneys to treat/prevent RCN, CHF, or ARF.
-
Citations
111 Claims
-
1. A renal flow system, comprising:
-
a renal flow device with a renal flow assembly that is adapted to be positioned at a location within an aorta of a patient adjacent to at least one renal artery ostium and to locally direct a volume of fluid from the location and substantially into the at least one renal artery via its ostium while allowing a substantial volume of aortic blood to flow downstream across the location; and
a delivery catheter having an elongate tubular body with a proximal end portion, a distal end portion, and a delivery lumen extending between a proximal port along the proximal end portion and a distal port along the distal end portion;
wherein the renal flow device is adapted to allow the delivery catheter to be positioned across the location with the distal port positioned at an upstream location that is upstream from the location adjacent the renal ostium, and also with the proximal port on the proximal end portion located externally of the patient'"'"'s body, while the renal flow device is positioned at the location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 98, 99, 100, 101, 102, 103, 104)
-
-
24. A flow isolation assembly for dividing and substantially isolating first and second paths of blood flowing within a blood vessel in a patient, comprising:
-
a delivery shaft with a proximal end portion and a distal end portion;
a tubular member having a tubular wall formed by a sheet of substantially flexible material that is substantially impermeable to blood, and having an outer surface with an outer diameter, and also having an inner surface that defines an interior passageway that extends along an axis between first and second openings along first and second end portions, respectively, of the tubular member; and
at least one radial support member that is secured to the distal end portion of the delivery shaft, and having a ring-shaped support wire with a circumference, and that is adjustable between a radially collapsed condition and a radially expanded condition relative to the axis;
wherein the tubular member along one end portion is secured substantially along the circumference of the ring-shaped support wire such that the tubular member extends along the axis from the one end portion corresponding to the radial support member to the other end portion;
wherein in the radially collapsed condition the radial support member is relatively radially collapsed with respect to the axis such that the tubular member has collapsed outer and inner diameters that are sufficiently small so that the tubular member may be delivered to the location within the blood vessel through a radially confining delivery lumen of a delivery sheath with the first and second open end portions having respective downstream and upstream positions relative to blood flowing along the blood vessel;
wherein in the radially expanded condition at the location the radial support member is radially expanded relative to the axis such that the tubular member has expanded outer and inner diameters that are substantially larger than the collapsed outer and inner diameters, respectively, but wherein the outer diameter of the tubular member at least along the upstream end portion of the tubular member is less than an inner diameter of the blood vessel wall; and
wherein the tubular member in the radially expanded condition is adapted to substantially prevent fluid communication through the tubular wall between an interior flow path along the interior passageway and an exterior flow path along a circumferential region of the blood vessel surrounding the outer surface of the tubular member and located between the outer surface of the tubular wall and the blood vessel wall at least along the upstream end portion of the tubular member. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
-
-
44. A medical device system, comprising:
-
a delivery shaft with a proximal end portion and a distal end portion having a longitudinal axis;
a tubular member secured to the distal end portion of the delivery shaft and having a proximal end portion, a distal end portion, and a tubular wall comprising a sheet of material formed into a tubular shape with an outer surface and an inner surface that defines an interior passageway extending along the axis between a proximal open end along the proximal end portion of the tubular member and a distal open end along the distal end portion of the tubular member;
a proximal radial support member secured to the distal end portion of the delivery shaft and comprising a ring-shaped support wire also secured substantially along a circumference of the proximal end portion of the tubular member; and
a distal radial support member comprising a ring-shaped support wire secured substantially along a circumference of the distal end portion of the tubular member;
wherein the tubular member has a distally tapered shape that tapers from a proximal outer diameter along the proximal end portion where secured to the proximal radial support member to a distal outer diameter that is less than the proximal outer diameter along the distal end portion of the tubular member where secured to the distal radial support member. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 64)
-
-
57. A system for locally delivering a volume of a fluid agent to a desired location within a patient, comprising:
-
a delivery shaft having a proximal end portion and a distal end portion, a tubular member secured to the distal end portion of the delivery shaft and having a proximal end portion, a distal end portion, and a tubular wall comprising a sheet of material formed into a tubular shape with an outer surface and an inner surface that defines an interior passageway extending between a proximal open end along the proximal end portion of the tubular member and a distal open end along the distal end portion of the tubular member;
a bladder located along the distal end portion of the tubular wall and that defines a reservoir; and
a fluid delivery passageway that is fluidly coupled to the reservoir and also to a proximal port located along the proximal end portion of the delivery shaft;
wherein the proximal port is adapted to couple to a source of a fluid agent; and
