Compositions with enhanced antimicrobial efficacy against acanthamoebae
First Claim
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1. A method for enhancing antimicrobial efficacy of a composition against acanthamoebae comprising including a polycation material in said composition.
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Abstract
Ophthalmic compositions such as eye drop and contact lens treating solutions include a polycationic material to enhance antimicrobial efficacy against protozoans such as acanthamoebae. One preferred class of polycationic materials is cationic cellulose derivatives.
42 Citations
18 Claims
- 1. A method for enhancing antimicrobial efficacy of a composition against acanthamoebae comprising including a polycation material in said composition.
- 10. An ophthalmic composition comprising a primary antimicrobial agent, and a polycation material in an aqueous solution, wherein said polycation material enhances the antimicrobial efficacy of the primary antimicrobial agent.
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16. A method for enhancing antimicrobial efficacy of a contact lens against acanthamoebae, comprising contacting said contact lens with a solution comprising a primary antimicrobial agent and a polycation material.
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17. A method for enhancing antimicrobial efficacy of an ophthalmic composition against acanthamoebae, comprising including in said composition a cationic cellulose material.
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18. An ophthalmic composition comprising a primary antimicrobial agent and a polycation material that enhances the antimicrobial efficacy of said primary antimicrobial agent, wherein said composition has enhanced efficacy against acanthamoebae than a similar composition lacking the polycation material.
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