Molecularly imprinted polymers for the treatment and diagnosis of medical conditions
First Claim
1. A method for treating a subject for a disease selected from the group consisting of heart disease, gallstone disease, colorectal cancer, a precursor of colorectal cancer, gastroesophageal reflux diseases, esophageal cancer, COX-2 mediated inflammatory conditions and cholestatic liver disease, the method comprising:
- orally administering a molecularly imprinted polymer to the subject.
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Abstract
Improved molecularly imprinted polymers (MIPs) with both higher and more specific binding capacity for particular bile acids and/or salts, including the synthesis of such MIPs, the compounds themselves, and specific applications thereof. As an example of a particularly preferred specific application of these compounds, the present invention encompasses the use of the MIPs as sequestrants in the gastrointestinal tract, particularly in order to bind and therefore remove toxins from the gastrointestinal tract. In addition, the present invention is also useful for treatment of various diseases which are related to, and/or characterized by, an effect of bile acids and salts, such as atherosclerosis, liver disease and various diseases of the gastrointestinal tract. The MIP compounds of the present invention are also useful for combination therapy with other medications and for diagnosis and monitoring of diseases.
45 Citations
23 Claims
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1. A method for treating a subject for a disease selected from the group consisting of heart disease, gallstone disease, colorectal cancer, a precursor of colorectal cancer, gastroesophageal reflux diseases, esophageal cancer, COX-2 mediated inflammatory conditions and cholestatic liver disease, the method comprising:
orally administering a molecularly imprinted polymer to the subject. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for treating a subject for a heart disease, the method comprising:
administering a molecularly imprinted polymer (MIP) compound to the subject. - View Dependent Claims (8, 9, 10, 11, 12)
- 13. A method for treating a subject for a disease of the gastrointestinal tract, the method comprising the step of administering a molecularly imprinted polymer (MIP) compound to the subject.
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15. A method for treating a subject for a disease characterized by a COX-2 mediated inflammatory condition, the method comprising the step of administering a molecularly imprinted polymer (MIP) compound to the subject.
- 16. A method for performing combination therapy for treating a subject for a disease, the method comprising the step of administering a combination of a molecularly imprinted polymer (MIP) compound and at least one additional drug to the subject.
Specification