Thermal sensor for fluid detection
First Claim
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1. A method of detecting the arrival of a biomolecular fluid in the local environment of a thermal sensor, the method comprising:
- (a) obtaining a first signal from the thermal sensor prior to arrival of the biomolecular fluid in the local environment;
(b) obtaining a second signal from the thermal sensor as the biomolecular fluid arrives in the local environment; and
(c) relating the first signal with the second signal to detect the arrival of the biomolecular fluid.
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Abstract
Embodiments of the invention provide a method for detecting the arrival of a fluid at or near a thermal sensor. A method includes obtaining a signal from the thermal sensor prior to arrival of the fluid, obtaining another signal during arrival of the fluid, and relating the two signals to indicate the arrival of the fluid. Devices for application of the method are also described.
100 Citations
32 Claims
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1. A method of detecting the arrival of a biomolecular fluid in the local environment of a thermal sensor, the method comprising:
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(a) obtaining a first signal from the thermal sensor prior to arrival of the biomolecular fluid in the local environment;
(b) obtaining a second signal from the thermal sensor as the biomolecular fluid arrives in the local environment; and
(c) relating the first signal with the second signal to detect the arrival of the biomolecular fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for determining the start time of a rate-based assay, comprising:
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(a) obtaining a first signal from a thermal sensor prior to arrival of the biomolecular fluid in the local environment;
(b) obtaining a second signal from the thermal sensor as the biomolecular fluid arrives in the local environment; and
(c) relating the first signal with the second signal to determine the start time of the rate-based assay. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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20. A method for detecting a dynamic change in the local environment of a detector element arising from a biomolecular fluid arriving at or near the local environment, comprising:
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a. applying a current to the detector element to raise the temperature of the local environment prior to contact with the biomolecular fluid, b. receiving a first signal from the detector element prior to arrival of the biomolecular fluid;
c. receiving a second signal from the detector element as the sample or fluid arrives at the local environment; and
d. relating the first signal with the second signal to detect a dynamic change in the local environment. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27)
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28. A method for determining the start time of a rate-based assay, comprising:
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a. Applying a current to a detector element having a local environment to raise the temperature of the local environment prior to the arrival of the biomolecular fluid at the local environment, b. obtaining a first signal from the detector element prior to arrival of the biomolecular fluid at the local environment;
c. obtaining a second signal from the detector element as the biomolecular fluid arrives at the local environment; and
d. relating the first signal with the second signal to determine the start time of the rate-based assay. - View Dependent Claims (29, 30, 31, 32)
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Specification