Release of therapeutic agents in a vessel or tissue
First Claim
1. A physiologically compatible liposome containing at least one therapeutic agent;
- said liposome comprising dioleoylphosphatidylethanolamine, dipalmitoylphosphatidylcholine and cholesterol in a respective weight ration of about 7;
3;
5, having a diameter of at least about 7 microns but no more than about 300 microns, and a residence time in a body fluid of at least about one half-minute but less than about 3 minutes.
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Abstract
Particles larger than 7 microns in diameter and containing a therapeutic material are described. Such particles are sufficiently large to lodge in tissue or a blood vessel and can be made to rapidly degrade therein before creating infarcts. Rapid degradation of liposomes containing a therapeutic agent can be achieved by either preparing the liposome in a high salt solution or incorporating in the liposome a component which is stable at or below room temperature, but which becomes unstable at 35° C. or higher. Such particles are useful in delivering, for example, angiogenic growth factors or genes coding for angiogenic growth factors into the coronary arteries of the heart or the heart muscle, as well as other therapeutic agents into organs or tissues or blood vessels feeding the same to achieve a desired effect.
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Citations
40 Claims
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1. A physiologically compatible liposome containing at least one therapeutic agent;
- said liposome comprising dioleoylphosphatidylethanolamine, dipalmitoylphosphatidylcholine and cholesterol in a respective weight ration of about 7;
3;
5, having a diameter of at least about 7 microns but no more than about 300 microns, and a residence time in a body fluid of at least about one half-minute but less than about 3 minutes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- said liposome comprising dioleoylphosphatidylethanolamine, dipalmitoylphosphatidylcholine and cholesterol in a respective weight ration of about 7;
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21. A method for introducing a therapeutic agent into the vasculature of a patient which comprises injecting into a patient'"'"'s blood stream physiologically compatible liposomes containing at least one therapeutic agent, which particles have a diameter of at least about 7 microns but no more than about 300 microns;
- said liposomes comprising dioleoylphosphatidylethanolamine, dipalmitoylphosphatidylcholine and cholesterol in a respective weight ratio of about 7;
3;
5 and having a residence time in the patient'"'"'s blood stream of at least about one-half minute but less than about 3 minutes. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
- said liposomes comprising dioleoylphosphatidylethanolamine, dipalmitoylphosphatidylcholine and cholesterol in a respective weight ratio of about 7;
Specification