Surface dissolution and/or bulk erosion controlled release compositions and devices
First Claim
1. A composition for controlled release of an active agent comprising:
- a wax material;
a fat material;
an active agent;
a water sensitive material; and
optionally a surface active material.
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Abstract
The present invention relates to a controlled release system comprising matrix compositions which control the lag time and release rate of the composition, as well as pharmaceutical and other active ingredients included in the composition, through surface dissolution and/or bulk erosion of the system. The controlled release system can be used to target and control the release of active ingredients onto certain regions of the gastrointestinal tract including the stomach and the small intestine. The matrix compositions of the present invention can be comprised of the following components: a wax material, fat material, water sensitive material and surface active material.
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Citations
94 Claims
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1. A composition for controlled release of an active agent comprising:
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a wax material;
a fat material;
an active agent;
a water sensitive material; and
optionally a surface active material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88)
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64. A method for delivering an active substance to a preselected environment;
- said method comprising introducing to said environment a control release composition, said control release comprising;
a wax material;
a fat material;
an active agent;
a water sensitive material; and
optionally a surface active material, wherein introducing of said composition into said environment permits degradation of said composition and release of said active agent. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78)
- said method comprising introducing to said environment a control release composition, said control release comprising;
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89. A method for producing a controlled release composition comprising the steps of:
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(i) heating a wax material to a temperature above the melting point of the wax material to form a melt;
(ii) heating a fat material to a temperature above the melting point of the fat material to form a melt;
(iii) dissolving or dispersing a surface active agent into the melt of the wax or melt of the fat;
(iv) combining the melt of the wax with the melt of the fat;
(v) dissolving or dispersing one or more first active agents into the combined melt of the wax and fat;
(vi) optionally dissolving or dispersing one or more second encapsulated active agents into the combined melt of the wax and fat;
(vii) dispersing a water sensitive material into the combined melt of the wax and fat; and
(viii) cooling the melt to form a dry powder composition.
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90. A method for producing articles formed of a controlled release composition comprising the steps of:
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(i) heating a wax material to a temperature above the melting point of the wax material to form a melt;
(ii) heating a fat material to a temperature above the melting point of the fat material to form a melt;
(iii) dissolving or dispersing a surface active agent into the melt of the wax or melt of the fat;
(iv) combining the melt of the wax with the melt of the fat;
(v) dissolving or dispersing one or more first active agents into the combined melt of the wax and fat;
(vi) optionally dissolving or dispersing one or more second encapsulated active agents into the combined melt of the wax and fat;
(vii) dispersing a water sensitive material into the combined melt of the wax and fat;
(viii) cooling the melt to form a dry powder composition;
or(ix) molding the melt into a predetermined geometric dimensions or shapes. - View Dependent Claims (93, 94)
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91. A composition for controlled release of a device comprising:
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a wax material;
a fat material;
an active agent;
a water sensitive material; and
said device, wherein said composition is a carrier for said device. - View Dependent Claims (92)
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Specification