Method and device for enhanced delivery of a biologically active agent through the spinal spaces into the central nervous system of a mammal
First Claim
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1. A method for enhanced and controlled delivery of a biologically active agent into the spinal structures and/or the brain of a mammal, particularly a human being that circumvents the blood brain barrier, which includes the steps of:
- providing an agent drug delivery device via catheter to the epidural space of the mammal and positioning said device within the epidural space, advancing a donor iontophoresis electrode into the epidural space of the mammal, applying a second electrode or receptor iontophoresis electrode that is constructed and arranged to be positioned at a determined internal or external position of the mammal'"'"'s body but in complementary energy gradient positioning to the first electrode, providing a potential gradient so that delivery of the biologically active agent is accomplished in a direction from said first electrode means directly into the spinal structures and/or the brain thereby essentially bypassing the blood brain barrier of the mammal; and
thereby, delivering said biologically active agent directly to the spinal structures and/or to the brain of said mammal
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Abstract
A delivery method and implantable apparatus that allows for controlled, enhanced and (pre)-programmable administration of a biologically active agent into the spinal structures and/or the brain via the epidural space of a mammal, particularly of a human being and including a feedback regulated delivery method and apparatus specifically in the treatment of neurological diseases and chronic pain.
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Citations
12 Claims
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1. A method for enhanced and controlled delivery of a biologically active agent into the spinal structures and/or the brain of a mammal, particularly a human being that circumvents the blood brain barrier, which includes the steps of:
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providing an agent drug delivery device via catheter to the epidural space of the mammal and positioning said device within the epidural space, advancing a donor iontophoresis electrode into the epidural space of the mammal, applying a second electrode or receptor iontophoresis electrode that is constructed and arranged to be positioned at a determined internal or external position of the mammal'"'"'s body but in complementary energy gradient positioning to the first electrode, providing a potential gradient so that delivery of the biologically active agent is accomplished in a direction from said first electrode means directly into the spinal structures and/or the brain thereby essentially bypassing the blood brain barrier of the mammal; and
thereby,delivering said biologically active agent directly to the spinal structures and/or to the brain of said mammal - View Dependent Claims (5, 6)
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2. A method for enhanced and controlled delivery of a biologically active agent into the spinal structures and/or the brain of a mammal, particularly a human being that circumvents the blood brain barrier, which includes the steps of:
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providing an agent drug delivery device via catheter to the epidural space of the mammal and positioning said device within the epidural space, advancing a phonophoresis device in the epidural space of the mammal, providing an energy gradient so that delivery of the biologically active agent is accomplished in a direction from said phonophoresis device directly into the spinal structures and/or the brain thereby essentially bypassing the blood brain barrier of the mammal, and thereby delivering said biologically active agent to the spinal structures and/or to the brain of said mammal
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3. Apparatus for enhanced and controlled delivery of a biologically active agent into the spinal structures and/or the brain of a mammal, particularly a human being that circumvents the blood brain barrier, comprising:
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an agent drug delivery device implantable via catheter to the epidural space of the mammal, a donor iontophoresis electrode also implantable to the epidural space of the mammal, a receptor iontophoresis electrode that is constructed and arranged to be positioned at a determined internal or external position of the mammal'"'"'s body but in complementary energy gradient positioning to the first electrode, means for providing a potential gradient so that delivery of the biologically active agent is accomplished in a direction from said first electrode means directly into the spinal structures and/or the brain thereby essentially bypassing the blood brain barrier of the mammal, and thereby delivering said biologically active agent to the spinal structures and/or to the brain of said mammal - View Dependent Claims (7, 8, 9, 10, 11, 12)
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4. Apparatus for enhanced and controlled delivery of a biologically active agent into the spinal structures and/or the brain of a mammal, particularly a human being that circumvents the blood brain barrier, comprising:
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an agent drug delivery device implantable via catheter to the epidural space of the mammal, a phonophoresis device implantable to the epidural space of the mammal, means for providing a potential gradient so that delivery of the biologically active agent is accomplished in a direction from said phonophoresis device directly into the spinal structures and/or the brain thereby essentially bypassing the s blood brain barrier of the mammal, and thereby delivering said biologically active agent to the spinal structures and/or to the brain of said mammal
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Specification