Intraluminal needle injection substance delivery system with filtering capability

• US 20040064099A1
• Filed: 09/30/2002
• Published: 04/01/2004
• Est. Priority Date: 09/30/2002
• Status: Abandoned Application

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Chiu, Jessica G.
• Application Number:
  US10/260,742
• Publication Number:
  US 20040064099A1
• Time in Patent Office: Days
• US Class Current: 604/164.01
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61M 25/0084 being one or more injection needles

Abstract

An intraluminal needle injection substance delivery system includes a delivery catheter having a delivery lumen extending therethrough to provide a conduit by which a drug delivery device can extend through to inject a therapeutic drug or substance to an area of treatment in a body vessel. The delivery system includes filtering capability for capturing possible unwanted debris which may be entrained in the patient'"'"'s vasculature. The filtering device used in accordance with the delivery catheter may include a filtering element placed downstream from the area in which the therapeutic drug or substance is to be administered. The delivery lumen can be attached to the filtering device for deployment within the patient'"'"'s vasculature. In this fashion, as the filtering device is expanded from a collapsed, delivery position to an expanded position within the patient'"'"'s vasculature, the end of the delivery lumen will be positioned near or in contact with the target area in the patient'"'"'s vasculature. A substance delivery device, such as a syringe having an elongated cannula, can be placed in the delivery lumen to inject the vessel wall with a drug or other therapeutic substance.

Claims

1. A delivery system for administering therapeutic drugs or substances in a body vessel of a patient, comprising:

a delivery catheter having a proximal end and a distal end and a delivery lumen for receiving the cannula of a syringe, the delivery lumen having a distal end through which the cannula extends for the administration of a therapeutic drug or substance to the body vessel; and

means associated with the delivery catheter for capturing unwanted particles which may be entrained in the body fluid passing through the body vessel.

2. The delivery system of claim 1, further including a delivery sheath adapted to extend co-axially over the delivery catheter and the particle capturing means when the delivery system is being advanced within the body vessels of the patient.

3. The delivery system of claim 1, wherein the particle capturing means includes means for deployment in the body vessel.

4. The delivery system of claim 3, wherein the distal end of the delivery lumen is coupled to the particle capturing means and is positioned within the body vessel when the particle capturing means is deployed.

5. The delivery system of claim 4, wherein the particle filtering means is an embolic filtering device having an expandable cage and a filter element attached to the expandable cage, the distal end of the delivery lumen being attached to the filtering device.

6. The delivery system of claim 5, wherein the expandable cage of the filtering device is self-expanding.

7. The delivery system of claim 6, further including a delivery sheath adapted to extend co-axially over the delivery catheter and the filtering device when the drug delivery system is being advanced within the body vessels of the patient.

8. The delivery system of claim 7, wherein the delivery sheath is adapted to extend over the filtering device to maintain a restraining force on the filtering device which is removable once the delivery sheath is retracted from the filtering device.

9. The delivery system of claim 1, wherein the delivery catheter includes a plurality of delivery lumens.

10. The delivery system of claim 1, wherein the particle capturing means is placed at a distal location from the distal end of the delivery lumen.

11. The delivery system of claim 5, wherein the expandable cage includes a proximal end and a distal end and the expandable cage is expanded through application of a force to one or both of the distal and proximal ends of the expandable cage.

12. A delivery system for administering therapeutic drugs or substances in a body vessel of a patient, comprising:

a delivery catheter having a proximal end and a distal end and a delivery lumen for receiving the cannula of a syringe, the delivery lumen having a distal end through which the cannula extends for the administration of a therapeutic drug or substance to the body vessel; and

a filtering device associated with the delivery catheter for capturing unwanted particles which may be entrained in the body fluid passing through the body vessel.

13. The delivery system of claim 12, wherein the positioning of the end of the delivery lumen is accomplished when the filtering device is deployed in the body vessel.

14. The delivery system of claim 12, wherein the filtering device is movable between an unexpanded position and an expanded position and the distal end delivery lumen is attached to the filtering device.

15. The delivery system of claim 12, wherein the filtering device includes an expandable cage and a filter element attached thereto.

16. The delivery system of claim 12, wherein the expandable cage is made from a self-expanding material.

17. The delivery system of claim 15, wherein the expandable cage includes a proximal end and a distal end and the expandable cage is expanded through application of a force to one or both of the distal and proximal ends of the expandable cage.

18. The delivery system of claim 12, further including a delivery sheath adapted to extend over the filtering device to maintain a restraining force on the filtering device which is removable once the delivery sheath is retracted from the filtering device.

19. The delivery system of claim 12, further including a delivery sheath adapted to extend co-axially over the delivery catheter and the filtering device when the delivery system is being advanced within the body vessels of the patient.

20. The delivery system of claim 15, wherein the expandable cage includes a proximal strut which extends outwardly in a radial fashion when placed in the expanded position, the end of the delivery lumen being attached thereto.

21. The delivery system of claim 12, further including a plurality of delivery lumens.

22. The delivery system of claim 12, wherein the delivery catheter has a plurality of delivery lumens and a guide wire lumen for receiving a guide wire.

23. The delivery system of claim 22, further including a guide wire which extends through the guide wire lumen.

24. The delivery system of claim 23, wherein the delivery catheter is slidable disposed for longitudinal movement along the guide wire.

