Formulation of boronic acid compounds
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Abstract
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1):
in which Z1 and Z2 are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.
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Citations
55 Claims
- 1. A compound of the formula (1):
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16. The compound D-mannitol N-(2-pyrazine)carbonyl-L-phenylalanine-L-leucine boronate.
- 17. A lyophilized compound of the formula (1):
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32. The lyophilized compound D-mannitol N-(2-pyrazine)carbonyl-L-phenylalanine-L-leucine boronate.
- 35. A method of preparing a lyophilized compound of the formula (1):
Specification