wherein the bladder further comprises an outer wall that is permeable to the fluid agent and that is positioned to allow the fluid agent to flow from within the reservoir of the bladder, through the outer wall, and principally into an exterior circumferential area surrounding the outer surface of the tubular member. - View Dependent Claims (58, 59, 60, 61, 62, 63)
-
-
65. A renal flow system, comprising:
-
a renal flow device having a delivery shaft with a proximal end portion and a distal end portion, and also having a renal flow assembly on the distal end portion with an expandable tubular member; and
a fluid agent delivery system cooperating with the renal flow assembly of the renal flow device;
wherein the tubular member is secured to the distal end portion of the delivery shaft and has a proximal end portion, a distal end portion, and a tubular body with an outer surface and an inner surface that defines an interior passageway extending between respective proximal and distal open ends located along the proximal and distal end portions of the tubular member, respectively;
wherein the tubular member is adjustable between a radially collapsed condition and a radially expanded condition;
wherein in the radially collapsed condition the tubular member is adapted to be positioned at a location within an aorta of a patient adjacent to at least one renal artery ostium along the aorta and with the proximal end portion of the tubular member located downstream from the ostium and the distal end portion of the tubular member located upstream from the ostium;
wherein in the radially expanded condition at the location the tubular member is adapted to substantially divide aortic blood flow between an interior flow path within the interior passageway and an exterior flow path located within a exterior circumferential area surrounding the outer surface of the tubular member and between the outer surface and the wall of the aorta at the location;
wherein in the radially expanded condition the tubular member is further adapted to direct the exterior flow path substantially into the renal artery via its ostium, and to allow the aortic blood in the interior flow path to flow downstream past the location;
wherein the fluid agent delivery system is adapted to locally deliver a volume of fluid agent into the exterior flow path at a localized circumferential region around the circumference of the tubular member; and
wherein the tubular member has a localized shape corresponding with at least the localized circumferential region around the tubular member and that forms a mixing region that is adapted to promote substantial mixing of the fluid agent delivered into the localized circumferential region with blood flowing along other circumferential regions of the exterior flow path. - View Dependent Claims (66, 67, 68, 69, 70, 71, 72)
-
-
73. A renal flow system, comprising:
-
a renal flow device having a delivery shaft with a proximal end portion and a distal end portion, and also having a renal flow assembly located along the distal end portion;
means for dividing a cross-section of aortic blood flow at a location within an aorta adjacent to at least one renal artery ostium into an interior flow path flowing downstream across the location and an exterior flow path that substantially circumferentially surrounds the interior flow path;
means for substantially directing the blood in the exterior flow path to flow substantially into the at least one renal artery ostium along the aorta at the location;
means for allowing the blood in the interior flow path to flow substantially downstream from the location;
means for substantially isolating the exterior and interior flow paths from each other along the location;
means for locally delivering a volume of fluid agent substantially into a localized circumferential portion of the exterior flow path along the distal end portion of the tubular member; and
means for mixing the volume of fluid agent that is delivered into the localized circumferential portion of the exterior flow path across a substantial circumferential portion of the exterior flow path circumferentially around the tubular member such that a substantial portion of the agent is delivered via the second flow path into each of the plurality of renal artery ostia. - View Dependent Claims (74, 75, 76, 77, 78, 79)
-
-
80. A method for providing localized medical care to a renal system in a patient, comprising:
-
positioning a distal end portion of a catheter at a location within the patient'"'"'s aorta that is adjacent to an ostium of at least one renal artery extending from the aorta;
using the distal end portion of the catheter from within the aorta at the location, directing a volume of fluid within the aorta to be locally delivered primarily into the at least one renal artery via its ostium;
while locally delivering the volume of fluid into the at least one renal artery, allowing a substantial volume of aortic blood to flow downstream past the location and into the patient'"'"'s downstream circulation downstream from the renal artery ostium;
substantially isolating the volume of fluid being directed into the at least one renal artery from mixing with the substantial volume of aortic blood flowing downstream from the location; and
conducting an interventional medical procedure at least in part at an upstream location upstream from the location while locally directing the volume of fluid into the at least one renal artery, and while allowing the substantial volume of aortic blood to flow downstream from the ostium, and also while substantially isolating the volume of fluid from mixing with the substantial volume of aortic blood flowing downstream. - View Dependent Claims (81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 105, 106, 107, 108, 109, 110, 111)
-
-
97. A method for directing fluid to a renal system in a patient, comprising:
-
locally delivering a volume of fluid to at least one renal artery in the patient; and
while locally delivering the volume of fluid to the at least one renal artery, positioning a medical device within an aorta of the patient upstream from an ostium of the at least one renal artery along the aorta of the patient.
-
Specification