Miniaturized fluid delivery and analysis system
First Claim
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1. A fluid delivery and analysis system comprised of:
- a plastic fluidic device comprising;
upper substrate, a lower substrate, and flexible intermediate interlayer;
at least one channel of capillary dimensions and at least one main reaction chamber connected to said channel;
at least one pumping chamber formed in the upper substrate and a through-hole in the lower substrate corresponding to said pumping chamber;
at least two check valve structures adapted to restrict flow in one direction only from either an upper substrate channel to a lower substrate channel or from a lower substrate channel to an upper substrate channel;
at least one micropump comprised of the pumping chamber and at least two check valve structures; and
an actuator system comprised of at least one linear actuator corresponding to the pump chambers.
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Abstract
The present invention provides a method for combining a fluid delivery system with an analysis system for performing immunological or other chemical of biological assays. The method comprises a miniature plastic fluidic cartridge containing a reaction chamber with a plurality of immobilized species, a capillary channel, and a pump structure along with an external linear actuator corresponding to the pump structure to provide force for the fluid delivery. The plastic fluidic cartridge can be configured in a variety of ways to affect the performance and complexity of the assay performed.
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Citations
11 Claims
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1. A fluid delivery and analysis system comprised of:
a plastic fluidic device comprising;
upper substrate, a lower substrate, and flexible intermediate interlayer;
at least one channel of capillary dimensions and at least one main reaction chamber connected to said channel;
at least one pumping chamber formed in the upper substrate and a through-hole in the lower substrate corresponding to said pumping chamber;
at least two check valve structures adapted to restrict flow in one direction only from either an upper substrate channel to a lower substrate channel or from a lower substrate channel to an upper substrate channel;
at least one micropump comprised of the pumping chamber and at least two check valve structures; and
an actuator system comprised of at least one linear actuator corresponding to the pump chambers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
Specification