25. The delivery system of claim 23, wherein the guide wire is fixed to the delivery catheter.

26. The delivery system of claim 25, wherein the guide wire is fixedly mounted to the filtering device.

27. The delivery system of claim 12, wherein the filtering device is located distal to the delivery lumen.

28. A delivery system for administering therapeutic drugs or substances in a body vessel of a patient, comprising:

a delivery catheter having a proximal end and a distal end and a delivery lumen for receiving the cannula of a syringe and a guide wire lumen for receiving a guide wire, the delivery lumen having a distal end through which the cannula extends for the administration of a therapeutic drug or substance to the body vessel;

a filtering device associated with the drug delivery catheter for capturing particles which may be entrained in the body fluid passing through the body vessel;

a guide wire disposed within the guide wire lumen; and

a delivery sheath adapted to extend co-axially over the delivery catheter and the filtering device when the delivery system is being advanced within the body vessels of the patient.

29. The delivery system of claim 28, wherein the filtering device includes an expandable cage and a filter element attached thereto.

30. The delivery system of claim 29, wherein the expandable cage is made from a self-expanding material.

31. The delivery system of claim 28, further including a plurality of delivery lumens.

32. The delivery system of claim 29, wherein the expandable cage includes a proximal strut which extends outwardly in a radial fashion when placed in the expanded position, the end of the delivery lumen being attached thereto.

33. The delivery system of claim 28, wherein the delivery catheter is slidable disposed for longitudinal movement along the guide wire.

34. The delivery system of claim 28, wherein the guide wire is fixed to the delivery catheter.

35. The delivery system of claim 34, wherein the guide wire is fixedly mounted to the filtering device.

36. The delivery system of claim 28, wherein the filtering device is located distal to the filter element.

37. A method for administering therapeutic drugs or substances intraluminally in a body vessel of a patient, comprising:

providing a delivery system including a delivery catheter having a proximal end and a distal end and a delivery lumen for receiving the cannula of a drug delivery device, the delivery lumen having a distal end through which a cannula extends for the administration of a therapeutic drug or substance to the body vessel and an filtering device associated with the delivery catheter for capturing unwanted particles which may be entrained in the body fluid passing through the body vessel;

advancing the delivery catheter intraluminally through the patient to position the end of the delivery lumen near or in contact with the location of the body vessel where the drug or substance is to be administered;

deploying the filtering device within the body vessel;

advancing the cannula of a drug delivery device through the delivery lumen placing the end of the cannula near or into the body vessel; and

administering the drug or substance to the body vessel.

38. The method of claim 37, further including:

collapsing the filtering device for removal from the body vessel.

39. The method of claim 37, wherein the filtering device is located at a distal location from the distal end of the delivery lumen.

40. The method of claim 37, further including a delivery sheath adapted to extend coaxially over the delivery catheter and the filtering device in a delivery position, the delivery sheath being retractable from the filtering device when the filtering device is to be deployed in the body vessel.

41. The method of claim 40, wherein the filtering device includes an expandable cage and a filter element attached to the expandable cage, the expandable cage being biased in an expanded position and collapsible to a delivery position.

42. The method of claim 37, wherein the filtering device is movable between an unexpanded position and an expanded position, the delivery lumen being attached to the filtering device and being positioned near or in contact with the body vessel when the filtering device is deployed in its expanded position.

43. The method of claim 42, wherein the filtering device includes an expandable cage and a filter element attached thereto, the expandable cage including a proximal strut which expands in an outward radial fashion when placed in the expanded position, the delivery lumen being attached to the proximal strut.

44. The method of claim 43, wherein the delivery catheter has plurality of delivery lumens and the expandable case has a plurality of proximal struts, each delivery lumen being attached to an individual proximal strut.

45. The method of claim 37, wherein the delivery catheter includes a guide wire lumen and the delivery system includes a guide wire disposed through the guide wire lumen.

46. The method of claim 45, wherein the delivery catheter is slidably disposed for longitudinal movement along the guide wire.

47. The method of claim 45, wherein the guide wire is fixed to the delivery catheter.

48. The method of claim 47, wherein the guide wire is fixedly mounted to the filtering device.

49. The method of claim 46, wherein the guide wire is advanced initially into the location where the drug or substance is to be administered, thereafter the delivery system being advanced along the guide wire to position the delivery catheter to the location of the body lumen where the drug or substance is to be administered.

50. The method of claim 47, wherein the guide wire and delivery system are simultaneously advanced intraluminally through the patient to position the end of the delivery lumen near or in contact with the location of the body vessel where the drug or substance is to be administered.

51. The method of claim 50, further including:

collapsing and removing the filtering device from the body vessel.

52. The method of claim 37, wherein the filtering device includes an expandable cage and a filter element attached thereto, the expandable cage having a proximal end and a distal end, the expandable cage being expandable to a deployed position by the application of an external force to either or both of the distal and proximal ends of the expandable cage.

53. The delivery system of claim 37, wherein the delivery lumen is adapted to receive the cannula of a drug delivery device which utilizes high pressure jet injection for administering the drug or therapeutic substance to the body vessel.

54. The method of claim 37, wherein the deployment of the filtering device causes a portion of the vessel wall to stretch in order to receive an injection of therapeutic drug or substance.

55. The method of claim 37, wherein the cannula of the drug delivery device pierces the body vessel in order to inject the drug or therapeutic substance into the body vessel.