Method for transforming phase spectra to absorption spectra
First Claim
1. A method for determining a concentration of an analyte within a material sample, said method comprising:
- inducing said material sample to emit electromagnetic energy in a time-varying manner;
measuring, at at least one wavelength, said induced electromagnetic energy emitted by said material sample;
determining a phase of said electromagnetic energy;
converting said phase into an absorption value; and
determining said concentration of said analyte based at least in part on said absorption.
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Abstract
A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.
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Citations
24 Claims
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1. A method for determining a concentration of an analyte within a material sample, said method comprising:
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inducing said material sample to emit electromagnetic energy in a time-varying manner;
measuring, at at least one wavelength, said induced electromagnetic energy emitted by said material sample;
determining a phase of said electromagnetic energy;
converting said phase into an absorption value; and
determining said concentration of said analyte based at least in part on said absorption. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for determining a concentration of an analyte within a material sample, said method comprising:
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determining at least a portion of a phase spectrum based on electromagnetic energy emitted by said material sample;
converting said at least a portion of said phase spectrum into at least a portion of an absorption spectrum; and
determining said concentration based on said at least a portion of said absorption spectrum. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. An analyte detection system comprising:
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a detector array;
a processing circuit in communication with said detector array; and
a module executable by said processing circuit whereby said processing circuit converts a phase spectrum, said phase spectrum based on electromagnetic energy emitted by a material sample and measured by said detector array, into an absorption spectrum and determines a concentration of an analyte within said material sample based on said absorption spectrum. - View Dependent Claims (19, 20, 21)
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22. A method of estimating analyte concentration in a sample comprising:
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applying a time varying temperature to a portion of a sample;
measuring time varying infrared radiation intensity received from said sample in at least one wavelength band;
calculating an absorption coefficient α
in said wavelength band based at least in part on said time varying infrared radiation intensity received from said sample.
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23. The method of claim 23, additionally comprising calculating a phase difference θ
- between said time varying temperature and said time varying infrared radiation intensity and calculating said absorption coefficient α
based at least in part on said phase difference θ
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- between said time varying temperature and said time varying infrared radiation intensity and calculating said absorption coefficient α
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24. The method of claim 24, wherein said absorption coefficient is calculated from said phase difference according to the formula
Specification