Method of fabricating a banded prolonged release active agent dosage form
First Claim
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1. A method of preparing an active agent dosage form for the prolonged delivery of the active agent, comprising:
- forming a blank from an active agent formulation matrix so that the blank has a groove circumscribing a portion of the external surface of the blank; and
depositing insoluble material in the groove.
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Abstract
The present invention is directed to an active agent dosage form and methods of its fabrication which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface one or more insoluble bands located in complementary grooves. The invention is also directed to articles of manufacture, methods and systems for fabricating the active agent dosage form.
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Citations
48 Claims
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1. A method of preparing an active agent dosage form for the prolonged delivery of the active agent, comprising:
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forming a blank from an active agent formulation matrix so that the blank has a groove circumscribing a portion of the external surface of the blank; and
depositing insoluble material in the groove. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for fabricating an active agent dosage form for the prolonged delivery of the active agent, comprising:
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providing a blank, the blank comprising an active agent formulation matrix having a groove circumscribing a portion of the external surface of the blank;
orienting the blank with respect to a forming means for forming a band in the groove; and
forming the band in the groove using the forming means. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An active agent dosage form for the prolonged delivery of an active agent formulation to a fluid environment of use, comprising:
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an active agent formulation matrix having a groove circumscribing a portion of the external surface thereof; and
an insoluble band disposed in said groove. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A blank for formation of a pharmaceutical dosage form for controlled delivery of an active agent, comprising:
an active agent formulation matrix having a groove circumscribing a portion of the external surface of said matrix. - View Dependent Claims (31, 32, 33, 34, 35)
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36. A system for fabricating an active agent dosage form for the prolonged delivery of the active agent, comprising:
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forming means for forming a band in a groove circumscribed on the external surface of a blank; and
orienting means for orienting, by way of the groove, the blank with respect to said forming means. - View Dependent Claims (37, 38, 39)
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40. A system for fabricating an active agent dosage form for the prolonged delivery of the active agent, comprising:
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a source of blanks, each of said blanks having a groove circumscribing a portion of the external surface of the blank; and
a banding station that forms a band of insoluble material in the groove. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48)
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Specification