Transdermal drug delivery devices having coated microprotrusions
First Claim
Patent Images
1. A method of coating the surface of one or more microprojections of a microprojection array comprising the steps of:
- providing a microprojection array comprised of one or more microprojections;
treating the surface of one or more of said microprojections of said microprojection array with a method selected from group consisting of chemical pre-etching, plasma treatment, heat treating, rinsing with an alkaline detergent and rinsing with a wetting agent;
providing a coating formulation comprising an active agent;
applying said coating formulation to said treated surfaces of said one or more microprojections; and
drying said coating formulation onto said surfaces to form a coating.
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Abstract
Methods are provided for preparation of a coating on one or more microprojections of a microprojection array using wetting agents either as a pretreatment of the microprojection surfaces or incorporated in the coating formulation along with the active agent.
98 Citations
23 Claims
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1. A method of coating the surface of one or more microprojections of a microprojection array comprising the steps of:
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providing a microprojection array comprised of one or more microprojections;
treating the surface of one or more of said microprojections of said microprojection array with a method selected from group consisting of chemical pre-etching, plasma treatment, heat treating, rinsing with an alkaline detergent and rinsing with a wetting agent;
providing a coating formulation comprising an active agent;
applying said coating formulation to said treated surfaces of said one or more microprojections; and
drying said coating formulation onto said surfaces to form a coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 22)
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15. A method of coating the surface of one or more microprojections of a microprojection array comprising the steps of:
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providing a microprojection array comprised of one or more microprojections;
providing a coating formulation comprising an active agent and a wetting agent;
applying said coating formulation to said surfaces of said one or more microprojections; and
drying said coating formulation onto said surfaces to form a coating. - View Dependent Claims (16, 19, 20, 21, 23)
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Specification